Ageing-Associated Genes in Model Organisms

Found 2205 results. Showing results 1 to 2205.

of 1
Entrez ID Symbol Name Organism Longevity influence Max average lifespan change More details
42186 14-3-3epsilon CG31196 gene product from transcript CG31196-RA Drosophila melanogaster Anti-Longevity 49% Increase 14-3-3epsilon
40575 5-HT2A 5-hydroxytryptamine (serotonin) receptor 2A Drosophila melanogaster Anti-Longevity 90% Increase 5-HT2A
852380 AAC3 ADP/ATP Carrier Saccharomyces cerevisiae Anti-Longevity 15% Increase AAC3
855581 AAH1 Adenine AminoHydrolase Saccharomyces cerevisiae Anti-Longevity Increase AAH1
181727 aak-2 AMP-Activated Kinase Caenorhabditis elegans Pro-Longevity Increase and Decrease aak-2
181492 aakb-1 AMP-Activated Kinase Beta subunit Caenorhabditis elegans Pro-Longevity Decrease aakb-1
176552 aakb-2 AMP-Activated Kinase Beta subunit Caenorhabditis elegans Pro-Longevity Decrease aakb-2
181736 aakg-2 Protein AAKG-2 Caenorhabditis elegans Pro-Longevity 47% Increase aakg-2
185079 aat-8 Amino Acid Transporter Caenorhabditis elegans Anti-Longevity 30% Increase aat-8
853755 AAT1 Aspartate AminoTransferase Saccharomyces cerevisiae Pro-Longevity 25% Increase AAT1
850714 AAT2 Aspartate AminoTransferase Saccharomyces cerevisiae Pro-Longevity 15% Increase AAT2
183860 abcx-1 ABC transporter, eXtended Caenorhabditis elegans Anti-Longevity 16% Increase abcx-1
850450 ABP1 Actin Binding Protein Saccharomyces cerevisiae Anti-Longevity Increase and Decrease ABP1
173404 abu-11 Activated in Blocked Unfolded protein response Caenorhabditis elegans Pro-Longevity 28% Increase abu-11
852925 ACB1 Acyl-CoA-Binding Saccharomyces cerevisiae Anti-Longevity Increase ACB1
177654 acdh-13 Acyl CoA DeHydrogenase Caenorhabditis elegans Anti-Longevity 57% Increase acdh-13
181706 ace-1 abnormal ACEtylcholinesterase Caenorhabditis elegans Anti-Longevity 8% Increase ace-1
852266 ACH1 Ach1p Saccharomyces cerevisiae Necessary For Fitness Decrease ACH1
185044 acl-11 ACyLtransferase-like Caenorhabditis elegans Anti-Longevity Increase acl-11
180780 acn-1 Inactive angiotensin-converting enzyme-related protein Caenorhabditis elegans Anti-Longevity 21% Increase acn-1
176121 aco-2 ACOnitase Caenorhabditis elegans Anti-Longevity 20% Increase aco-2
853230 ACO2 ACOnitase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease ACO2
178190 acs-20 Protein ACS-20 Caenorhabditis elegans Pro-Longevity 50% Decrease acs-20
176005 acs-4 fatty Acid CoA Synthetase family Caenorhabditis elegans Anti-Longevity 6% Increase acs-4
176785 acs-5 fatty Acid CoA Synthetase family Caenorhabditis elegans Anti-Longevity 52% Increase acs-5
174472 acs-7 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase acs-7
850846 ACS2 Acetyl CoA Synthetase Saccharomyces cerevisiae Pro-Longevity 70% Decrease ACS2
852059 ADA2 transcriptional ADAptor Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ADA2
224129 Adcy5 adenylate cyclase 5 Mus musculus Anti-Longevity 30% Increase Adcy5
855222 ADD37 Alpha1-proteinase inhibitor-Degradation Deficient Saccharomyces cerevisiae Necessary For Fitness Decrease ADD37
853629 ADD66 Alpha1-proteinase inhibitor-Degradation Deficient Saccharomyces cerevisiae Necessary For Fitness Decrease ADD66
851272 ADE1 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE1
855501 ADE12 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE12
855149 ADE17 ADEnine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease ADE17
854295 ADE2 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE2
853118 ADE3 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase and Decrease ADE3
855346 ADE4 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE4
852617 ADE5,7 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE5,7
852952 ADE6 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE6
854068 ADH1 Alcohol DeHydrogenase Saccharomyces cerevisiae Anti-Longevity 20% Increase ADH1
855349 ADH2 Alcohol DeHydrogenase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease ADH2
851812 ADK1 ADenylate Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease ADK1
172542 adr-1 Adenosine Deaminase that acts on RNA Caenorhabditis elegans Pro-Longevity 50% Decrease adr-1
176022 adr-2 Adenosine Deaminase that acts on RNA Caenorhabditis elegans Pro-Longevity 50% Decrease adr-2
851802 ADR1 Alcohol Dehydrogenase Regulator Saccharomyces cerevisiae Necessary For Fitness 35% Decrease ADR1
11549 Adra1a adrenergic receptor, alpha 1a Mus musculus Pro-Longevity 10% Increase Adra1a
11548 Adra1b adrenergic receptor, alpha 1b Mus musculus Anti-Longevity 11% Decrease Adra1b
855086 AEP1 ATPase ExPression Saccharomyces cerevisiae Anti-Longevity Increase and Decrease AEP1
856737 AFG3 ATPase Family Gene Saccharomyces cerevisiae Anti-Longevity 20% Increase AFG3
856132 AGC1 Aspartate-Glutamate Carrier Saccharomyces cerevisiae Anti-Longevity 30% Increase AGC1
174762 age-1 AGEing alteration AGE-1, abnormal DAuer Formation DAF-23 Caenorhabditis elegans Anti-Longevity 1000% Increase age-1
176695 agmo-1 Protein AGMO-1 Caenorhabditis elegans Pro-Longevity 30% Decrease agmo-1
850333 AGP1 high-Affinity Glutamine Permease Saccharomyces cerevisiae Anti-Longevity Increase AGP1
11607 Agtr1a Angiotensin II receptor, type 1a Mus musculus Anti-Longevity 26% Increase Agtr1a
172889 aha-1 Protein AHA-1 Caenorhabditis elegans Pro-Longevity 10% Decrease aha-1
38342 AhcyL1 Adenosylhomocysteinase like 1 Drosophila melanogaster Anti-Longevity 13% Increase AhcyL1
42043 AhcyL2 Adenosylhomocysteinase like 2 Drosophila melanogaster Anti-Longevity 21% Increase AhcyL2
853543 AIM24 Altered Inheritance rate of Mitochondria Saccharomyces cerevisiae Necessary For Fitness Decrease AIM24
855189 AIM36 Altered Inheritance rate of Mitochondria Saccharomyces cerevisiae Necessary For Fitness Decrease AIM36
181719 ain-1 ALG-1 INteracting protein Caenorhabditis elegans Pro-Longevity 10% Decrease ain-1
179898 aip-1 Arsenite Inducible Protein Caenorhabditis elegans Pro-Longevity 50% Decrease aip-1
852351 AKL1 Ark family Kinase-Like protein Saccharomyces cerevisiae Anti-Longevity 20% Increase AKL1
851857 AKR1 AnKyrin Repeat-containing protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease AKR1
179424 akt-1 AKT kinase family Caenorhabditis elegans Anti-Longevity Increase akt-1
41957 Akt1 CG4006 gene product from transcript CG4006-RA Drosophila melanogaster Pro-Longevity 11% Decrease Akt1
11651 Akt1 thymoma viral proto-oncogene 1 Mus musculus Anti-Longevity 12% Increase Akt1
11652 Akt2 thymoma viral proto-oncogene 2 Mus musculus Anti-Longevity 9% Increase Akt2
855205 ALD3 ALdehyde Dehydrogenase Saccharomyces cerevisiae Necessary For Fitness Decrease ALD3
854556 ALD4 ALdehyde Dehydrogenase Saccharomyces cerevisiae Anti-Longevity 50% Increase ALD4
856044 ALD6 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae Anti-Longevity Increase ALD6
173468 alg-2 Argonaute (plant)-Like Gene Caenorhabditis elegans Pro-Longevity 24% Decrease alg-2
855764 ALG12 Asparagine-Linked Glycosylation Saccharomyces cerevisiae Anti-Longevity 25% Increase ALG12
852196 ALG3 dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Saccharomyces cerevisiae Anti-Longevity 10% Increase ALG3
855874 ALG5 Asparagine-Linked Glycosylation Saccharomyces cerevisiae Anti-Longevity 50% Increase ALG5
854163 ALG6 dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Saccharomyces cerevisiae Anti-Longevity 15% Increase ALG6
173510 alh-6 ALdehyde deHydrogenase Caenorhabditis elegans Pro-Longevity Increase and Decrease alh-6
31957 alpha-Man-I Alpha Mannosidase I Drosophila melanogaster Anti-Longevity 39% Increase alpha-Man-I
851690 ALT2 ALanine Transaminase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ALT2
854973 AMD1 AMP Deaminase Saccharomyces cerevisiae Anti-Longevity Increase AMD1
852455 AMN1 Antagonist of Mitotic exit Network Saccharomyces cerevisiae Necessary For Fitness Decrease AMN1
186047 amt-2 AMmonium Transporter homolog Caenorhabditis elegans Anti-Longevity 20% Increase amt-2
856527 ANS1 Ans1p Saccharomyces cerevisiae Necessary For Fitness 25% Decrease ANS1
176773 ant-1.1 Adenine Nucleotide Translocator Caenorhabditis elegans Anti-Longevity 40% Increase ant-1.1
3640787 APC10 potential anaphase-promoting complex processivity factor Apc10 Saccharomyces cerevisiae Pro-Longevity Increase and Decrease APC10
854423 APC5 anaphase promoting complex subunit 5 Saccharomyces cerevisiae Unclear Decrease APC5
850792 APC9 anaphase promoting complex subunit 9 Saccharomyces cerevisiae Pro-Longevity Decrease APC9
852589 APE3 AminoPEptidase Saccharomyces cerevisiae Necessary For Fitness Decrease APE3
180783 apl-1 Beta-amyloid-like protein Caenorhabditis elegans Pro-Longevity 30% Increase apl-1
2540375 apl1 AP-2 adaptor complex beta subunit Apl1 Schizosaccharomyces pombe Anti-Longevity Increase apl1
853723 APL2 clathrin Adaptor Protein complex Large chain Saccharomyces cerevisiae Necessary For Fitness 25% Decrease APL2
2541162 apl3 AP-2 adaptor complex alpha subunit Alp3 Schizosaccharomyces pombe Anti-Longevity Increase apl3
855869 APM1 clathrin Adaptor Protein complex Medium chain Saccharomyces cerevisiae Necessary For Fitness 50% Decrease APM1
11816 Apoe Apolipoprotein E Mus musculus Pro-Longevity Decrease Apoe
178989 aps-1 Protein APS-1 Caenorhabditis elegans Anti-Longevity 8% Increase aps-1
171691 aps-3 daPtin, Small chain (clathrin associated complex) Caenorhabditis elegans Anti-Longevity 40% Increase aps-3
2541086 aps2 AP-2 adaptor complex sigma subunit Aps2 Schizosaccharomyces pombe Anti-Longevity Increase aps2
854986 APT1 Adenine PhosphoribosylTransferase Saccharomyces cerevisiae Anti-Longevity Increase APT1
181019 apy-1 APYrase Caenorhabditis elegans Pro-Longevity Decrease apy-1
855660 AQR1 Aqr1p Saccharomyces cerevisiae Unannotated AQR1
856404 ARD1 ARrest Defective Saccharomyces cerevisiae Necessary For Fitness Decrease ARD1
191609 arf-1.1 ADP-Ribosylation Factor related Caenorhabditis elegans Anti-Longevity 10% Increase arf-1.1
851335 ARF1 ADP-Ribosylation Factor Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ARF1
853374 ARG2 ARGinine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease ARG2
180080 argk-1 ARGinine Kinase Caenorhabditis elegans Pro-Longevity 25% Increase argk-1
228359 Arhgap1 Rho GTPase activating protein 1 Mus musculus Pro-Longevity Decrease Arhgap1
855711 ARK1 Actin Regulating Kinase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease ARK1
178405 arl-8 ARF-Like Caenorhabditis elegans Pro-Longevity Decrease arl-8
11865 Arntl aryl hydrocarbon receptor nuclear translocator-like Mus musculus Pro-Longevity Decrease Arntl
856173 ARO7 AROmatic amino acid requiring Saccharomyces cerevisiae Necessary For Fitness Decrease ARO7
856530 ARP1 Actin-Related Protein Saccharomyces cerevisiae Necessary For Fitness 40% Decrease ARP1
180446 arr-1 ARRestin family Caenorhabditis elegans Anti-Longevity 35% Increase arr-1
175247 arx-4 ARp2/3 compleX component Caenorhabditis elegans Pro-Longevity Decrease arx-4
175605 asb-1 Protein ASB-1 Caenorhabditis elegans Anti-Longevity 6% Increase asb-1
180718 asb-2 ATP Synthase B homolog Caenorhabditis elegans Anti-Longevity Increase asb-2
853327 ASF1 Anti-Silencing Function Saccharomyces cerevisiae Necessary For Fitness 74% Decrease ASF1
172673 asg-1 ATP Synthase G homolog Caenorhabditis elegans Anti-Longevity Increase asg-1
180956 asg-2 ATP synthase subunit Caenorhabditis elegans Anti-Longevity Increase asg-2
854676 ASG1 Activator of Stress Genes Saccharomyces cerevisiae Necessary For Fitness Decrease ASG1
174838 ash-2 ASH histone methyltransferase complex subunit (Drosophila absent, small or homeotic discs) Caenorhabditis elegans Anti-Longevity 30% Increase ash-2
176879 asm-3 Acid SphingoMyelinase Caenorhabditis elegans Anti-Longevity 50% Increase asm-3
174590 atad-3 ATPase family AAA domain-containing protein 3 Caenorhabditis elegans Anti-Longevity 29% Increase atad-3
181405 atf-6 ATF (cAMP-dependent transcription factor) family Caenorhabditis elegans Anti-Longevity 18% Increase atf-6
179922 atfs-1 Activating Transcription Factor associated with Stress Caenorhabditis elegans Anti-Longevity 26% Decrease atfs-1
179246 atg-18 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Unclear 20% Decrease atg-18
176921 atg-3 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Decrease atg-3
190777 atg-4.1 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Decrease atg-4.1
3565022 atg-4.2 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Decrease atg-4.2
171735 atg-5 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Decrease atg-5
178005 atg-7 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Unclear Increase atg-7
178561 atg-9 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Increase and Decrease atg-9
852695 ATG1 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 70% Decrease ATG1
39454 Atg1 Autophagy-specific gene 1 Drosophila melanogaster Pro-Longevity 25% Increase Atg1
850684 ATG10 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG10
852518 ATG12 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG12
856315 ATG13 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG13
852425 ATG14 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG14
850432 ATG15 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 40% Decrease ATG15
855194 ATG16 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG16
851142 ATG17 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 70% Decrease ATG17
850577 ATG18 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ATG18
38344 Atg2 Autophagy-specific gene 2 Drosophila melanogaster Pro-Longevity 28% Increase Atg2
855479 ATG2 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG2
2539317 atg20 sorting nexin Atg20 (predicted) Schizosaccharomyces pombe Anti-Longevity Increase atg20
856004 ATG21 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG21
855937 ATG29 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG29
855954 ATG5 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG5
11793 Atg5 autophagy related 5 Mus musculus Pro-Longevity 17% Increase Atg5
37141 Atg7 Autophagy-specific gene 7 Drosophila melanogaster Pro-Longevity Decrease Atg7
856576 ATG7 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 70% Decrease ATG7
852200 ATG8 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG8
32001 Atg8a Autophagy-related 8a Drosophila melanogaster Pro-Longevity Increase and Decrease Atg8a
851406 ATG9 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG9
856137 ATH1 Acid TreHalase Saccharomyces cerevisiae Necessary For Fitness Decrease ATH1
11920 Atm Ataxia telangiectasia mutated homolog (human) Mus musculus Pro-Longevity Decrease Atm
175716 atp-2 ATP synthase F1 subunit gamma Caenorhabditis elegans Anti-Longevity 43% Increase atp-2
172195 atp-3 ATP synthase subunit Caenorhabditis elegans Anti-Longevity 21% Increase atp-3
179025 atp-4 ATP synthase subunit Caenorhabditis elegans Anti-Longevity Increase atp-4
179541 atp-5 ATP synthase subunit Caenorhabditis elegans Anti-Longevity Increase atp-5
852177 ATP1 ATP synthase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease ATP1
854893 ATP18 ATP synthase Saccharomyces cerevisiae Necessary For Fitness 40% Decrease ATP18
853585 ATP2 ATP synthase F1 subunit gamma Saccharomyces cerevisiae Pro-Longevity 50% Decrease ATP2
852327 ATP3 ATP synthase Saccharomyces cerevisiae Anti-Longevity 50% Increase ATP3
856027 ATP4 ATP synthase Saccharomyces cerevisiae Necessary For Fitness 10% Decrease ATP4
36760 ATPCL ATP citrate lyase Drosophila melanogaster Anti-Longevity 32% Increase ATPCL
245000 Atr Ataxia telangiectasia and Rad3 related Mus musculus Pro-Longevity Decrease Atr
180049 atx-3 Protein ATX-3 Caenorhabditis elegans Anti-Longevity 50% Increase atx-3
40044 Aut1 Aut1 -CG6877 gene product from transcript CG6877-RA Drosophila melanogaster Pro-Longevity 28% Decrease Aut1
853457 AVT1 Amino acid Vacuolar Transport Saccharomyces cerevisiae Necessary For Fitness Decrease AVT1
179432 B0024.4 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase B0024.4
180344 B0250.5 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial Caenorhabditis elegans Anti-Longevity 10% Increase B0250.5
176217 B0303.2 Protein B0303.2 Caenorhabditis elegans Anti-Longevity 5% Increase B0303.2
174734 B0491.5 Protein B0491.5 Caenorhabditis elegans Anti-Longevity 60% Increase B0491.5
172954 B0511.6 Protein B0511.6 Caenorhabditis elegans Anti-Longevity 50% Increase B0511.6
182030 B0546.3 Protein B0546.3 Caenorhabditis elegans Anti-Longevity 27% Increase B0546.3
35900 babo baboon Drosophila melanogaster Anti-Longevity 16% Increase babo
176330 baf-1 Barrier to Autointegration Factor Caenorhabditis elegans Pro-Longevity 28% Decrease baf-1
43038 bam bag of marbles Drosophila melanogaster Pro-Longevity 50% Increase bam
852360 BAP2 Branched-chain Amino acid Permease Saccharomyces cerevisiae Necessary For Fitness Decrease BAP2
180982 bar-1 beta-catenin Caenorhabditis elegans Pro-Longevity 45% Decrease bar-1
853974 BAS1 BASal Saccharomyces cerevisiae Anti-Longevity 30% Increase BAS1
12028 Bax Bcl2-associated X protein Mus musculus Unannotated Increase Bax
181423 bcat-1 Branched-chain-amino-acid aminotransferase, cytosolic Caenorhabditis elegans Anti-Longevity 25% Increase bcat-1
33819 bchs blue cheese Drosophila melanogaster Pro-Longevity 45% Decrease bchs
853350 BCK1 Bypass of C Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease BCK1
851981 BCS1 ubiquinol-cytochrome c reductase (bc1) Synthesis Saccharomyces cerevisiae Necessary For Fitness Decrease BCS1
854778 BCY1 Bypass of CYclase mutations Saccharomyces cerevisiae Necessary For Fitness Decrease BCY1
177345 bec-1 BEClin (human autophagy) homolog Caenorhabditis elegans Pro-Longevity 40% Decrease bec-1
852499 BEM1 Bud EMergence Saccharomyces cerevisiae Necessary For Fitness 75% Decrease BEM1
172054 bet-1 BET-1 Caenorhabditis elegans Pro-Longevity Decrease bet-1
853551 BIR1 Baculoviral IAP Repeat-containing protein Saccharomyces cerevisiae Pro-Longevity Increase BIR1
172917 blmp-1 Blimp1 (B Lymphocyte-induced Maturation Protein-1) homolog Caenorhabditis elegans Pro-Longevity 20% Decrease blmp-1
39322 Bmcp Bmcp Drosophila melanogaster Anti-Longevity Increase Bmcp
856924 BMH1 Brain Modulosignalin Homologue Saccharomyces cerevisiae Unclear Increase and Decrease BMH1
851676 BMH2 Brain Modulosignalin Homologue Saccharomyces cerevisiae Pro-Longevity Increase BMH2
179948 bmk-1 Kinesin-like protein Caenorhabditis elegans Pro-Longevity 25% Increase bmk-1
853541 BNA2 Biosynthesis of Nicotinic Acid Saccharomyces cerevisiae Anti-Longevity Increase BNA2
850608 BNA6 Biosynthesis of Nicotinic Acid Saccharomyces cerevisiae Pro-Longevity Decrease BNA6
855450 BNI1 Bud Neck Involved Saccharomyces cerevisiae Necessary For Fitness 65% Decrease BNI1
856850 BOI2 Bem1 (One) Interacting protein Saccharomyces cerevisiae Anti-Longevity 25% Increase BOI2
850398 BPH1 Beige Protein Homolog Saccharomyces cerevisiae Necessary For Fitness Decrease BPH1
850645 BPT1 Bile Pigment Transporter Saccharomyces cerevisiae Anti-Longevity 20% Increase BPT1
181481 bra-1 BMP receptor Associated protein family Caenorhabditis elegans Pro-Longevity 25% Decrease bra-1
12189 Brca1 Breast cancer 1 Mus musculus Pro-Longevity Decrease Brca1
855787 BRE5 Bre5p Saccharomyces cerevisiae Anti-Longevity Increase and Decrease BRE5
851524 BSC1 Bypass of Stop Codon Saccharomyces cerevisiae Anti-Longevity 20% Increase BSC1
851868 BSC2 Bypass of Stop Codon Saccharomyces cerevisiae Anti-Longevity 20% Increase BSC2
44801 bsk basket Drosophila melanogaster Pro-Longevity 16% Decrease bsk
850519 BST1 Bst1p Saccharomyces cerevisiae Anti-Longevity 25% Increase BST1
175018 bub-3 yeast BUB homolog Caenorhabditis elegans Anti-Longevity 6% Increase bub-3
12236 Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) Mus musculus Pro-Longevity Increase and Decrease Bub1b
12237 Bub3 budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) Mus musculus Pro-Longevity 12% Decrease Bub3
851029 BUD6 BUD site selection Saccharomyces cerevisiae Unannotated BUD6
851459 BUG1 Binder of USO1 and GRH1 Saccharomyces cerevisiae Anti-Longevity Increase and Decrease BUG1
854929 BUL2 ubiquitin-ubiquitin ligase BUL2 Saccharomyces cerevisiae Unannotated 16% Increase BUL2
188726 bus-4 Protein BUS-4 Caenorhabditis elegans Pro-Longevity 10% Decrease bus-4
180821 bus-8 Bacterially Un-Swollen (M. nematophilum resistant) Caenorhabditis elegans Pro-Longevity 58% Decrease bus-8
173764 C01F1.1 Protein C01F1.1 Caenorhabditis elegans Pro-Longevity 28% Decrease C01F1.1
173427 C03H5.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase C03H5.3
182280 C06A5.1 Protein C06A5.1 Caenorhabditis elegans Pro-Longevity 39% Decrease C06A5.1
176368 C07A9.2 Protein C07A9.2 Caenorhabditis elegans Pro-Longevity 26% Decrease C07A9.2
182438 C09B7.2 transposase Caenorhabditis elegans Anti-Longevity Increase C09B7.2
181537 C11H1.3 Protein C11H1.3 Caenorhabditis elegans Pro-Longevity 10% Decrease C11H1.3
174637 C14A4.9 Protein C14A4.9 Caenorhabditis elegans Pro-Longevity 14% Decrease C14A4.9
174427 C18E9.10 Protein C18E9.10 Caenorhabditis elegans Anti-Longevity Increase C18E9.10
174428 C18E9.4 Protein C18E9.4 Caenorhabditis elegans Anti-Longevity 60% Increase C18E9.4
182926 C26B2.2 Protein C26B2.2 Caenorhabditis elegans Anti-Longevity Increase C26B2.2
180804 C26B9.3 Protein C26B9.3 Caenorhabditis elegans Pro-Longevity 12% Decrease C26B9.3
177708 C27B7.7 Protein C27B7.7 Caenorhabditis elegans Anti-Longevity Increase C27B7.7
175836 C28H8.11 Protein C28H8.11 Caenorhabditis elegans Anti-Longevity 15% Increase C28H8.11
175180 C29F9.1 Protein C29F9.1 Caenorhabditis elegans Pro-Longevity Decrease C29F9.1
175179 C29F9.2 Protein C29F9.2 Caenorhabditis elegans Pro-Longevity 12% Decrease C29F9.2
183168 C33F10.12 Protein C33F10.12 Caenorhabditis elegans Anti-Longevity Increase C33F10.12
3565046 C33H5.18 Protein C33H5.18 Caenorhabditis elegans Pro-Longevity 44% Decrease C33H5.18
172966 C34B2.6 Lon protease homolog, mitochondrial Caenorhabditis elegans Anti-Longevity 11% Increase C34B2.6
183228 C35A11.3 Protein C35A11.3 Caenorhabditis elegans Anti-Longevity Increase C35A11.3
178230 C36H8.1 Protein C36H8.1 Caenorhabditis elegans Anti-Longevity Increase C36H8.1
183399 C42C1.3 Protein C42C1.3 Caenorhabditis elegans Anti-Longevity 60% Increase C42C1.3
177367 C46G7.2 Protein C46G7.2 Caenorhabditis elegans Anti-Longevity 44% Increase C46G7.2
174789 C47D12.2 Protein C47D12.2 Caenorhabditis elegans Anti-Longevity 6% Increase C47D12.2
177858 C47E12.2 Protein C47E12.2 Caenorhabditis elegans Anti-Longevity 36% Increase C47E12.2
172321 C48E7.2 Protein C48E7.2 Caenorhabditis elegans Anti-Longevity 26% Increase C48E7.2
175898 C56G2.1 Protein C56G2.1 Caenorhabditis elegans Anti-Longevity 20% Increase C56G2.1
856772 CAJ1 Caj1p Saccharomyces cerevisiae Necessary For Fitness Decrease CAJ1
180769 calu-1 CALUmenin (calcium-binding protein) homolog Caenorhabditis elegans Pro-Longevity Decrease calu-1
856646 CAN1 arginine permease CAN1 Saccharomyces cerevisiae Anti-Longevity 30% Increase CAN1
32947 car carnation Drosophila melanogaster Pro-Longevity Increase car
2540626 car2 ornithine transaminase Car2 Schizosaccharomyces pombe Anti-Longevity Increase car2
12366 Casp2 caspase 2 Mus musculus Pro-Longevity Decrease Casp2
40048 Cat Catalase Drosophila melanogaster Pro-Longevity 33% Increase Cat
12359 Cat Catalase Mus musculus Pro-Longevity 21% Increase Cat
854292 CAT5 CATabolite repression Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CAT5
12389 Cav1 caveolin, caveolae protein 1 Mus musculus Pro-Longevity 50% Decrease Cav1
856347 CBP2 Cytochrome B mRNA Processing Saccharomyces cerevisiae Necessary For Fitness Decrease CBP2
853085 CBP4 Cytochrome B mRNA Processing Saccharomyces cerevisiae Necessary For Fitness Decrease CBP4
852417 CBP6 Cbp6p Saccharomyces cerevisiae Anti-Longevity 25% Increase CBP6
8582838 Cbr-daf-2 C. briggsae CBR-DAF-2 protein Caenorhabditis briggsae Anti-Longevity 40% Increase Cbr-daf-2
33081 Cbs Cystathionine beta-synthase Drosophila melanogaster Pro-Longevity 43% Increase Cbs
181215 cbs-1 Cystathionine Beta-Synthase Caenorhabditis elegans Pro-Longevity 50% Increase cbs-1
851491 CBS1 Cbs1p Saccharomyces cerevisiae Anti-Longevity 37% Increase CBS1
174713 cchl-1 Cytochrome C Heme-Lyase Caenorhabditis elegans Anti-Longevity 50% Increase cchl-1
172832 cco-1 Cytochrome C Oxidase Caenorhabditis elegans Anti-Longevity 80% Increase cco-1
176707 cco-2 Cytochrome C Oxidase Caenorhabditis elegans Anti-Longevity 60% Increase cco-2
178184 ccr-4 CCR (yeast CCR4/NOT complex component) homolog Caenorhabditis elegans Pro-Longevity 33% Decrease ccr-4
855054 CCS1 Ccs1p Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CCS1
174318 cct-1 T-complex protein 1 subunit alpha Caenorhabditis elegans Anti-Longevity 10% Increase cct-1
174330 cct-4 Chaperonin Containing TCP-1 Caenorhabditis elegans Anti-Longevity 28% Increase cct-4
175819 cct-6 Chaperonin Containing TCP-1 Caenorhabditis elegans Anti-Longevity 20% Increase cct-6
176928 cct-8 Chaperonin Containing TCP-1 Caenorhabditis elegans Anti-Longevity 16% Increase cct-8
117353 Cct1 CTP:phosphocholine cytidylyltransferase 1 Drosophila melanogaster Pro-Longevity 8% Increase Cct1
172353 cdc-25.1 Cell Division Cycle related Caenorhabditis elegans Anti-Longevity Increase cdc-25.1
176260 cdc-25.3 Cell Division Cycle related Caenorhabditis elegans Anti-Longevity 40% Increase cdc-25.3
174624 cdc-48.1 Protein CDC-48.1 Caenorhabditis elegans Anti-Longevity 50% Increase cdc-48.1
851306 CDC13 Cell Division Cycle Saccharomyces cerevisiae Pro-Longevity Decrease CDC13
218294 Cdc14b CDC14 cell division cycle 14B Mus musculus Pro-Longevity Cdc14b
851019 CDC25 Cdc25p Saccharomyces cerevisiae Anti-Longevity 50% Increase CDC25
850597 CDC26 anaphase promoting complex subunit CDC26 Saccharomyces cerevisiae Pro-Longevity Decrease CDC26
853244 CDC6 Cell Division Cycle Saccharomyces cerevisiae Anti-Longevity 20% Increase CDC6
852881 CDH1 CDC20 Homolog Saccharomyces cerevisiae Necessary For Fitness 45% Decrease CDH1
171784 cdk-7 Cyclin-Dependent Kinase family Caenorhabditis elegans Pro-Longevity Decrease cdk-7
36727 Cdk5 Cyclin-dependent kinase 5 Drosophila melanogaster Pro-Longevity 33% Decrease Cdk5
12572 Cdk7 cyclin-dependent kinase 7 Mus musculus Pro-Longevity Decrease Cdk7
12575 Cdkn1a Cyclin-dependent kinase inhibitor 1A Mus musculus Anti-Longevity Increase Cdkn1a
175559 cdtl-7 Protein CDTL-7 Caenorhabditis elegans Pro-Longevity 22% Decrease cdtl-7
12606 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus Unannotated Increase Cebpa
12608 Cebpb CCAAT/enhancer binding protein (C/EBP), beta Mus musculus Unannotated Increase Cebpb
174265 cec-3 Protein CEC-3 Caenorhabditis elegans Anti-Longevity Increase cec-3
178272 ced-3 CEll Death abnormality Caenorhabditis elegans Anti-Longevity 19% Increase ced-3
175811 ceh-10 ceh-10 Homeobox Caenorhabditis elegans Pro-Longevity 40% Decrease ceh-10
180671 ceh-18 Protein CEH-18 Caenorhabditis elegans Anti-Longevity Increase ceh-18
3565545 ceh-20 Protein CEH-20 Caenorhabditis elegans Pro-Longevity 12% Decrease ceh-20
176096 ceh-23 Protein CEH-23 Caenorhabditis elegans Pro-Longevity 25% Increase ceh-23
181530 ceh-37 Protein CEH-37 Caenorhabditis elegans Pro-Longevity 8% Decrease ceh-37
172814 cel-1 mRNA Capping Enzyme Like Caenorhabditis elegans Pro-Longevity 59% Decrease cel-1
182749 CELE_C17H1.7 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase CELE_C17H1.7
173963 CELE_C25H3.9 hypothetical protein Caenorhabditis elegans Anti-Longevity 30% Increase CELE_C25H3.9
183078 CELE_C31B8.4 hypothetical protein Caenorhabditis elegans Anti-Longevity 13% Increase CELE_C31B8.4
183126 CELE_C32H11.1 Protein C32H11.1 Caenorhabditis elegans Anti-Longevity Increase CELE_C32H11.1
183129 CELE_C32H11.5 Protein C32H11.5 Caenorhabditis elegans Anti-Longevity Increase CELE_C32H11.5
177786 CELE_C33A12.1 Protein C33A12.1 Caenorhabditis elegans Anti-Longevity 50% Increase CELE_C33A12.1
179499 CELE_D1054.14 Protein D1054.14 Caenorhabditis elegans Anti-Longevity 36% Increase CELE_D1054.14
183917 CELE_D1054.8 Dehydrogenase Caenorhabditis elegans Anti-Longevity Increase CELE_D1054.8
177262 CELE_E03H12.5 Protein E03H12.5 Caenorhabditis elegans Anti-Longevity Increase CELE_E03H12.5
179331 CELE_F11A3.2 hypothetical protein Caenorhabditis elegans Anti-Longevity 14% Increase CELE_F11A3.2
175926 CELE_F23F12.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase CELE_F23F12.3
176828 CELE_F29C4.2 Protein F29C4.2 Caenorhabditis elegans Anti-Longevity 100% Increase CELE_F29C4.2
176402 CELE_F40F12.7 Protein F40F12.7 Caenorhabditis elegans Pro-Longevity Decrease CELE_F40F12.7
185704 CELE_F43D2.1 Protein F43D2.1 Caenorhabditis elegans Pro-Longevity 20% Decrease CELE_F43D2.1
186068 CELE_F49F1.12 Protein F49F1.12 Caenorhabditis elegans Anti-Longevity Increase CELE_F49F1.12
173558 CELE_F52C6.2 Protein F52C6.2 Caenorhabditis elegans Pro-Longevity 19% Decrease CELE_F52C6.2
179849 CELE_F53F4.11 Protein F53F4.11 Caenorhabditis elegans Anti-Longevity 27% Increase CELE_F53F4.11
176945 CELE_F53H1.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 30% Increase CELE_F53H1.3
177772 CELE_F56D5.5 Protein F56D5.5 Caenorhabditis elegans Anti-Longevity 20% Increase CELE_F56D5.5
186593 CELE_F59B2.8 Protein F59B2.8 Caenorhabditis elegans Pro-Longevity Decrease CELE_F59B2.8
172933 CELE_F59C6.5 Protein F59C6.5 Caenorhabditis elegans Anti-Longevity 70% Increase CELE_F59C6.5
176838 CELE_R02D3.3 Protein R02D3.3 Caenorhabditis elegans Anti-Longevity 13% Increase CELE_R02D3.3
174683 CELE_R03D7.4 hypothetical protein Caenorhabditis elegans Anti-Longevity 13% Increase CELE_R03D7.4
187596 CELE_R05A10.5 Protein R05A10.5 Caenorhabditis elegans Anti-Longevity Increase CELE_R05A10.5
173140 CELE_T06G6.4 Protein T06G6.4 Caenorhabditis elegans Anti-Longevity Increase CELE_T06G6.4
173237 CELE_W09C5.8 Protein W09C5.8 Caenorhabditis elegans Anti-Longevity 100% Increase CELE_W09C5.8
180262 CELE_Y39B6A.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 50% Increase CELE_Y39B6A.3
189761 CELE_Y39F10C.1 Protein Y39F10C.1 Caenorhabditis elegans Anti-Longevity Increase CELE_Y39F10C.1
171792 CELE_Y39G10AR.8 Protein Y39G10AR.8 Caenorhabditis elegans Anti-Longevity 24% Increase CELE_Y39G10AR.8
189814 CELE_Y41C4A.11 hypothetical protein Caenorhabditis elegans Anti-Longevity 13% Increase CELE_Y41C4A.11
189875 CELE_Y43F8B.12 Protein Y43F8B.12 Caenorhabditis elegans Anti-Longevity Increase CELE_Y43F8B.12
174915 CELE_Y46G5A.20 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase CELE_Y46G5A.20
171919 CELE_Y47G6A.18 Protein Y47G6A.18 Caenorhabditis elegans Pro-Longevity Decrease CELE_Y47G6A.18
173061 CELE_Y47H9C.1 hypothetical protein Caenorhabditis elegans Anti-Longevity 10% Increase CELE_Y47H9C.1
173005 CELE_Y52B11A.9 hypothetical protein Caenorhabditis elegans Pro-Longevity 20% Decrease CELE_Y52B11A.9
190220 CELE_Y53F4B.23 Protein Y53F4B.23 Caenorhabditis elegans Anti-Longevity Increase CELE_Y53F4B.23
171874 CELE_Y54E10BR.4 Protein Y54E10BR.4 Caenorhabditis elegans Anti-Longevity 15% Increase CELE_Y54E10BR.4
177036 CELE_Y69A2AR.19 Protein Y69A2AR.19 Caenorhabditis elegans Anti-Longevity 19% Increase CELE_Y69A2AR.19
176648 CELE_Y75B8A.13 Protein Y75B8A.13 Caenorhabditis elegans Anti-Longevity Increase CELE_Y75B8A.13
190713 CELE_Y75B8A.33 Protein Y75B8A.33 Caenorhabditis elegans Anti-Longevity Increase CELE_Y75B8A.33
172616 cep-1 C. Elegans P-53-like protein Caenorhabditis elegans Anti-Longevity 33% Increase cep-1
38928 cert ceramide transfer protein Drosophila melanogaster Pro-Longevity Decrease cert
35751 CG11165 CG11165 Drosophila melanogaster Pro-Longevity 54% Increase CG11165
38100 CG13890 CG13890 Drosophila melanogaster Pro-Longevity 31% Increase CG13890
32955 CG14207 CG14207-PA Drosophila melanogaster Pro-Longevity 5% Increase CG14207
43369 CG17856 CG17856 gene product from transcript CG17856-RA Drosophila melanogaster Anti-Longevity 18% Increase CG17856
59170 CG18809 CG18809 gene product from transcript CG18809-RA Drosophila melanogaster Anti-Longevity 19% Increase CG18809
33231 CG2789 CG2789 Drosophila melanogaster Anti-Longevity 27% Increase CG2789
37996 CG3776 Juvenile hormone esterase binding protein 29 (DmP29) Drosophila melanogaster Anti-Longevity 43% Decrease CG3776
37996 CG3776 Juvenile hormone esterase binding protein 29 (DmP29) Drosophila melanogaster Pro-Longevity 39% Decrease CG3776
7354421 CG42358 CG42358 Drosophila melanogaster Anti-Longevity Increase and Decrease CG42358
39761 CG5389 CG5389 gene product from transcript CG5389-RA Drosophila melanogaster Anti-Longevity 11% Increase CG5389
32565 CG9172 CG9172 gene product from transcript CG9172-RA Drosophila melanogaster Anti-Longevity 46% Increase CG9172
32328 CG9940 CG9940 Drosophila melanogaster Pro-Longevity Increase CG9940
181790 cgt-2 Ceramide glucosyltransferase 2 Caenorhabditis elegans Anti-Longevity 40% Increase cgt-2
176434 chc-1 Clathrin Heavy Chain Caenorhabditis elegans Pro-Longevity 40% Decrease chc-1
856911 CHD1 Chromatin organization modifier, Helicase, and DNA-binding domains Saccharomyces cerevisiae Anti-Longevity Increase and Decrease CHD1
179666 che-11 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 40% Increase che-11
186607 che-13 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 40% Increase che-13
180401 che-2 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 50% Increase che-2
172593 che-3 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 100% Increase che-3
50883 Chek2 CHK2 checkpoint homolog (S. pombe) Mus musculus Pro-Longevity Decrease Chek2
42066 cher cheerio Drosophila melanogaster Pro-Longevity 9% Increase cher
64880 chico Insulin receptor substrate-1 Drosophila melanogaster Anti-Longevity 48% Increase chico
3565921 chk-1 CHeckpoint Kinase Caenorhabditis elegans Anti-Longevity 25% Increase chk-1
856099 CHL1 Chl1p Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CHL1
43928 chm chameau Drosophila melanogaster Anti-Longevity 24% Increase chm
172303 chn-1 Protein CHN-1 Caenorhabditis elegans Anti-Longevity 7% Increase chn-1
175707 cid-1 Caffeine Induced Death (S. pombe Cid) homolog Caenorhabditis elegans Anti-Longevity Increase cid-1
67006 Cisd2 CDGSH iron sulfur domain 2 Mus musculus Pro-Longevity Increase and Decrease Cisd2
176126 cit-1.2 CyclIn T Caenorhabditis elegans Pro-Longevity Decrease cit-1.2
855732 CIT1 CITrate synthase Saccharomyces cerevisiae Necessary For Fitness Decrease CIT1
850361 CIT2 CITrate synthase Saccharomyces cerevisiae Necessary For Fitness Decrease CIT2
854227 CKA2 Casein Kinase Alpha' subunit Saccharomyces cerevisiae Anti-Longevity Increase CKA2
176546 cku-70 Caenorhabditis KU Caenorhabditis elegans Anti-Longevity Increase cku-70
855418 CLA4 CLn Activity dependant Saccharomyces cerevisiae Necessary For Fitness 60% Decrease CLA4
853002 CLB1 CycLin B Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CLB1
856236 CLB2 CycLin B Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CLB2
178238 clec-186 C-type LECtin Caenorhabditis elegans Anti-Longevity Increase clec-186
184216 clec-227 C-type LECtin Caenorhabditis elegans Anti-Longevity Increase clec-227
852657 CLG1 Cyclin-Like Gene Saccharomyces cerevisiae Necessary For Fitness Decrease CLG1
175729 clk-1 Coenzyme Q7 homolog Caenorhabditis elegans Anti-Longevity Increase and Decrease clk-1
176065 clk-2 CLocK (biological timing) abnormality Caenorhabditis elegans Unannotated 25% Increase clk-2
851191 CLN3 Cln3p Saccharomyces cerevisiae Anti-Longevity Decrease CLN3
12753 Clock Circadian locomotor output cycles kaput Mus musculus Pro-Longevity 15% Decrease Clock
31647 cm carmine Drosophila melanogaster Pro-Longevity Decrease cm
179572 cnb-1 CalciNeurin B Caenorhabditis elegans Anti-Longevity 30% Increase cnb-1
855287 COA6 Cytochrome Oxidase Assembly Saccharomyces cerevisiae Necessary For Fitness Decrease COA6
259335 col-93 COLlagen Caenorhabditis elegans Anti-Longevity Increase col-93
12842 Col1a1 collagen, type I, alpha 1 Mus musculus Pro-Longevity Decrease Col1a1
852288 COQ1 COenzyme Q Saccharomyces cerevisiae Necessary For Fitness Decrease COQ1
854154 COQ10 COenzyme Q Saccharomyces cerevisiae Necessary For Fitness Decrease COQ10
40988 Coq2 Coenzyme Q biosynthesis protein 2 Drosophila melanogaster Anti-Longevity 31% Increase Coq2
854057 COQ3 COenzyme Q Saccharomyces cerevisiae Necessary For Fitness Decrease COQ3
854930 COQ5 COenzyme Q Saccharomyces cerevisiae Necessary For Fitness Decrease COQ5
12850 Coq7 demethyl-Q 7 Mus musculus Anti-Longevity 30% Increase Coq7
852235 COR1 CORe protein of QH2 cytochrome c reductase Saccharomyces cerevisiae Necessary For Fitness Decrease COR1
802462 cox1 Cytochrome c oxidase I Podospora anserina Unannotated Increase cox1
802462 cox1 cytochrome c oxidase subunit 1 Podospora anserina Unannotated Increase cox1
855971 COX11 Cytochrome c OXidase Saccharomyces cerevisiae Necessary For Fitness Decrease COX11
856516 COX23 Cytochrome OXidase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease COX23
171986 cpn-3 CalPoNin Caenorhabditis elegans Anti-Longevity 10% Increase cpn-3
3565393 cpna-3 Protein CPNA-3 Caenorhabditis elegans Anti-Longevity Increase cpna-3
853267 CPS1 CarboxyPeptidase yscS Saccharomyces cerevisiae Necessary For Fitness Decrease CPS1
854267 CRC1 CaRnitine Carrier Saccharomyces cerevisiae Anti-Longevity 25% Increase CRC1
174634 crn-5 Cell-death-Related Nuclease Caenorhabditis elegans Anti-Longevity 41% Increase crn-5
34592 crol crooked legs Drosophila melanogaster Anti-Longevity 27% Increase crol
259368 crtc-1 hypothetical protein Caenorhabditis elegans Anti-Longevity 53% Increase crtc-1
852324 CSG2 Calcium Sensitive Growth Saccharomyces cerevisiae Necessary For Fitness 40% Decrease CSG2
101830758 Csnk1e casein kinase 1, epsilon Mesocricetus auratus Unannotated Increase Csnk1e
177391 csp-2 CaSPase Caenorhabditis elegans Anti-Longevity Increase csp-2
856142 CSR2 Csr2p Saccharomyces cerevisiae Anti-Longevity Increase CSR2
180708 cst-1 Caenorhabditis STE20-like kinase Caenorhabditis elegans Pro-Longevity Increase and Decrease cst-1
852330 CST26 Chromosome STability Saccharomyces cerevisiae Anti-Longevity 40% Increase CST26
851843 CTA1 CaTalase A Saccharomyces cerevisiae Anti-Longevity Increase and Decrease CTA1
180853 ctbp-1 C-terminal-binding protein 1 Caenorhabditis elegans Anti-Longevity 20% Increase ctbp-1
13019 Ctf1 cardiotrophin 1 Mus musculus Anti-Longevity 18% Increase Ctf1
856254 CTF4 Chromosome Transmission Fidelity Saccharomyces cerevisiae Pro-Longevity Decrease CTF4
180079 cth-1 CystaTHionine gamma lyase Caenorhabditis elegans Pro-Longevity 15% Decrease cth-1
174155 cth-2 Putative cystathionine gamma-lyase 2 Caenorhabditis elegans Pro-Longevity 25% Decrease cth-2
851729 CTH1 Cysteine-Three-Histidine Saccharomyces cerevisiae Anti-Longevity 20% Increase CTH1
853718 CTK1 Carboxy-Terminal domain Kinase Saccharomyces cerevisiae Necessary For Fitness 80% Decrease CTK1
856241 CTR1 Copper TRansport Saccharomyces cerevisiae Pro-Longevity Increase and Decrease CTR1
852979 CTT1 Cytosolic catalase T Saccharomyces cerevisiae Unannotated Increase CTT1
176770 cua-1 CU (copper) ATPase Caenorhabditis elegans Pro-Longevity 12% Decrease cua-1
176466 cul-1 CULlin Caenorhabditis elegans Pro-Longevity Decrease cul-1
176104 cup-4 Coelomocyte UPtake defective Caenorhabditis elegans Pro-Longevity 10% Decrease cup-4
855926 CUP9 Cup9p Saccharomyces cerevisiae Necessary For Fitness 30% Decrease CUP9
176895 cutl-28 CUTiclin-Like Caenorhabditis elegans Anti-Longevity 28% Increase cutl-28
850376 CWH43 Calcofluor White Hypersensitive Saccharomyces cerevisiae Necessary For Fitness Decrease CWH43
178894 cwp-4 Coexpressed With Polycystins Caenorhabditis elegans Anti-Longevity Increase cwp-4
855612 CYB5 Cyb5p Saccharomyces cerevisiae Unannotated CYB5
172582 cyc-1 Cytochrome c1 Caenorhabditis elegans Anti-Longevity 87% Increase cyc-1
177243 cyc-2.1 CYtochrome C Caenorhabditis elegans Anti-Longevity 80% Increase cyc-2.1
853507 CYC1 CYtochrome C Saccharomyces cerevisiae Necessary For Fitness 60% Decrease CYC1
854202 CYC2 CYtochrome C Saccharomyces cerevisiae Necessary For Fitness Decrease CYC2
851192 CYC3 CYtochrome C Saccharomyces cerevisiae Necessary For Fitness 20% Decrease CYC3
175853 cyk-3 cyk-3 Caenorhabditis elegans Anti-Longevity 15% Increase cyk-3
181462 cyp-13B1 CYtochrome P450 family Caenorhabditis elegans Anti-Longevity 20% Increase cyp-13B1
185653 cyp-33E2 CYtochrome P450 family Caenorhabditis elegans Anti-Longevity 18% Increase cyp-33E2
180236 cyp-42A1 CYtochrome P450 family Caenorhabditis elegans Pro-Longevity 39% Decrease cyp-42A1
853452 CYR1 Adenylate cyclase Saccharomyces cerevisiae Anti-Longevity 90% Increase CYR1
853059 CYS4 CYStathionine beta-synthase Saccharomyces cerevisiae Anti-Longevity 50% Increase CYS4
854231 CYT1 ubiquinol--cytochrome-c reductase catalytic subunit CYT1 Saccharomyces cerevisiae Anti-Longevity Increase and Decrease CYT1
853775 CYT2 cytochrome c1 heme lyase CYT2 Saccharomyces cerevisiae Necessary For Fitness 25% Decrease CYT2
173425 D1069.3 D1069.3b Caenorhabditis elegans Pro-Longevity Decrease D1069.3
172510 D2030.1 Alpha-1,2-mannosidase I Caenorhabditis elegans Anti-Longevity 9% Increase D2030.1
172513 D2030.4 Protein D2030.4 Caenorhabditis elegans Anti-Longevity 40% Increase D2030.4
174387 D2085.3 Protein D2085.3 Caenorhabditis elegans Anti-Longevity Increase D2085.3
176829 daf-1 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 46% Increase daf-1
184883 daf-10 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 60% Increase daf-10
181263 daf-12 Abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity Increase daf-12
177908 daf-14 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 44% Increase daf-14
177770 daf-15 Abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity Increase daf-15
172981 daf-16 Abnormal DAuer Formation DAF-16, fork head-related transcription factor (daf-16) Caenorhabditis elegans Pro-Longevity 45% Decrease daf-16
176869 daf-18 Abnormal DAuer Formation Caenorhabditis elegans Pro-Longevity Increase and Decrease daf-18
174577 daf-19 Abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 50% Increase daf-19
175410 daf-2 abnormal DAuer Formation DAF-2, fork head-related transcription factor (daf-2) Caenorhabditis elegans Anti-Longevity 200% Increase daf-2
191014 daf-28 Abnormal DAuer Formation Caenorhabditis elegans Pro-Longevity 15% Increase daf-28
180431 daf-3 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 16% Decrease daf-3
175781 daf-4 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 120% Increase daf-4
175054 daf-5 abnormal DAuer Formation Caenorhabditis elegans Pro-Longevity 20% Decrease daf-5
181584 daf-6 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 50% Increase daf-6
175237 daf-7 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 50% Increase daf-7
187612 daf-8 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 31% Increase daf-8
180889 daf-9 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 74% Increase daf-9
3565075 dagl-2 DiAcylGlycerol Lipase homolog Caenorhabditis elegans Pro-Longevity 13% Increase dagl-2
856423 DAP2 YHR028C Saccharomyces cerevisiae Necessary For Fitness 19% Decrease DAP2
851583 DAS2 Dst1-delta 6-Azauracil Sensitivity Saccharomyces cerevisiae Anti-Longevity 25% Increase DAS2
33474 daw dawdle Drosophila melanogaster Anti-Longevity 35% Increase daw
852984 DBF2 DumbBell Forming Saccharomyces cerevisiae Necessary For Fitness 60% Decrease DBF2
855984 DBP1 Dead Box Protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease DBP1
852802 DBP3 Dead Box Protein Saccharomyces cerevisiae Anti-Longevity 35% Increase DBP3
850819 DCN1 Defective in Cullin Neddylation Saccharomyces cerevisiae Necessary For Fitness Decrease DCN1
176138 dcr-1 Endoribonuclease dcr-1 Caenorhabditis elegans Pro-Longevity Decrease dcr-1
189237 dct-11 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Pro-Longevity 10% Decrease dct-11
190351 dct-12 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Anti-Longevity 14% Increase dct-12
178476 dct-13 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Anti-Longevity 23% Increase dct-13
189684 dct-14 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Anti-Longevity 19% Increase dct-14
189289 dct-15 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Anti-Longevity 10% Increase dct-15
174934 dct-18 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Pro-Longevity 8% Decrease dct-18
853820 DCW1 Defective Cell Wall Saccharomyces cerevisiae Anti-Longevity Increase DCW1
173954 ddl-1 Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) Caenorhabditis elegans Anti-Longevity 24% Increase ddl-1
190025 ddl-2 Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) Caenorhabditis elegans Anti-Longevity 24% Increase ddl-2
175087 ddl-3 Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) Caenorhabditis elegans Anti-Longevity Increase ddl-3
852500 DER1 Der1p Saccharomyces cerevisiae Anti-Longevity 16% Increase DER1
179574 des-2 DEgeneration Suppressor Caenorhabditis elegans Anti-Longevity 60% Increase des-2
13350 Dgat1 diacylglycerol O-acyltransferase 1 Mus musculus Anti-Longevity 23% Increase Dgat1
174068 dgk-5 Putative diacylglycerol kinase K06A1.6 Caenorhabditis elegans Anti-Longevity 11% Increase dgk-5
853738 DGR2 2-Deoxy-Glucose Resistant 2 Saccharomyces cerevisiae Necessary For Fitness Decrease DGR2
179741 dhs-21 DeHydrogenases, Short chain Caenorhabditis elegans Pro-Longevity Decrease dhs-21
177676 dic-1 human DICE1 (Deleted In Cancer) homolog Caenorhabditis elegans Anti-Longevity 22% Increase dic-1
853906 DID2 Doa4-Independent Degradation Saccharomyces cerevisiae Necessary For Fitness Decrease DID2
853142 DIE2 Derepression of ITR1 Expression Saccharomyces cerevisiae Anti-Longevity 50% Increase DIE2
851157 DIF1 Damage-regulated Import Facilitator Saccharomyces cerevisiae Necessary For Fitness 20% Decrease DIF1
174782 din-1 DAF-12 Interacting Protein Caenorhabditis elegans Pro-Longevity Decrease din-1
177875 dis-3 DIS3 (yeast disjunction abnormal) exonuclease homolog Caenorhabditis elegans Pro-Longevity 11% Decrease dis-3
36543 DJ-1alpha DJ-1alpha Drosophila melanogaster Pro-Longevity Decrease DJ-1alpha
43652 dj-1beta dj-1beta Drosophila melanogaster Pro-Longevity Decrease dj-1beta
180121 dkf-2 D Kinase Family Caenorhabditis elegans Anti-Longevity 40% Increase dkf-2
179945 dlat-1 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Caenorhabditis elegans Anti-Longevity 10% Increase dlat-1
178387 dld-1 Protein DLD-1 Caenorhabditis elegans Anti-Longevity 61% Increase dld-1
173128 dlk-1 DAP (Death Associated Protein kinase) Like Kinase Caenorhabditis elegans Pro-Longevity Decrease dlk-1
33906 DLP Daxx-like protein Drosophila melanogaster Pro-Longevity 20% Decrease DLP
853381 DLS1 Dls1p Saccharomyces cerevisiae Anti-Longevity 20% Increase DLS1
31310 dm diminutive Drosophila melanogaster Anti-Longevity 47% Decrease dm
13405 Dmd Dystrophin, muscular dystrophy Mus musculus Pro-Longevity 18% Decrease Dmd
856569 DNA2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent Saccharomyces cerevisiae Pro-Longevity Decrease DNA2
3772064 DNApol-gamma35 DNA polymerase Gamma Drosophila melanogaster Anti-Longevity 52% Decrease DNApol-gamma35
31309 dnc dunce Drosophila melanogaster Anti-Longevity Increase dnc
856913 DNF1 Drs2 Neo1 Family Saccharomyces cerevisiae Anti-Longevity 50% Increase DNF1
172231 dnj-21 Mitochondrial import inner membrane translocase subunit TIM14 Caenorhabditis elegans Pro-Longevity 10% Decrease dnj-21
850686 DNM1 Dnm1p Saccharomyces cerevisiae Anti-Longevity Increase DNM1
851641 DOA4 Degradation Of Alpha Saccharomyces cerevisiae Necessary For Fitness 50% Decrease DOA4
187266 dod-17 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-17
183813 dod-18 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-18
178564 dod-19 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-19
182037 dod-20 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-20
183134 dod-21 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-21
178247 dod-22 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-22
186056 dod-23 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-23
178245 dod-24 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-24
31118 dor deep orange Drosophila melanogaster Pro-Longevity Decrease dor
171797 dot-1.1 DOT1 histone methyltransferase Caenorhabditis elegans Anti-Longevity 15% Increase dot-1.1
852050 DOT1 histone methyltransferase DOT1 Saccharomyces cerevisiae Necessary For Fitness 24% Decrease DOT1
851699 DPB4 Dpb4p Saccharomyces cerevisiae Necessary For Fitness 15% Decrease DPB4
854703 DPH1 DiPHthamide biosynthesis Saccharomyces cerevisiae Necessary For Fitness Decrease DPH1
33432 dpp decapentaplegic Drosophila melanogaster Pro-Longevity 29% Decrease dpp
175492 dpy-27 Protein DPY-27 Caenorhabditis elegans Pro-Longevity 24% Decrease dpy-27
3565236 drl-1 Dietary Restriction Like Caenorhabditis elegans Anti-Longevity 60% Increase drl-1
33445 Drp1 Dynamin related protein 1 Drosophila melanogaster Pro-Longevity 21% Increase Drp1
174994 drr-1 Protein DRR-1 Caenorhabditis elegans Anti-Longevity Increase drr-1
259546 drr-2 Protein DRR-2 Caenorhabditis elegans Anti-Longevity Increase drr-2
855331 DSS1 Deletion of SUV3 Supressor Saccharomyces cerevisiae Anti-Longevity Increase and Decrease DSS1
850605 DUG1 Deficient in Utilization of Glutathione Saccharomyces cerevisiae Anti-Longevity Increase DUG1
852584 DUG2 Deficient in Utilization of Glutathione Saccharomyces cerevisiae Necessary For Fitness Decrease DUG2
851457 DUN1 DNA-damage UNinducible Saccharomyces cerevisiae Necessary For Fitness 25% Decrease DUN1
180398 dve-1 DVE (Defective proVEntriculus in Drosophila) homolog Caenorhabditis elegans Pro-Longevity 53% Decrease dve-1
852034 DYN2 DYNein Saccharomyces cerevisiae Necessary For Fitness Decrease DYN2
42327 Dys Dystrophin Drosophila melanogaster Pro-Longevity Decrease Dys
39203 E(z) Enhancer of zeste Drosophila melanogaster Anti-Longevity 76% Increase E(z)
180175 E01B7.1 Protein E01B7.1 Caenorhabditis elegans Pro-Longevity Decrease E01B7.1
177242 E04A4.5 Probable mitochondrial import inner membrane translocase subunit Tim17 Caenorhabditis elegans Pro-Longevity 8% Decrease E04A4.5
3564920 eak-7 hypothetical protein Caenorhabditis elegans Unclear 30% Increase eak-7
eat-1 EATing: abnormal pharyngeal pumping Caenorhabditis elegans Anti-Longevity 30% Increase eat-1
13183021 eat-18 EATing: abnormal pharyngeal pumping Caenorhabditis elegans Anti-Longevity 60% Increase eat-18
24105308 eat-18 hypothetical protein Caenorhabditis elegans Anti-Longevity 14% Increase eat-18
175072 eat-2 EATing: abnormal pharyngeal pumping EAT-2 Caenorhabditis elegans Anti-Longevity Increase eat-2
174476 eat-3 EATing: abnormal pharyngeal pumping Caenorhabditis elegans Anti-Longevity 10% Increase eat-3
179796 eat-6 EATing: abnormal pharyngeal pumping Caenorhabditis elegans Anti-Longevity 40% Increase eat-6
852370 ECM33 ExtraCellular Mutant Saccharomyces cerevisiae Necessary For Fitness Decrease ECM33
856342 ECM34 ExtraCellular Mutant Saccharomyces cerevisiae Necessary For Fitness Decrease ECM34
35540 EcR Ecdysone receptor Drosophila melanogaster Anti-Longevity 50% Increase EcR
31154 Edem1 CG3810 gene product from transcript CG3810-RC Drosophila melanogaster Anti-Longevity 30% Increase Edem1
175975 eef-1A.1 Elongation factor 1-alpha Caenorhabditis elegans Anti-Longevity 18% Increase eef-1A.1
172743 eef-2 Elongation Factor Caenorhabditis elegans Unclear Increase and Decrease eef-2
66143 Eef1e1 Eukaryotic translation elongation factor 1 epsilon 1 Mus musculus Anti-Longevity 50% Decrease Eef1e1
36271 Ef1alpha48D Elongation factor 148D Drosophila melanogaster Pro-Longevity 41% Increase Ef1alpha48D
216616 Efemp1 Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 Mus musculus Pro-Longevity 20% Decrease Efemp1
854301 EFT1 Elongation Factor Two Saccharomyces cerevisiae Necessary For Fitness 30% Decrease EFT1
851993 EFT2 Elongation Factor Two Saccharomyces cerevisiae Necessary For Fitness Decrease EFT2
856070 EGD1 Enhancer of Gal4 DNA binding Saccharomyces cerevisiae Necessary For Fitness Decrease EGD1
856600 EGD2 Enhancer of Gal4 DNA binding Saccharomyces cerevisiae Necessary For Fitness 20% Decrease EGD2
179707 egl-10 EGg Laying defective Caenorhabditis elegans Anti-Longevity Increase egl-10
176992 egl-18 Erythroid-Like Transcription factor family Caenorhabditis elegans Anti-Longevity Increase egl-18
174121 egl-27 Protein EGL-27 Caenorhabditis elegans Pro-Longevity 18% Increase egl-27
179412 egl-3 EGg Laying defective Caenorhabditis elegans Anti-Longevity 65% Increase egl-3
171751 egl-30 EGg Laying defective Caenorhabditis elegans Anti-Longevity 38% Increase egl-30
176094 egl-45 EGg Laying defective Caenorhabditis elegans Anti-Longevity 52% Increase egl-45
178537 egl-8 EGg Laying defective Caenorhabditis elegans Anti-Longevity 83% Increase egl-8
179461 egl-9 EGg Laying defective Caenorhabditis elegans Anti-Longevity 20% Increase egl-9
36242 Egm enigma Drosophila melanogaster Anti-Longevity Increase Egm
266853 eif-1 Protein EIF-1 Caenorhabditis elegans Anti-Longevity 25% Increase eif-1
175138 eif-3.B Eukaryotic Initiation Factor Caenorhabditis elegans Anti-Longevity 51% Increase eif-3.B
174478 eif-3.F Eukaryotic Initiation Factor Caenorhabditis elegans Anti-Longevity 32% Increase eif-3.F
179779 eif-3.K Eukaryotic translation initiation factor 3 subunit K Caenorhabditis elegans Anti-Longevity 40% Increase eif-3.K
208691 Eif5a2 eukaryotic translation initiation factor 5A2 Mus musculus Anti-Longevity Decrease Eif5a2
39675 Eip71CD Ecdysone-induced protein 28/29kD Drosophila melanogaster Pro-Longevity 70% Increase Eip71CD
31000 elav embryonic lethal abnormal vision Drosophila melanogaster Pro-Longevity 66% Decrease elav
190775 elc-1 ELongin C Caenorhabditis elegans Anti-Longevity 12% Increase elc-1
177787 elo-1 fatty acid ELOngation Caenorhabditis elegans Anti-Longevity 11% Increase elo-1
178532 elo-2 fatty acid ELOngation Caenorhabditis elegans Anti-Longevity 9% Increase elo-2
177320 elo-5 fatty acid ELOngation Caenorhabditis elegans Pro-Longevity 45% Decrease elo-5
856019 ELP3 ELongator Protein Saccharomyces cerevisiae Anti-Longevity Increase ELP3
856002 ELP4 ELongator Protein Saccharomyces cerevisiae Anti-Longevity 30% Increase ELP4
176993 elt-6 Erythroid-Like Transcription factor family Caenorhabditis elegans Anti-Longevity 34% Increase elt-6
174314 emb-27 Protein EMB-27 Caenorhabditis elegans Anti-Longevity 10% Increase emb-27
852125 EMI1 Early Meiotic Induction Saccharomyces cerevisiae Anti-Longevity Increase and Decrease EMI1
184599 ent-5 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase ent-5
852962 ENV11 late ENdosome and Vacuole interface function Saccharomyces cerevisiae Necessary For Fitness 60% Decrease ENV11
855644 EOS1 Eos1p Saccharomyces cerevisiae Anti-Longevity 24% Increase EOS1
176679 epc-1 Enhancer of PolyComb-like Caenorhabditis elegans Anti-Longevity 20% Increase epc-1
13860 Eps8 Epidermal growth factor receptor pathway substrate 8 Mus musculus Anti-Longevity 37% Increase Eps8
13870 Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 Mus musculus Pro-Longevity 83% Decrease Ercc1
13871 Ercc2 Excision repair cross-complementing rodent repair deficiency, complementation group 2 Mus musculus Pro-Longevity Decrease Ercc2
50505 Ercc4 Excision repair cross-complementing rodent repair deficiency, complementation group 4 Mus musculus Pro-Longevity Decrease Ercc4
855441 ERG24 ERGosterol biosynthesis Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ERG24
855029 ERG5 ERGosterol biosynthesis Saccharomyces cerevisiae Necessary For Fitness 35% Decrease ERG5
855003 ERG6 ERGosterol biosynthesis Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ERG6
178602 ergo-1 Endogenous-RNAi deficient arGOnaute Caenorhabditis elegans Anti-Longevity 19% Increase ergo-1
176868 eri-1 Enhanced RNAI (RNA interference) Caenorhabditis elegans Pro-Longevity 43% Decrease eri-1
172174 erm-1 Ezrin/Radixin/Moesin Caenorhabditis elegans Anti-Longevity 15% Increase erm-1
173325 ero-1 Endoplasmic Reticulum Oxidase Caenorhabditis elegans Anti-Longevity 32% Increase ero-1
854909 ERO1 ER oxidoreductin Saccharomyces cerevisiae Anti-Longevity 28% Increase ERO1
856152 ERV2 Essential for Respiration and Viability Saccharomyces cerevisiae Anti-Longevity Increase ERV2
34595 esc extra sexcombs Drosophila melanogaster Anti-Longevity 59% Increase esc
851965 ESC2 Establishment of Silent Chromatin Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ESC2
34903 esg escargot Drosophila melanogaster Anti-Longevity 21% Increase esg
853971 ESL2 Est1A/B-Smg6/5-Like Saccharomyces cerevisiae Necessary For Fitness Decrease ESL2
852314 ETR1 2-Enoyl Thioester Reductase Saccharomyces cerevisiae Necessary For Fitness 45% Decrease ETR1
180927 ets-4 ETS class transcription factor Caenorhabditis elegans Anti-Longevity 40% Increase ets-4
180702 ets-9 Protein ETS-9 Caenorhabditis elegans Pro-Longevity 23% Decrease ets-9
852130 EUG1 ER protein Unnecessary for Growth Saccharomyces cerevisiae Anti-Longevity Increase and Decrease EUG1
173069 exo-3 EXOnuclease Caenorhabditis elegans Pro-Longevity 20% Decrease exo-3
854198 EXO1 EXOnuclease Saccharomyces cerevisiae Necessary For Fitness Decrease EXO1
186604 exos-3 EXOSome (multiexonuclease complex) component Caenorhabditis elegans Anti-Longevity 12% Increase exos-3
178020 F01G4.6 Phosphate carrier protein, mitochondrial Caenorhabditis elegans Anti-Longevity 12% Increase F01G4.6
176285 F02A9.4 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Caenorhabditis elegans Anti-Longevity 13% Increase F02A9.4
177674 F08B4.7 Protein F08B4.7 Caenorhabditis elegans Anti-Longevity 21% Increase F08B4.7
175767 F09F7.3 Protein F09F7.3 Caenorhabditis elegans Anti-Longevity 8% Increase F09F7.3
175766 F09F7.4 hypothetical protein Caenorhabditis elegans Anti-Longevity 11% Increase F09F7.4
175764 F09F7.5 Protein F09F7.5 Caenorhabditis elegans Anti-Longevity Increase F09F7.5
184367 F11G11.13 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase F11G11.13
184407 F13B6.1 Protein F13B6.1 Caenorhabditis elegans Anti-Longevity 50% Increase F13B6.1
172478 F13G3.7 Protein F13G3.7 Caenorhabditis elegans Anti-Longevity 25% Increase F13G3.7
172752 F14B4.3 Protein F14B4.3 Caenorhabditis elegans Anti-Longevity 15% Increase F14B4.3
184523 F15B9.6 hypothetical protein Caenorhabditis elegans Anti-Longevity 17% Increase F15B9.6
184528 F15D3.8 hypothetical protein Caenorhabditis elegans Anti-Longevity 10% Increase F15D3.8
178181 F19B6.1 Protein F19B6.1 Caenorhabditis elegans Anti-Longevity 35% Increase F19B6.1
174019 F21H12.1 Protein F21H12.1 Caenorhabditis elegans Anti-Longevity Increase F21H12.1
184826 F22D3.5 hypothetical protein Caenorhabditis elegans Anti-Longevity 10% Increase F22D3.5
184916 F25B3.5 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase F25B3.5
172525 F26A3.4 Protein F26A3.4 Caenorhabditis elegans Anti-Longevity 27% Increase F26A3.4
259393 F26E4.4 Protein F26E4.4 Caenorhabditis elegans Anti-Longevity 17% Increase F26E4.4
3565338 F26E4.6 Protein F26E4.6 Caenorhabditis elegans Anti-Longevity 60% Increase F26E4.6
172111 F28B3.5 Protein F28B3.5 Caenorhabditis elegans Anti-Longevity 30% Increase F28B3.5
177549 F33D4.5 Protein F33D4.5 Caenorhabditis elegans Anti-Longevity 57% Increase F33D4.5
185238 F33H2.8 Protein F33H2.8 Caenorhabditis elegans Pro-Longevity 36% Decrease F33H2.8
174229 F35D2.3 Protein F35D2.3 Caenorhabditis elegans Anti-Longevity Increase F35D2.3
172692 F36A2.7 hypothetical protein Caenorhabditis elegans Anti-Longevity 80% Increase F36A2.7
177145 F37C4.4 Protein F37C4.4 Caenorhabditis elegans Pro-Longevity Decrease F37C4.4
174702 F40F8.5 Protein F40F8.5 Caenorhabditis elegans Anti-Longevity Increase F40F8.5
185645 F42A6.1 hypothetical protein Caenorhabditis elegans Anti-Longevity 22% Increase F42A6.1
181214 F42G10.1 Protein F42G10.1 Caenorhabditis elegans Anti-Longevity Increase F42G10.1
176769 F45G2.8 Mitochondrial import inner membrane translocase subunit tim-16 Caenorhabditis elegans Pro-Longevity 8% Decrease F45G2.8
174992 F45H10.2 hypothetical protein Caenorhabditis elegans Anti-Longevity 40% Increase F45H10.2
177752 F49C12.9 Protein F49C12.9 Caenorhabditis elegans Anti-Longevity 19% Increase F49C12.9
178381 F55B11.1 Protein F55B11.1 Caenorhabditis elegans Anti-Longevity Increase F55B11.1
178383 F55B11.3 Protein F55B11.3 Caenorhabditis elegans Anti-Longevity Increase F55B11.3
3565591 F55B11.5 Protein F55B11.5 Caenorhabditis elegans Anti-Longevity Increase F55B11.5
6418597 F56H1.7 F56H1.7 Caenorhabditis elegans Pro-Longevity 25% Decrease F56H1.7
172376 F57B10.3 Protein F57B10.3 Caenorhabditis elegans Anti-Longevity 20% Increase F57B10.3
177386 F58F9.7 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase F58F9.7
3772232 fabp fatty acid bindin protein Drosophila melanogaster Pro-Longevity 81% Increase fabp
850939 FAR10 Factor ARrest Saccharomyces cerevisiae Anti-Longevity Increase FAR10
850559 FAR7 Factor ARrest Saccharomyces cerevisiae Anti-Longevity Increase and Decrease FAR7
855044 FAR8 Factor ARrest Saccharomyces cerevisiae Anti-Longevity Increase FAR8
177819 fat-4 Delta(5) fatty acid desaturase fat-4 Caenorhabditis elegans Anti-Longevity 25% Increase fat-4
179100 fat-7 FATty acid desaturase Caenorhabditis elegans Pro-Longevity Decrease fat-7
852329 FAT1 FATty acid transporter Saccharomyces cerevisiae Necessary For Fitness Decrease FAT1
266822 fbp-1 fructose-1,6-bisphosphatase Caenorhabditis elegans Anti-Longevity Increase fbp-1
851092 FBP1 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for gluc Saccharomyces cerevisiae Anti-Longevity Decrease FBP1
189476 fbxa-121 F-box A protein Caenorhabditis elegans Pro-Longevity Decrease fbxa-121
185954 fbxa-188 F-box A protein Caenorhabditis elegans Anti-Longevity 13% Increase fbxa-188
190489 fbxa-220 F-box A protein Caenorhabditis elegans Anti-Longevity 25% Increase fbxa-220
856175 FCY1 FluoroCYtosine resistance Saccharomyces cerevisiae Anti-Longevity Increase FCY1
856783 FCY2 FluoroCYtosine resistance Saccharomyces cerevisiae Anti-Longevity Increase FCY2
856788 FCY21 FluoroCYtosine resistance Saccharomyces cerevisiae Anti-Longevity Increase FCY21
855080 FET3 FErrous Transport Saccharomyces cerevisiae Necessary For Fitness Decrease FET3
56636 Fgf21 fibroblast growth factor 21 Mus musculus Pro-Longevity 36% Increase Fgf21
64654 Fgf23 Fibroblast growth factor 23 Mus musculus Pro-Longevity Decrease Fgf23
173525 fgt-1 Facilitated Glucose Transporter Caenorhabditis elegans Anti-Longevity 25% Increase fgt-1
31845 fh frataxin homolog Drosophila melanogaster Pro-Longevity 35% Increase fh
855392 FIG4 Factor-Induced Gene Saccharomyces cerevisiae Necessary For Fitness 30% Decrease FIG4
851708 FIN1 Filaments In between Nuclei Saccharomyces cerevisiae Necessary For Fitness 30% Decrease FIN1
854745 FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) Saccharomyces cerevisiae Anti-Longevity Increase and Decrease FIS1
43383 fkh fork head Drosophila melanogaster Pro-Longevity 14% Increase fkh
177340 fkh-7 ForKHead transcription factor family Caenorhabditis elegans Anti-Longevity Increase fkh-7
851120 FLD1 Few Lipid Droplets Saccharomyces cerevisiae Necessary For Fitness Decrease FLD1
854709 FMC1 Formation of Mitochondrial Complexes Saccharomyces cerevisiae Necessary For Fitness Decrease FMC1
177958 fmo-2 Dimethylaniline monooxygenase [N-oxide-forming] Caenorhabditis elegans Pro-Longevity 20% Increase fmo-2
851642 FMP16 Found in Mitochondrial Proteome Saccharomyces cerevisiae Necessary For Fitness 40% Decrease FMP16
853923 FMP46 Found in Mitochondrial Proteome Saccharomyces cerevisiae Necessary For Fitness 20% Decrease FMP46
852270 FMT1 Formyl-Methionyl-tRNA Transformylase Saccharomyces cerevisiae Necessary For Fitness Decrease FMT1
14268 Fn1 Fibronectin 1 Mus musculus Pro-Longevity Decrease Fn1
851688 FOB1 Fob1p Saccharomyces cerevisiae Anti-Longevity 50% Increase FOB1
853878 FOX2 Fatty acid OXidation Saccharomyces cerevisiae Necessary For Fitness 30% Decrease FOX2
14235 Foxm1 Forkhead box M1 Mus musculus Pro-Longevity Decrease Foxm1
41709 foxo Forkhead box, sub-group O Drosophila melanogaster Pro-Longevity 33% Increase foxo
850675 FRE6 Ferric REductase 6 Saccharomyces cerevisiae Anti-Longevity 14% Increase FRE6
174002 frh-1 FRataxin (involved in human Friedrich's ataxia) Homolog Caenorhabditis elegans Unclear Increase and Decrease frh-1
2541227 frp2 ferric-chelate reductase 2 Schizosaccharomyces pombe Anti-Longevity Increase frp2
856888 FTR1 Fe TRansporter Saccharomyces cerevisiae Necessary For Fitness Decrease FTR1
181348 ftt-2 Fourteen-Three-Three family Caenorhabditis elegans Pro-Longevity Increase and Decrease ftt-2
855866 FUM1 FUMarase Saccharomyces cerevisiae Necessary For Fitness Decrease FUM1
851196 FUN12 Function Unknown Now Saccharomyces cerevisiae Necessary For Fitness 40% Decrease FUN12
45374 fwd four wheel drive Drosophila melanogaster Pro-Longevity 9% Increase fwd
14297 Fxn frataxin Mus musculus Pro-Longevity Decrease Fxn
852638 FZF1 Five Zinc Fingers Saccharomyces cerevisiae Anti-Longevity 66% Increase FZF1
266859 fzy-1 FiZzY (CDC20 protein family) homolog Caenorhabditis elegans Anti-Longevity 25% Increase fzy-1
44819 g garnet Drosophila melanogaster Pro-Longevity Decrease g
2539 G6PD glucose-6-phosphate dehydrogenase Mus musculus Pro-Longevity 14% Increase G6PD
35646 Gadd45 CG11086 gene product from transcript CG11086-RA Drosophila melanogaster Pro-Longevity 77% Increase Gadd45
854954 GAL80 GALactose metabolism Saccharomyces cerevisiae Necessary For Fitness Decrease GAL80
181646 gas-1 General Anaesthetic Sensitivity abnormal Caenorhabditis elegans Unannotated Decrease gas-1
855355 GAS1 Glycophospholipid-Anchored Surface protein Saccharomyces cerevisiae Necessary For Fitness 20% Decrease GAS1
53581 Gclc Glutamate-cysteine ligase catalytic subunit Drosophila melanogaster Pro-Longevity 50% Increase Gclc
248194 Gclm Glutamate-cysteine ligase modifier subunit Drosophila melanogaster Pro-Longevity 24% Increase Gclm
851877 GCN2 General Control Nonderepressible Saccharomyces cerevisiae Anti-Longevity Increase and Decrease GCN2
856709 GCN4 General Control Nonderepressible Saccharomyces cerevisiae Anti-Longevity Increase and Decrease GCN4
853167 GCN5 Histone acetyltransferase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease GCN5
178237 gcy-18 Guanylyl CYclase Caenorhabditis elegans Anti-Longevity 25% Increase gcy-18
172051 gcy-28 Guanylyl CYclase Caenorhabditis elegans Anti-Longevity Increase gcy-28
191644 gcy-6 Guanylyl CYclase Caenorhabditis elegans Anti-Longevity 25% Increase gcy-6
23886 Gdf15 growth differentiation factor 15 Mus musculus Pro-Longevity 43% Increase Gdf15
178130 gdh-1 Glutamate dehydrogenase Caenorhabditis elegans Anti-Longevity 11% Increase gdh-1
851237 GDH3 Glutamate DeHydrogenase Saccharomyces cerevisiae Necessary For Fitness Decrease GDH3
178402 gdi-1 GDI (RabGDP Dissociation Inhibitor) family Caenorhabditis elegans Pro-Longevity Decrease gdi-1
180951 gei-15 GEX Interacting protein Caenorhabditis elegans Anti-Longevity 13% Increase gei-15
175195 gei-4 Protein GEI-4 Caenorhabditis elegans Pro-Longevity 27% Decrease gei-4
854380 GEP3 GEnetic interactors of Prohibitins Saccharomyces cerevisiae Necessary For Fitness Decrease GEP3
856817 GET2 Guided Entry of Tailanchored proteins Saccharomyces cerevisiae Necessary For Fitness Decrease GET2
850321 GFD2 Great for Full DEAD box protein activity Saccharomyces cerevisiae Necessary For Fitness Decrease GFD2
14599 Gh Growth hormone Mus musculus Anti-Longevity Decrease Gh
14600 Ghr Growth hormone receptor Mus musculus Anti-Longevity 40% Increase Ghr
14601 Ghrh growth hormone releasing hormone Mus musculus Anti-Longevity 46% Increase Ghrh
14602 Ghrhr Growth hormone releasing hormone receptor Mus musculus Anti-Longevity 20% Increase Ghrhr
2539240 ght5 hexose transporter Ght5 Schizosaccharomyces pombe Anti-Longevity Increase ght5
850318 GID7 Glucose Induced Degradation deficient Saccharomyces cerevisiae Necessary For Fitness Decrease GID7
855166 GID8 Glucose Induced Degradation deficient Saccharomyces cerevisiae Necessary For Fitness Decrease GID8
40201 gig gigas Drosophila melanogaster Pro-Longevity Increase gig
852119 GIN4 Growth Inhibitory Saccharomyces cerevisiae Necessary For Fitness 35% Decrease GIN4
851670 GIS1 GIg1-2 Suppressor Saccharomyces cerevisiae Anti-Longevity 25% Increase GIS1
36447 GLaz Glial Lazarillo Drosophila melanogaster Pro-Longevity Increase and Decrease GLaz
177358 glf-1 GaLactoFuranose synthesis (UGM, UDP-galactopyranose mutase) Caenorhabditis elegans Pro-Longevity 49% Decrease glf-1
850317 GLK1 GLucoKinase Saccharomyces cerevisiae Necessary For Fitness 15% Decrease GLK1
856763 GLN3 Gln3p Saccharomyces cerevisiae Anti-Longevity Increase and Decrease GLN3
176286 glp-1 abnormal Germ Line Proliferation Caenorhabditis elegans Anti-Longevity 33% Increase glp-1
33386 GlyP Glycogen phosphorylase Drosophila melanogaster Anti-Longevity 17% Increase GlyP
41823 GlyS Glycogen synthase Drosophila melanogaster Anti-Longevity 10% Increase GlyS
851166 GMC2 Grand Meiotic recombination Cluster Saccharomyces cerevisiae Necessary For Fitness 50% Decrease GMC2
2764 GMFB glia maturation factor beta Mus musculus Anti-Longevity 6% Decrease GMFB
41561 Gnmt Glycine N-methyltransferase Drosophila melanogaster Pro-Longevity Increase Gnmt
172505 goa-1 G protein,O, Alpha subunit Caenorhabditis elegans Pro-Longevity 33% Decrease goa-1
179546 gpa-1 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity Increase and Decrease gpa-1
179075 gpa-10 G Protein, Alpha subunit Caenorhabditis elegans Pro-Longevity 10% Decrease gpa-10
173759 gpa-11 G Protein, Alpha subunit Caenorhabditis elegans Pro-Longevity 25% Increase gpa-11
172645 gpa-15 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity 20% Decrease gpa-15
179219 gpa-2 G Protein, Alpha subunit Caenorhabditis elegans Pro-Longevity Increase and Decrease gpa-2
179319 gpa-3 G Protein, Alpha subunit Caenorhabditis elegans Pro-Longevity 15% Decrease gpa-3
180527 gpa-5 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity Increase and Decrease gpa-5
181442 gpa-6 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity 10% Increase gpa-6
179731 gpa-8 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity Increase and Decrease gpa-8
191659 gpa-9 G Protein, Alpha subunit Caenorhabditis elegans Unannotated gpa-9
856741 GPA2 Gpa2p Saccharomyces cerevisiae Anti-Longevity Increase and Decrease GPA2
854553 GPB1 Gpb1p Saccharomyces cerevisiae Necessary For Fitness Decrease GPB1
181424 gpc-1 G Protein, Gamma subunit Caenorhabditis elegans Anti-Longevity 10% Increase gpc-1
3565504 gpd-2 GPD (glyceraldehyde 3-phosphate dehydrogenase) Caenorhabditis elegans Anti-Longevity Increase gpd-2
180601 gpd-3 Protein GPD-3 Caenorhabditis elegans Anti-Longevity 5% Increase gpd-3
33824 Gpdh Glycerol 3 phosphate dehydrogenase Drosophila melanogaster Anti-Longevity 20% Increase Gpdh
173227 gpi-1 Glucose-6-Phosphate Isomerase Caenorhabditis elegans Anti-Longevity Increase gpi-1
851527 GPR1 Gpr1p Saccharomyces cerevisiae Anti-Longevity 50% Increase GPR1
853941 GPT2 Glycerol-3-Phosphate acylTransferase Saccharomyces cerevisiae Necessary For Fitness Decrease GPT2
852546 GPX2 Glutathione PeroXidase Saccharomyces cerevisiae Necessary For Fitness 35% Decrease GPX2
625249 Gpx4 Glutathione peroxidase 4 Mus musculus Anti-Longevity 7% Increase Gpx4
38453 Gr63a Gustatory receptor 63a Drosophila melanogaster Anti-Longevity 30% Increase Gr63a
856504 GRE3 trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) Saccharomyces cerevisiae Anti-Longevity 100% Increase GRE3
176843 grl-19 GRound-Like (grd related) Caenorhabditis elegans Anti-Longevity 27% Increase grl-19
176827 grld-1 hypothetical protein Caenorhabditis elegans Anti-Longevity 10% Increase grld-1
14824 Grn granulin Mus musculus Pro-Longevity Decrease Grn
175725 gro-1 abnormal GROwth rate Caenorhabditis elegans Unannotated 29% Increase gro-1
171687 gsa-1 G protein, Subunit Alpha Caenorhabditis elegans Pro-Longevity 84% Decrease gsa-1
2542652 gsk3 serine/threonine protein kinase Schizosaccharomyces pombe Anti-Longevity Increase gsk3
606496 Gsk3a glycogen synthase kinase 3 alpha Mus musculus Pro-Longevity Decrease Gsk3a
178725 gst-10 Glutathione S-Transferase Caenorhabditis elegans Pro-Longevity Increase and Decrease gst-10
187537 gst-5 Glutathione S-Transferase Caenorhabditis elegans Pro-Longevity Decrease gst-5
14860 Gsta4 glutathione S-transferase, alpha 4 Mus musculus Anti-Longevity 13% Increase Gsta4
36927 GstS1 Glutathione S transferase S1 Drosophila melanogaster Pro-Longevity 33% Increase GstS1
850962 GSY2 Glycogen SYnthase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease GSY2
854918 GTR1 GTp binding protein Resemblance 1 Saccharomyces cerevisiae Necessary For Fitness 36% Decrease GTR1
854651 GUT2 Glycerol UTilization Saccharomyces cerevisiae Pro-Longevity 25% Increase GUT2
854236 GYP1 Gtpase-activating protein for YPt1p Saccharomyces cerevisiae Necessary For Fitness Decrease GYP1
2539298 gyp3 GTPase-activating protein gyp3 Schizosaccharomyces pombe Anti-Longevity Increase gyp3
186700 H06H21.8 Protein H06H21.8 Caenorhabditis elegans Anti-Longevity Increase H06H21.8
173134 H28O16.1 Protein H28O16.1 Caenorhabditis elegans Anti-Longevity 27% Increase H28O16.1
852260 HAP3 Heme Activator Protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease HAP3
853751 HAP4 Hap4p Saccharomyces cerevisiae Pro-Longevity Increase and Decrease HAP4
856106 HAT1 Histone AcetylTransferase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease HAT1
856654 HAT2 Hat2p Saccharomyces cerevisiae Unannotated 30% Increase HAT2
177560 hcf-1 human HCF1 related Caenorhabditis elegans Anti-Longevity 40% Increase hcf-1
850429 HCM1 Hcm1p Saccharomyces cerevisiae Pro-Longevity 30% Increase HCM1
855710 HDA1 Histone DeAcetylase Saccharomyces cerevisiae Anti-Longevity Increase HDA1
851889 HDA2 Histone DeAcetylase Saccharomyces cerevisiae Necessary For Fitness Decrease HDA2
36011 hebe hebe gene product from transcript hebe-RD Drosophila melanogaster Pro-Longevity 24% Increase hebe
174333 hel-1 Spliceosome RNA helicase DDX39B homolog Caenorhabditis elegans Pro-Longevity 9% Decrease hel-1
15201 Hells Proliferation associated SNF-2-like gene Mus musculus Pro-Longevity Decrease Hells
855338 HER2 Hmg2p ER Remodeling Saccharomyces cerevisiae Necessary For Fitness Decrease HER2
854412 HES1 Hes1p Saccharomyces cerevisiae Anti-Longevity 25% Decrease HES1
45875 Hex-A Hexokinase A Drosophila melanogaster Anti-Longevity 10% Increase Hex-A
44008 Hex-C Hexokinase C Drosophila melanogaster Anti-Longevity Increase Hex-C
855247 HFA1 acetyl-CoA carboxylase HFA1 Saccharomyces cerevisiae Necessary For Fitness Decrease HFA1
190374 hhat-2 Homolog of Hedgehog AcylTransferase Caenorhabditis elegans Anti-Longevity 50% Increase hhat-2
2542467 hht1 histone H3 h3.1 Schizosaccharomyces pombe Anti-Longevity Increase hht1
180359 hif-1 HIF (Hypoxia Inducible Factor) homologa Caenorhabditis elegans Unclear 34% Increase hif-1
178201 him-6 High Incidence of Males (increased X chromosome loss) Caenorhabditis elegans Pro-Longevity Decrease him-6
852275 HIR1 HIstone Regulation Saccharomyces cerevisiae Anti-Longevity Increase and Decrease HIR1
854203 HIR2 HIstone Regulation Saccharomyces cerevisiae Anti-Longevity Increase and Decrease HIR2
853605 HIR3 HIstone Regulation Saccharomyces cerevisiae Anti-Longevity Increase and Decrease HIR3
179341 his-37 Histone H4 Caenorhabditis elegans Anti-Longevity 4% Increase his-37
181057 his-71 HIStone Caenorhabditis elegans Pro-Longevity 19% Decrease his-71
852550 HIS7 HIStidine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease HIS7
35169 hk hook Drosophila melanogaster Pro-Longevity Decrease hk
181499 hlb-1 Protein HLB-1 Caenorhabditis elegans Pro-Longevity Decrease hlb-1
177157 hlh-30 Helix Loop Helix Caenorhabditis elegans Pro-Longevity 20% Increase hlh-30
176052 hmg-4 Protein HMG-4 Caenorhabditis elegans Anti-Longevity 6% Increase hmg-4
854058 HMI1 Helicase in MItochondria Saccharomyces cerevisiae Necessary For Fitness Decrease HMI1
852322 HMT1 HnRNP MethylTransferase Saccharomyces cerevisiae Anti-Longevity 50% Increase HMT1
852803 HNM1 Hyper-resistance to Nitrogen Mustard Saccharomyces cerevisiae Anti-Longevity Increase HNM1
11991 Hnrnpd heterogeneous nuclear ribonucleoprotein D Mus musculus Pro-Longevity Decrease Hnrnpd
854432 HNT3 Histidine triad NucleoTide-binding Saccharomyces cerevisiae Necessary For Fitness Decrease HNT3
32080 hop hopscotch Drosophila melanogaster Pro-Longevity Increase and Decrease hop
186781 hpa-1 hypothetical protein Caenorhabditis elegans Anti-Longevity 30% Increase hpa-1
188415 hpa-2 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase hpa-2
180695 hpk-1 Homeodomain interacting Protein Kinase Caenorhabditis elegans Pro-Longevity 37% Decrease hpk-1
176506 hpl-2 Protein HPL-2 Caenorhabditis elegans Anti-Longevity 17% Increase hpl-2
3565786 hpo-31 Protein HPO-31 Caenorhabditis elegans Pro-Longevity 52% Decrease hpo-31
852008 HPT1 Hypoxanthine guanine PhosphoribosylTransferase Saccharomyces cerevisiae Anti-Longevity Increase HPT1
855728 HRB1 Hypothetical RNA-Binding protein Saccharomyces cerevisiae Anti-Longevity 20% Increase HRB1
854149 HRD1 HMG-coA Reductase Degradation Saccharomyces cerevisiae Anti-Longevity Increase and Decrease HRD1
850904 HRD3 HMG-coA Reductase Degradation Saccharomyces cerevisiae Necessary For Fitness Decrease HRD3
177101 hrp-1 human HnRNP A1 homolog Caenorhabditis elegans Anti-Longevity 49% Increase hrp-1
850786 HRT3 High level expression Reduces Ty3 transposition Saccharomyces cerevisiae Necessary For Fitness 50% Decrease HRT3
32133 Hsc70-3 Heat shock protein cognate 3 Drosophila melanogaster Pro-Longevity 27% Increase Hsc70-3
856387 HSE1 Has Symptoms of class E mutants; resembles Hbp, Stam and East Saccharomyces cerevisiae Anti-Longevity Increase and Decrease HSE1
173078 hsf-1 Heat shock transcription factor 1 Caenorhabditis elegans Pro-Longevity Increase and Decrease hsf-1
177778 hsp-12.6 Heat Shock Protein Caenorhabditis elegans Pro-Longevity 16% Decrease hsp-12.6
179286 hsp-16.1 Heat Shock Protein Caenorhabditis elegans Pro-Longevity Increase and Decrease hsp-16.1
179287 hsp-16.48 Heat Shock Protein Caenorhabditis elegans Pro-Longevity Increase hsp-16.48
179288 hsp-16.49 Heat Shock Protein Caenorhabditis elegans Pro-Longevity Increase and Decrease hsp-16.49
174203 hsp-4 Heat Shock Protein Caenorhabditis elegans Pro-Longevity Decrease hsp-4
178873 hsp-6 Heat shock 70kDa protein 9B (mortalin-2) Caenorhabditis elegans Pro-Longevity Increase and Decrease hsp-6
850633 HSP104 chaperone ATPase HSP104 Saccharomyces cerevisiae Necessary For Fitness 40% Decrease HSP104
3772576 Hsp22 Heat shock protein 22 Drosophila melanogaster Unclear Increase and Decrease Hsp22
39075 Hsp26 Heat shock protein 26 Drosophila melanogaster Pro-Longevity 30% Increase Hsp26
39078 Hsp27 Heat shock protein 27 Drosophila melanogaster Pro-Longevity 30% Increase Hsp27
39071 Hsp67Bc Heat shock gene 67Bc Drosophila melanogaster Pro-Longevity 6% Increase Hsp67Bc
42852 Hsp68 Heat shock protein 68 Drosophila melanogaster Pro-Longevity 20% Increase Hsp68
hsp70 Heat Shock Protein Drosophila melanogaster Pro-Longevity Increase hsp70
44921 Hsp70Ba Heat shock 70kDa protein 1A Drosophila melanogaster Unclear Increase and Decrease Hsp70Ba
854086 HST1 Homolog of SIR Two (SIR2) Saccharomyces cerevisiae Necessary For Fitness Decrease HST1
856092 HST2 Hst2p Saccharomyces cerevisiae Pro-Longevity Increase HST2
856464 HTD2 Hydroxyacyl-Thioester Dehydratase Saccharomyces cerevisiae Necessary For Fitness Decrease HTD2
172099 htp-3 Him-Three Paralog Caenorhabditis elegans Anti-Longevity 19% Increase htp-3
15551 Htr1b 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus Pro-Longevity Decrease Htr1b
64704 Htra2 HtrA serine peptidase 2 Mus musculus Pro-Longevity Decrease Htra2
15194 Htt Huntingtin Mus musculus Anti-Longevity 18% Increase Htt
171939 hus-1 human HUS1 related Caenorhabditis elegans Anti-Longevity 11% Increase hus-1
852639 HXK2 hexokinase 2 Saccharomyces cerevisiae Anti-Longevity 50% Increase HXK2
856496 HXT5 HeXose Transporter Saccharomyces cerevisiae Necessary For Fitness Decrease HXT5
177660 hyl-1 Homolog of Yeast Longevity gene Caenorhabditis elegans Pro-Longevity 10% Decrease hyl-1
853586 IBA57 Iron-sulfur cluster assembly factor for Biotin synthase and Aconitase-like mitochondrial proteins Saccharomyces cerevisiae Anti-Longevity 50% Increase IBA57
856794 ICL1 IsoCitrate Lyase Saccharomyces cerevisiae Necessary For Fitness Decrease ICL1
177775 idh-1 Protein IDH-1 Caenorhabditis elegans Anti-Longevity Increase idh-1
855691 IDH1 Isocitrate DeHydrogenase Saccharomyces cerevisiae Anti-Longevity 15% Increase IDH1
854303 IDH2 Idh2p Saccharomyces cerevisiae Anti-Longevity 30% Increase IDH2
172655 idha-1 Protein IDHA-1 Caenorhabditis elegans Anti-Longevity Increase idha-1
851493 IDP1 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae Anti-Longevity 15% Increase IDP1
850871 IDP2 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae Anti-Longevity Increase and Decrease IDP2
855723 IDP3 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae Anti-Longevity Increase and Decrease IDP3
181699 ifa-3 Intermediate filament protein ifa-3 Caenorhabditis elegans Anti-Longevity Increase ifa-3
187585 ifd-1 Intermediate filament protein ifd-1 Caenorhabditis elegans Anti-Longevity Increase ifd-1
176755 ife-1 Initiation Factor 4E (eIF4E) family Caenorhabditis elegans Anti-Longevity Increase ife-1
180393 ife-2 Initiation Factor 4E (eIF4E) family Caenorhabditis elegans Anti-Longevity Increase ife-2
176373 iff-1 Initiation Factor Five (eIF-5A) homologs Caenorhabditis elegans Anti-Longevity Increase iff-1
174322 ifg-1 Initiation Factor 4G (eIF4G) family Caenorhabditis elegans Anti-Longevity 55% Increase ifg-1
181182 ifp-1 Intermediate filament protein ifp-1 Caenorhabditis elegans Anti-Longevity Increase ifp-1
189055 ifta-2 IntraFlagellar Transport Associated Caenorhabditis elegans Anti-Longevity 50% Increase ifta-2
172584 iftb-1 eIFTwoBeta (eIF2beta translation initiation factor) Caenorhabditis elegans Anti-Longevity Increase iftb-1
16000 Igf1 Insulin-like growth factor 1 Mus musculus Unclear Increase and Decrease Igf1
16001 Igf1r Insulin-like growth factor 1 receptor Mus musculus Anti-Longevity 40% Increase Igf1r
184720 iglr-1 iglr-1 Caenorhabditis elegans Anti-Longevity 34% Increase iglr-1
16150 Ikbkb inhibitor of kappaB kinase beta Mus musculus Anti-Longevity 23% Increase Ikbkb
851100 IKI3 Insensitive to KIller toxin Saccharomyces cerevisiae Anti-Longevity Increase IKI3
53573 Ilk Integrin linked kinase Drosophila melanogaster Anti-Longevity 63% Increase Ilk
39150 Ilp2 Insulin-related peptide Drosophila melanogaster Anti-Longevity 47% Increase Ilp2
31220 Ilp6 Insulin-like peptide 6 Drosophila melanogaster Pro-Longevity 16% Increase Ilp6
850413 IMG1 mitochondrial 54S ribosomal protein IMG1 Saccharomyces cerevisiae Anti-Longevity 23% Increase IMG1
850434 IMG2 mitochondrial 54S ribosomal protein IMG2 Saccharomyces cerevisiae Anti-Longevity 28% Increase IMG2
38513 ImpL2 Ecdysone-inducible gene L2 Drosophila melanogaster Pro-Longevity 23% Increase ImpL2
173001 impt-1 Protein IMPACT homolog Caenorhabditis elegans Anti-Longevity 16% Increase impt-1
32343 inaE inactivation no afterpotential E Drosophila melanogaster Pro-Longevity 73% Increase inaE
40049 Indy I'm not dead yet protein Drosophila melanogaster Anti-Longevity 92% Increase Indy
175966 inf-1 INitiation Factor Caenorhabditis elegans Unclear Increase and Decrease inf-1
856442 INM1 INositol Monophosphatase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease INM1
851881 INM2 INositol Monophosphatase Saccharomyces cerevisiae Necessary For Fitness 70% Decrease INM2
854042 INO4 INOsitol requiring Saccharomyces cerevisiae Necessary For Fitness Decrease INO4
854815 INP51 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae Anti-Longevity 10% Increase INP51
854276 INP53 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease INP53
854089 INP54 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease INP54
42549 InR Insulin-like 1 receptor Drosophila melanogaster Anti-Longevity 85% Increase InR
177936 ins-1 INSulin related Caenorhabditis elegans Pro-Longevity 25% Increase ins-1
172600 ins-18 INSulin related Caenorhabditis elegans Anti-Longevity Increase ins-18
191689 ins-21 INSulin related Caenorhabditis elegans Anti-Longevity Increase ins-21
191688 ins-7 INSulin related Caenorhabditis elegans Anti-Longevity 12% Increase ins-7
16337 Insr Insulin receptor Mus musculus Anti-Longevity 33% Increase Insr
172488 inx-14 INneXin Caenorhabditis elegans Anti-Longevity Increase inx-14
178101 inx-8 INneXin Caenorhabditis elegans Anti-Longevity 19% Increase inx-8
191694 inx-9 INneXin Caenorhabditis elegans Anti-Longevity 28% Increase inx-9
851910 IPK1 Inositol Polyphosphate Kinase Saccharomyces cerevisiae Anti-Longevity 40% Increase IPK1
851644 IPT1 InositolPhosphoTransferase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease IPT1
174305 ire-1 IRE1 kinase related Caenorhabditis elegans Pro-Longevity 20% Decrease ire-1
42358 Ire1 Inositol-requiring enzyme-1 Drosophila melanogaster Pro-Longevity Decrease Ire1
16367 Irs1 insulin receptor substrate 1 Mus musculus Anti-Longevity 18% Increase Irs1
384783 Irs2 insulin receptor substrate 2 Mus musculus Anti-Longevity 18% Increase Irs2
856739 ISC1 Inositol phosphoSphingolipid phospholipase C Saccharomyces cerevisiae Pro-Longevity Decrease ISC1
856067 ISM1 Isoleucyl tRNA Synthetase of Mitochondria Saccharomyces cerevisiae Anti-Longevity Increase and Decrease ISM1
177609 isp-1 Iron-Sulfur Protein Caenorhabditis elegans Anti-Longevity 60% Increase isp-1
852547 ISW1 Imitation SWitch subfamily Saccharomyces cerevisiae Anti-Longevity Increase and Decrease ISW1
854480 ISW2 Isw2p Saccharomyces cerevisiae Anti-Longevity 24% Increase ISW2
852744 ITC1 Itc1p Saccharomyces cerevisiae Anti-Longevity 18% Increase ITC1
177546 itr-1 Inositol Triphosphate Receptor Caenorhabditis elegans Pro-Longevity 53% Increase itr-1
850710 IZH3 Implicated in Zinc Homeostasis Saccharomyces cerevisiae Necessary For Fitness Decrease IZH3
53578 Jafrac1 Thioredoxin peroxidase 1 Drosophila melanogaster Pro-Longevity 29% Increase Jafrac1
34624 JhI-21 CG12317-PA Drosophila melanogaster Anti-Longevity 32% Increase JhI-21
856174 JID1 DnaJ protein Involved in ER-associated Degradation Saccharomyces cerevisiae Necessary For Fitness Decrease JID1
180810 jkk-1 JNK Kinase Caenorhabditis elegans Unannotated Decrease jkk-1
175080 jmjd-2 Lysine-specific demethylase 4 Caenorhabditis elegans Anti-Longevity 13% Increase jmjd-2
177460 jnk-1 Jun N-terminal Kinase Caenorhabditis elegans Pro-Longevity Increase and Decrease jnk-1
855339 JNM1 Just Nuclear Migration Saccharomyces cerevisiae Necessary For Fitness Decrease JNM1
16478 Jund Jun proto-oncogene related gene d Mus musculus Pro-Longevity 17% Decrease Jund
186841 K01C8.7 Protein K01C8.7 Caenorhabditis elegans Anti-Longevity 20% Increase K01C8.7
177624 K07H8.1 Protein K07H8.1 Caenorhabditis elegans Anti-Longevity Increase K07H8.1
187128 K07H8.8 Protein K07H8.8 Caenorhabditis elegans Anti-Longevity 22% Increase K07H8.8
176814 K08E3.5 Protein K08E3.5 Caenorhabditis elegans Anti-Longevity Increase K08E3.5
173397 K10B4.3 Protein K10B4.3 Caenorhabditis elegans Anti-Longevity Increase K10B4.3
173349 K11B4.1 Protein K11B4.1 Caenorhabditis elegans Anti-Longevity 16% Increase K11B4.1
178892 K11D12.9 Protein K11D12.9 Caenorhabditis elegans Pro-Longevity Decrease K11D12.9
187337 K12H4.5 Protein K12H4.5 Caenorhabditis elegans Anti-Longevity 58% Increase K12H4.5
856263 KAR3 KARyogamy Saccharomyces cerevisiae Anti-Longevity 55% Increase KAR3
174161 kat-1 3-Ketoacyl-coA Thiolase Caenorhabditis elegans Pro-Longevity 30% Decrease kat-1
16491 Kcna3 Potassium voltage-gated channel, shaker-related subfamily, member 3 Mus musculus Anti-Longevity 22% Increase Kcna3
42062 Keap1 CG3962 gene product from transcript CG3962-RA Drosophila melanogaster Anti-Longevity 10% Increase Keap1
46027 kermit CG11546 Drosophila melanogaster Pro-Longevity 30% Decrease kermit
855483 KEX2 Killer EXpression defective Saccharomyces cerevisiae Necessary For Fitness Decrease KEX2
854681 KGD1 alpha-KetoGlutarate Dehydrogenase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease KGD1
16591 Kl Klotho Mus musculus Pro-Longevity Increase and Decrease Kl
175404 klf-1 Kruppel-Like Factor (zinc finger protein) Caenorhabditis elegans Pro-Longevity 15% Increase klf-1
177557 klo-1 hypothetical protein Caenorhabditis elegans Pro-Longevity 15% Decrease klo-1
184000 klo-2 hypothetical protein Caenorhabditis elegans Pro-Longevity 15% Decrease klo-2
40680 kra krasavietz Drosophila melanogaster Anti-Longevity 25% Increase kra
191275 kri-1 human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog Caenorhabditis elegans Pro-Longevity Decrease kri-1
2539653 ksp1 serine/threonine protein kinase Ksp1 (predicted) Schizosaccharomyces pombe Anti-Longevity Increase ksp1
852931 KSS1 Kss1p Saccharomyces cerevisiae Necessary For Fitness 33% Decrease KSS1
42063 kuk kugelkern Drosophila melanogaster Anti-Longevity Decrease kuk
180883 kynu-1 kynu-1 Caenorhabditis elegans Anti-Longevity 38% Increase kynu-1
249462 l(3)DTS3 lethal (3) DTS3 Drosophila melanogaster Anti-Longevity 42% Increase l(3)DTS3
46260 l(3)neo18 l(3)neo18 Drosophila melanogaster Anti-Longevity 24% Increase l(3)neo18
856386 LAG1 Ceramide synthase component Saccharomyces cerevisiae Anti-Longevity 50% Increase LAG1
854133 LAG2 Lag2p Saccharomyces cerevisiae Pro-Longevity 36% Increase LAG2
189370 lagr-1 LAG1 (yeast Longevity-Assurance Gene) Related Caenorhabditis elegans Pro-Longevity 10% Decrease lagr-1
172499 lars-2 Leucyl Amino-acyl tRNA Synthetase Caenorhabditis elegans Anti-Longevity Increase lars-2
853384 LAS21 Local Anestheticum Sensitive Saccharomyces cerevisiae Necessary For Fitness Decrease LAS21
855653 LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes Saccharomyces cerevisiae Pro-Longevity 20% Increase LAT1
179161 lbp-4 Lipid Binding Protein Caenorhabditis elegans Pro-Longevity Decrease lbp-4
172390 lbp-6 Lipid Binding Protein Caenorhabditis elegans Unclear Increase and Decrease lbp-6
191701 lbp-7 Lipid Binding Protein Caenorhabditis elegans Anti-Longevity Increase lbp-7
188761 lbp-8 Lipid Binding Protein Caenorhabditis elegans Pro-Longevity 30% Increase lbp-8
178686 lbp-9 Lipid Binding Protein Caenorhabditis elegans Pro-Longevity Decrease lbp-9
37482 LBR Lamin B receptor Drosophila melanogaster Anti-Longevity Decrease LBR
853307 LCB3 Long-Chain Base Saccharomyces cerevisiae Anti-Longevity Increase LCB3
856051 LCL1 Long Chronological Lifespan Saccharomyces cerevisiae Anti-Longevity Increase LCL1
850794 LCL2 Long Chronological Lifespan 2 Saccharomyces cerevisiae Anti-Longevity Increase LCL2
852795 LCL3 Long Chronological Lifespan 3 Saccharomyces cerevisiae Anti-Longevity Increase LCL3
181292 ldb-1 LIM domain Binding Protein Caenorhabditis elegans Pro-Longevity Decrease ldb-1
850351 LDB16 Low Dye Binding Saccharomyces cerevisiae Necessary For Fitness Decrease LDB16
854500 LDB19 Low Dye Binding Saccharomyces cerevisiae Necessary For Fitness Decrease LDB19
175058 lem-2 LEM domain protein Caenorhabditis elegans Pro-Longevity Decrease lem-2
174462 let-23 LEThal Caenorhabditis elegans Pro-Longevity Increase and Decrease let-23
172167 let-363 LEThal Caenorhabditis elegans Anti-Longevity 150% Increase let-363
178970 let-418 Protein let-418 Caenorhabditis elegans Anti-Longevity 25% Increase let-418
172088 let-502 LEThal Caenorhabditis elegans Pro-Longevity 30% Decrease let-502
178104 let-60 LEThal Caenorhabditis elegans Unannotated Increase let-60
172153 let-630 hypothetical protein Caenorhabditis elegans Anti-Longevity 18% Increase let-630
178120 let-653 LEThal Caenorhabditis elegans Pro-Longevity 13% Decrease let-653
12798012 let-7 let-7 Drosophila melanogaster Unannotated let-7
175934 let-765 LEThal Caenorhabditis elegans Pro-Longevity 27% Decrease let-765
179854 letm-1 LETM1 (Leucine zipper, EF-hand, TransMembrane mitochondrial protein) homolog Caenorhabditis elegans Anti-Longevity 21% Increase letm-1
850342 LEU2 LEUcine biosynthesis Saccharomyces cerevisiae Anti-Longevity Increase LEU2
851172 LEU3 LEUcine biosynthesis Saccharomyces cerevisiae Anti-Longevity Increase LEU3
174050 lgg-1 LC3, GABARAP and GATE-16 family Caenorhabditis elegans Pro-Longevity 43% Decrease lgg-1
853789 LHS1 Lumenal Hsp Seventy Saccharomyces cerevisiae Necessary For Fitness 50% Decrease LHS1
172893 lin-11 Protein LIN-11 Caenorhabditis elegans Pro-Longevity 9% Decrease lin-11
181337 lin-14 abnormal cell LINeage Caenorhabditis elegans Anti-Longevity 31% Increase lin-14
181662 lin-15B abnormal cell LINeage Caenorhabditis elegans Pro-Longevity 42% Decrease lin-15B
181400 lin-2 abnormal cell LINeage Caenorhabditis elegans Unclear Increase lin-2
174058 lin-23 abnormal cell LINeage Caenorhabditis elegans Pro-Longevity Decrease lin-23
172626 lin-28 Protein lin-28 Caenorhabditis elegans Anti-Longevity 20% Increase lin-28
178001 lin-3 abnormal cell LINeage Caenorhabditis elegans Pro-Longevity Decrease lin-3
266860 lin-4 abnormal cell LINeage Caenorhabditis elegans Pro-Longevity lin-4
178788 lin-40 abnormal cell LINeage Caenorhabditis elegans Pro-Longevity Increase and Decrease lin-40
174267 lin-5 Protein LIN-5 Caenorhabditis elegans Anti-Longevity 16% Increase lin-5
171739 lin-65 hypothetical protein Caenorhabditis elegans Pro-Longevity 24% Decrease lin-65
856561 LIN1 LINk Saccharomyces cerevisiae Anti-Longevity 40% Increase LIN1
191704 lip-1 Lateral-signal-Induced Phosphatase Caenorhabditis elegans Anti-Longevity 8% Increase lip-1
850940 LIP2 LIPoyl ligase Saccharomyces cerevisiae Necessary For Fitness Decrease LIP2
179046 lipl-4 LIPase Like Caenorhabditis elegans Pro-Longevity 55% Increase lipl-4
172687 lmn-1 nuclear LaMiN Caenorhabditis elegans Pro-Longevity 12% Decrease lmn-1
16905 Lmna lamin A Mus musculus Unclear Increase and Decrease Lmna
43130 Lnk CG17367 gene product from transcript CG17367-RC Drosophila melanogaster Anti-Longevity 33% Increase Lnk
850551 LOC1 LOCalization of ASH1 mRNA Saccharomyces cerevisiae Anti-Longevity 40% Increase LOC1
42672 loco locomotion defects Drosophila melanogaster Anti-Longevity Increase and Decrease loco
853630 LOS1 Loss Of Suppression Saccharomyces cerevisiae Necessary For Fitness Decrease LOS1
172037 lpd-5 LiPid Depleted Caenorhabditis elegans Anti-Longevity 17% Increase lpd-5
179477 lpd-9 LiPid Depleted Caenorhabditis elegans Anti-Longevity 10% Increase lpd-9
850527 LPD1 LiPoamide Dehydrogenase Saccharomyces cerevisiae Necessary For Fitness Decrease LPD1
181297 lpr-5 Protein LPR-5 Caenorhabditis elegans Pro-Longevity 16% Decrease lpr-5
853037 LSB1 Las Seventeen Binding protein Saccharomyces cerevisiae Anti-Longevity 30% Increase LSB1
850580 LSB3 Las Seventeen Binding protein Saccharomyces cerevisiae Anti-Longevity 40% Increase LSB3
853345 LSB6 Las Seventeen Binding protein Saccharomyces cerevisiae Anti-Longevity 50% Increase LSB6
854310 LSC1 succinate--CoA ligase (GDP-forming) subunit alpha Saccharomyces cerevisiae Necessary For Fitness Decrease LSC1
853159 LSC2 succinate--CoA ligase (GDP-forming) subunit beta Saccharomyces cerevisiae Necessary For Fitness Decrease LSC2
177988 lsm-7 LSM Sm-like protein Caenorhabditis elegans Pro-Longevity 24% Decrease lsm-7
851984 LSM6 Like SM Saccharomyces cerevisiae Necessary For Fitness Decrease LSM6
852948 LST7 Lethal with Sec Thirteen Saccharomyces cerevisiae Necessary For Fitness 40% Decrease LST7
3355130 lt light Drosophila melanogaster Pro-Longevity Decrease lt
184622 lys-10 LYSozyme Caenorhabditis elegans Anti-Longevity 20% Increase lys-10
178087 lys-6 LYSozyme Caenorhabditis elegans Anti-Longevity 13% Increase lys-6
173944 lys-8 LYSozyme Caenorhabditis elegans Pro-Longevity 29% Decrease lys-8
854852 LYS1 LYSine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease LYS1
854714 LYS12 Isocitrate dehydrogenase Saccharomyces cerevisiae Anti-Longevity Increase LYS12
2542118 lys7 alpha-aminoadipate reductase phosphopantetheinyl transferase Lys7 Schizosaccharomyces pombe Anti-Longevity Increase lys7
855786 LYS9 LYSine requiring Saccharomyces cerevisiae Anti-Longevity Increase and Decrease LYS9
187451 M05B5.2 Protein M05B5.2 Caenorhabditis elegans Pro-Longevity 45% Decrease M05B5.2
177113 M57.2 Protein M57.2 Caenorhabditis elegans Pro-Longevity 20% Decrease M57.2
33529 Mad Mothers against dpp Drosophila melanogaster Pro-Longevity 22% Decrease Mad
853422 MAD2 Mitotic Arrest-Deficient Saccharomyces cerevisiae Anti-Longevity 50% Increase MAD2
173073 mag-1 Drosophila MAGonashi homolog Caenorhabditis elegans Pro-Longevity 15% Decrease mag-1
36048 magu magu gene product from transcript magu -RD Drosophila melanogaster Pro-Longevity 5% Increase magu
856657 MAK10 MAintenance of Killer Saccharomyces cerevisiae Necessary For Fitness Decrease MAK10
856163 MAK3 MAintenance of Killer Saccharomyces cerevisiae Necessary For Fitness Decrease MAK3
852600 MAL33 MALtose fermentation Saccharomyces cerevisiae Necessary For Fitness Decrease MAL33
174181 maoc-1 MAO-C-like dehydratase domain Caenorhabditis elegans Anti-Longevity Increase maoc-1
178089 mars-1 Methionyl tRNA Synthetase Caenorhabditis elegans Anti-Longevity 23% Increase mars-1
179794 max-1 Motor AXon guidance Caenorhabditis elegans Anti-Longevity Increase max-1
3565400 max-2 Motor AXon guidance Caenorhabditis elegans Anti-Longevity 25% Increase max-2
852483 MBA1 Multi-copy Bypass of AFG3 Saccharomyces cerevisiae Anti-Longevity Increase and Decrease MBA1
181681 mboa-1 Protein MBOA-1 Caenorhabditis elegans Pro-Longevity 16% Decrease mboa-1
854372 MCA1 Ca(2+)-dependent cysteine protease MCA1 Saccharomyces cerevisiae Pro-Longevity 56% Increase MCA1
854483 MCH5 MonoCarboxylate transporter Homologue Saccharomyces cerevisiae Necessary For Fitness Decrease MCH5
174841 mcm-2 yeast MCM (licensing factor) related Caenorhabditis elegans Unclear Increase and Decrease mcm-2
17216 Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) Mus musculus Pro-Longevity Decrease Mcm2
179041 mdh-1 Malate DeHydrogenase Caenorhabditis elegans Anti-Longevity 4% Increase mdh-1
175936 mdh-2 Malate DeHydrogenase Caenorhabditis elegans Pro-Longevity 10% Decrease mdh-2
853777 MDH1 Malate DeHydrogenase Saccharomyces cerevisiae Pro-Longevity 25% Increase MDH1
853994 MDH2 Malate DeHydrogenase Saccharomyces cerevisiae Pro-Longevity 15% Increase MDH2
180942 mdl-1 MAD-Like Caenorhabditis elegans Anti-Longevity 16% Increase mdl-1
854079 MDM20 Mitochondrial Distribution and Morphology Saccharomyces cerevisiae Necessary For Fitness Decrease MDM20
175817 mdt-15 Mediator of RNA polymerase II transcription subunit 15 Caenorhabditis elegans Pro-Longevity 34% Decrease mdt-15
173960 mdt-26 Protein MDT-26 Caenorhabditis elegans Pro-Longevity Decrease mdt-26
172771 mec-8 MEChanosensory abnormality Caenorhabditis elegans Unannotated Increase mec-8
852433 MEC1 Mec1p Saccharomyces cerevisiae Necessary For Fitness 66% Decrease MEC1
174963 mecr-1 Protein MECR-1 Caenorhabditis elegans Anti-Longevity Increase mecr-1
856183 MED1 MEDiator complex Saccharomyces cerevisiae Necessary For Fitness Decrease MED1
171872 mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 Caenorhabditis elegans Pro-Longevity 10% Decrease mek-2
175634 mel-28 Protein MEL-28 Caenorhabditis elegans Anti-Longevity 6% Increase mel-28
179163 memo-1 MEdiator of cell MOtility 1 homolog Caenorhabditis elegans Anti-Longevity 38% Increase memo-1
47173 Men Malic enzyme Drosophila melanogaster Pro-Longevity 45% Increase Men
178074 mep-1 Mog interacting, Ectopic P granules Caenorhabditis elegans Pro-Longevity 8% Decrease mep-1
855580 MEP2 Mep2p Saccharomyces cerevisiae Anti-Longevity Increase MEP2
856260 MEP3 Mep3p Saccharomyces cerevisiae Anti-Longevity Increase MEP3
181362 mes-1 Maternal Effect Sterile Caenorhabditis elegans Anti-Longevity 60% Increase mes-1
175096 mes-2 Histone-lysine N-methyltransferase mes-2 Caenorhabditis elegans Anti-Longevity 6% Increase mes-2
176183 met-2 Histone-lysine N-methyltransferase met-2 Caenorhabditis elegans Pro-Longevity 23% Decrease met-2
853869 MET14 adenylyl-sulfate kinase Saccharomyces cerevisiae Anti-Longevity Increase MET14
856296 MET16 phosphoadenylyl-sulfate reductase (thioredoxin) Saccharomyces cerevisiae Anti-Longevity Increase MET16
851010 MET17 bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Saccharomyces cerevisiae Anti-Longevity 100% Increase MET17
855444 MET2 METhionine requiring Saccharomyces cerevisiae Anti-Longevity Increase and Decrease MET2
853602 MET5 sulfite reductase (NADPH) subunit beta Saccharomyces cerevisiae Necessary For Fitness Decrease MET5
856825 MET6 METhionine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease MET6
260040 mev-1 Abnormal MEthyl Viologen sensitivity Caenorhabditis elegans Pro-Longevity Decrease mev-1
174752 mfn-1 Protein MFN-1 Caenorhabditis elegans Anti-Longevity 64% Increase mfn-1
107895 Mgat5 mannoside acetylglucosaminyltransferase 5 Mus musculus Pro-Longevity Decrease Mgat5
853408 MHP1 MAP-Homologous Protein Saccharomyces cerevisiae Necessary For Fitness Decrease MHP1
179475 mics-1 MItoChondrial Scaffolding protei Caenorhabditis elegans Anti-Longevity 54% Increase mics-1
17319 Mif macrophage migration inhibitory factor Mus musculus Anti-Longevity 16% Increase Mif
852848 MIG1 transcription factor MIG1 Saccharomyces cerevisiae Anti-Longevity Decrease MIG1
3565990 mir-124 mir-124 Caenorhabditis elegans Pro-Longevity 16% Increase mir-124
12798013 mir-125 mir-125 stem loop Drosophila melanogaster Pro-Longevity Decrease mir-125
12798384 mir-14 mir-14 stem loop Drosophila melanogaster Pro-Longevity Decrease mir-14
12798434 mir-184 mir-184 stem loop Drosophila melanogaster Anti-Longevity Decrease mir-184
3564977 mir-238 mir-238 Caenorhabditis elegans Anti-Longevity 20% Increase mir-238
3565806 mir-238 mir-238 Caenorhabditis elegans Pro-Longevity 19% Decrease mir-238
3565660 mir-246 mir-246 Caenorhabditis elegans Pro-Longevity 10% Decrease mir-246
12798086 mir-277 mir-277 stem loop Drosophila melanogaster Anti-Longevity 70% Increase mir-277
260162 mir-34 mir-34 Caenorhabditis elegans Anti-Longevity 62% Increase mir-34
12798087 mir-34 mir-34 stem loop Drosophila melanogaster Pro-Longevity Decrease mir-34
260100 mir-71 mir-71 Caenorhabditis elegans Pro-Longevity 48% Decrease mir-71
3565575 mir-80 microRNA-80 Caenorhabditis elegans Anti-Longevity Increase mir-80
853540 MIR1 Mir1p Saccharomyces cerevisiae Anti-Longevity 25% Increase MIR1
723905 Mir17 microRNA 17 Mus musculus Pro-Longevity 16% Increase Mir17
387222 Mir29a microRNA 29a Mus musculus Unannotated Mir29a
177238 miro-1 Mitochondrial Rho GTPase 1 Caenorhabditis elegans Anti-Longevity 50% Increase miro-1
852378 MIS1 MItochondrial C1-tetrahydrofolate Synthase Saccharomyces cerevisiae Necessary For Fitness Decrease MIS1
185682 mkk-4 MKK (MAP Kinase Kinase) homolog Caenorhabditis elegans Anti-Longevity Decrease mkk-4
854406 MKK1 Mitogen-activated protein Kinase-Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease MKK1
855648 MKS1 Multicopy Kinase Suppressor Saccharomyces cerevisiae Anti-Longevity Increase and Decrease MKS1
35523 mle Maleless Drosophila melanogaster Pro-Longevity 48% Decrease mle
40849 Mlp84B Muscle LIM protein at 84B Drosophila melanogaster Pro-Longevity 35% Decrease Mlp84B
176050 mml-1 Myc and Mondo-Like Caenorhabditis elegans Pro-Longevity 10% Decrease mml-1
854532 MNE1 Mne1p Saccharomyces cerevisiae Necessary For Fitness Decrease MNE1
174623 mnk-1 MAP kinase iNtegrating Kinase (MNK) homolog Caenorhabditis elegans Pro-Longevity Decrease mnk-1
856718 MNN1 alpha-1,3-mannosyltransferase MNN1 Saccharomyces cerevisiae Anti-Longevity 15% Increase MNN1
852303 MNN2 alpha-1,2-mannosyltransferase MNN2 Saccharomyces cerevisiae Anti-Longevity 16% Increase MNN2
853595 MNS1 Mns1p Saccharomyces cerevisiae Anti-Longevity Increase MNS1
31331 Mnt CG13316-PC, isoform C Drosophila melanogaster Pro-Longevity Increase and Decrease Mnt
2543646 moc3 transcription factor Moc3 Schizosaccharomyces pombe Anti-Longevity Increase moc3
171879 mod-5 Modulation Of locomotion Defective Caenorhabditis elegans Pro-Longevity Decrease mod-5
852231 MOH1 Moh1p Saccharomyces cerevisiae Necessary For Fitness Decrease MOH1
855420 MON2 MONensin sensitivity Saccharomyces cerevisiae Necessary For Fitness Decrease MON2
852800 MPC1 Mpc1p Saccharomyces cerevisiae Necessary For Fitness Decrease MPC1
854462 MPD1 protein disulfide isomerase MPD1 Saccharomyces cerevisiae Anti-Longevity 17% Increase MPD1
175545 mpk-1 MAP Kinase Caenorhabditis elegans Pro-Longevity 16% Decrease mpk-1
42866 Mpk2 CG5475-PA Drosophila melanogaster Pro-Longevity 40% Decrease Mpk2
852697 MPT5 Mpt5p Saccharomyces cerevisiae Pro-Longevity Increase and Decrease MPT5
174657 mpz-1 Multiple PDZ domain protein Caenorhabditis elegans Anti-Longevity 31% Increase mpz-1
177736 mpz-2 Temporarily Assigned Gene name Caenorhabditis elegans Anti-Longevity Increase mpz-2
2543240 mrc1 mrc1 Schizosaccharomyces pombe Anti-Longevity Increase mrc1
855264 MRE11 Meiotic REcombination Saccharomyces cerevisiae Necessary For Fitness 50% Decrease MRE11
852816 MRH4 Mitochondrial RNA Helicase Saccharomyces cerevisiae Necessary For Fitness Decrease MRH4
181587 mrp-5 Multidrug Resistance Protein family Caenorhabditis elegans Anti-Longevity Increase mrp-5
851948 MRP1 Mitochondrial Ribosomal Protein Saccharomyces cerevisiae Necessary For Fitness Decrease MRP1
856295 MRP2 Mitochondrial Ribosomal Protein Saccharomyces cerevisiae Necessary For Fitness Decrease MRP2
41387 Mrp4 Multidrug resistance protein 4 ortholog Drosophila melanogaster Pro-Longevity Increase and Decrease Mrp4
855985 MRP51 Mitochondrial Ribosomal Protein Saccharomyces cerevisiae Necessary For Fitness Decrease MRP51
186840 mrpl-10 Protein MRPL-10 Caenorhabditis elegans Anti-Longevity 17% Increase mrpl-10
176495 mrpl-12 Protein MRPL-12 Caenorhabditis elegans Anti-Longevity 51% Increase mrpl-12
176903 mrpl-2 Protein MRPL-2 Caenorhabditis elegans Anti-Longevity 54% Increase mrpl-2
172204 mrpl-24 Protein MRPL-24 Caenorhabditis elegans Anti-Longevity 14% Increase mrpl-24
175001 mrpl-37 Protein MRPL-37 Caenorhabditis elegans Anti-Longevity 41% Increase mrpl-37
172164 mrpl-47 Protein MRPL-47 Caenorhabditis elegans Anti-Longevity 20% Increase mrpl-47
174422 mrpl-50 Protein MRPL-50 Caenorhabditis elegans Anti-Longevity 17% Increase mrpl-50
851325 MRPL11 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL11
855469 MRPL17 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL17
853960 MRPL20 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL20
855544 MRPL22 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL22
855231 MRPL24 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL24
850359 MRPL32 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL32
855330 MRPL33 mitochondrial 54S ribosomal protein YmL33 Saccharomyces cerevisiae Anti-Longevity 16% Increase MRPL33
853684 MRPL38 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL38
855002 MRPL39 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness 20% Decrease MRPL39
851160 MRPL4 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Anti-Longevity Increase and Decrease MRPL4
855930 MRPL40 mitochondrial 54S ribosomal protein YmL40 Saccharomyces cerevisiae Anti-Longevity 21% Increase MRPL40
853349 MRPL49 mitochondrial 54S ribosomal protein YmL49 Saccharomyces cerevisiae Anti-Longevity 25% Increase MRPL49
853135 MRPL9 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL9
189618 mrps-10 Protein MRPS-10 Caenorhabditis elegans Anti-Longevity 39% Increase mrps-10
172957 mrps-30 Temporarily Assigned Gene name Caenorhabditis elegans Anti-Longevity 21% Increase mrps-30
184770 mrps-33 Protein MRPS-33 Caenorhabditis elegans Anti-Longevity 36% Increase mrps-33
179721 mrps-5 Protein MRPS-5 Caenorhabditis elegans Anti-Longevity 60% Increase mrps-5
184267 mrps-9 Protein MRPS-9 Caenorhabditis elegans Anti-Longevity 60% Increase mrps-9
856094 MRPS16 Mitochondrial Ribosomal Protein, Small subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPS16
854511 MRS2 Mitochondrial RNA Splicing Saccharomyces cerevisiae Necessary For Fitness Decrease MRS2
853926 MRS4 Mitochondrial RNA Splicing Saccharomyces cerevisiae Necessary For Fitness 40% Decrease MRS4
853860 MRT4 mRNA Turnover 4 Saccharomyces cerevisiae Necessary For Fitness 50% Decrease MRT4
851692 MRX14 putative mitochondrial 54S ribosomal protein Saccharomyces cerevisiae Anti-Longevity 12% Increase MRX14
17685 Msh2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) Mus musculus Pro-Longevity Decrease Msh2
854063 MSH2 MutS Homolog Saccharomyces cerevisiae Necessary For Fitness 50% Decrease MSH2
2543392 msh3 MutS protein homolog 3 Schizosaccharomyces pombe Anti-Longevity Increase msh3
851671 MSH6 MutS Homolog Saccharomyces cerevisiae Necessary For Fitness 50% Decrease MSH6
855651 MSK1 lysine--tRNA ligase MSK1 Saccharomyces cerevisiae Anti-Longevity 12% Increase MSK1
110265 Msra Methionine sulfoxide reductase A Mus musculus Pro-Longevity Decrease Msra
851775 MSS116 Mitochondrial Splicing System Saccharomyces cerevisiae Necessary For Fitness Decrease MSS116
856253 MSS18 Mitochondrial Splicing System Saccharomyces cerevisiae Necessary For Fitness Decrease MSS18
17700 Mstn myostatin Mus musculus Anti-Longevity 15% Increase Mstn
851861 MSW1 Mitochondrial aminoacyl-tRNA Synthetase, tryptophan (W) Saccharomyces cerevisiae Anti-Longevity Increase and Decrease MSW1
17748 Mt1 metallothionein 1 Mus musculus Pro-Longevity 14% Increase Mt1
34632 Mt2 DNA methyltransferase 2 Drosophila melanogaster Pro-Longevity Increase Mt2
105837 Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein Mus musculus Anti-Longevity 20% Increase Mtbp
853319 MTC1 Maintenance of Telomere Capping Saccharomyces cerevisiae Necessary For Fitness Decrease MTC1
852557 MTC4 Mtc4p Saccharomyces cerevisiae Anti-Longevity Increase and Decrease MTC4
851706 MTC5 Maintenance of Telomere Capping Saccharomyces cerevisiae Necessary For Fitness 35% Decrease MTC5
856678 MTC7 Maintenance of Telomere Capping Saccharomyces cerevisiae Necessary For Fitness Decrease MTC7
174207 mtch-1 Protein MTCH-1 Caenorhabditis elegans Anti-Longevity 21% Increase mtch-1
853955 MTD1 Methylene Tetrahydrafolate Dehydrogenase Saccharomyces cerevisiae Anti-Longevity Increase MTD1
39089 MTF-1 Metal response element-binding Transcription Factor-1 Drosophila melanogaster Pro-Longevity 40% Increase MTF-1
38058 mth methuselah Drosophila melanogaster Unclear 35% Increase mth
179899 mtl-2 MeTaLlothionein Caenorhabditis elegans Anti-Longevity Increase mtl-2
175490 mtm-3 MTM (myotubularin) famil Caenorhabditis elegans Pro-Longevity Decrease mtm-3
853173 MTM1 Manganese Trafficking factor for Mitochondrial SOD2 Saccharomyces cerevisiae Anti-Longevity Increase and Decrease MTM1
852616 MTO1 Mitochondrial Translation Optimization Saccharomyces cerevisiae Necessary For Fitness Decrease MTO1
56717 Mtor mechanistic target of rapamycin (serine/threonine kinase) Mus musculus Anti-Longevity 20% Increase Mtor
40436 mub mushroom-body expressed Drosophila melanogaster Anti-Longevity 21% Increase mub
855126 MUB1 Mub1p Saccharomyces cerevisiae Anti-Longevity 29% Increase MUB1
2540673 mug80 cyclin Clg1 (predicted) Schizosaccharomyces pombe Anti-Longevity Increase mug80
852348 MUM2 MUddled Meiosis Saccharomyces cerevisiae Anti-Longevity Increase MUM2
175863 mvk-1 Y42G9A.4b Caenorhabditis elegans Pro-Longevity 14% Decrease mvk-1
175184 mxl-2 MaX-Like Caenorhabditis elegans Pro-Longevity 7% Decrease mxl-2
856765 MXR1 Mxr1p Saccharomyces cerevisiae Pro-Longevity Increase and Decrease MXR1
17869 Myc myelocytomatosis oncogene Mus musculus Anti-Longevity 21% Increase Myc
43811 myo myoglianin Drosophila melanogaster Pro-Longevity 25% Increase myo
44885 mys myospheroid Drosophila melanogaster Anti-Longevity 44% Increase mys
42348 Naam Naam gene product from transcript Naam-RA Drosophila melanogaster Pro-Longevity 30% Increase Naam
187898 nac-2 NADC (Na+-coupled dicarboxylate transporter) family Caenorhabditis elegans Anti-Longevity 19% Increase nac-2
176429 nac-3 NADC (Na+-coupled dicarboxylate transporter) family Caenorhabditis elegans Anti-Longevity 15% Increase nac-3
851098 NAM2 Nuclear Accommodation of Mitochondria Saccharomyces cerevisiae Necessary For Fitness Decrease NAM2
172442 nars-1 asparagiNyl tRNA Synthetase Caenorhabditis elegans Anti-Longevity 11% Increase nars-1
180407 nas-38 Nematode AStacin protease Caenorhabditis elegans Anti-Longevity Increase nas-38
855091 NAT4 Nat4p Saccharomyces cerevisiae Anti-Longevity 21% Increase NAT4
184953 ncbp-2 Nuclear Cap-Binding Protein Caenorhabditis elegans Pro-Longevity 24% Decrease ncbp-2
20602 Ncor2 nuclear receptor co-repressor 2 Mus musculus Pro-Longevity 50% Decrease Ncor2
856101 NCR1 Niemann-pick type C Related Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NCR1
2542523 ncs1 neuronal calcium sensor related protein Schizosaccharomyces pombe Anti-Longevity Increase ncs1
31762 ND75 NADH:ubiquinone reductase 75kD subunit precursor Drosophila melanogaster Anti-Longevity 15% Increase ND75
855176 NDE1 NADH-ubiquinone reductase (H(+)-translocating) NDE1 Saccharomyces cerevisiae Unclear 25% Increase NDE1
851474 NDE2 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae Pro-Longevity 25% Increase NDE2
175582 ndg-4 hypothetical protein Caenorhabditis elegans Anti-Longevity 71% Increase ndg-4
854919 NDI1 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae Unclear Increase and Decrease NDI1
172939 ndk-1 Nucleoside diphosphate kinase Caenorhabditis elegans Anti-Longevity Increase ndk-1
2543111 ndk1 nucleoside diphosphate kinase Ndk1 Schizosaccharomyces pombe Anti-Longevity Increase ndk1
856524 NDT80 Ndt80p Saccharomyces cerevisiae Pro-Longevity Increase NDT80
188912 nduf-2.2 NADH Ubiquinone oxidoreductase Fe-S protein Caenorhabditis elegans Anti-Longevity 20% Increase nduf-2.2
72774 Neil1 nei endonuclease VIII-like 1 (E. coli) Mus musculus Pro-Longevity Decrease Neil1
855875 NEW1 New1p Saccharomyces cerevisiae Unannotated NEW1
43149 Nf1 Neurofibromin 1 Drosophila melanogaster Pro-Longevity 68% Increase Nf1
174225 nfi-1 NFI (Nuclear Factor I) family Caenorhabditis elegans Pro-Longevity Decrease nfi-1
18033 Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus Pro-Longevity 33% Decrease Nfkb1
853826 NFU1 NifU-like protein Saccharomyces cerevisiae Necessary For Fitness Decrease NFU1
187340 nhr-119 Protein NHR-119 Caenorhabditis elegans Pro-Longevity 10% Decrease nhr-119
181102 nhr-14 Nuclear Hormone Receptor family Caenorhabditis elegans Anti-Longevity Increase nhr-14
182565 nhr-154 Nuclear Hormone Receptor family Caenorhabditis elegans Anti-Longevity Increase nhr-154
172460 nhr-23 Protein NHR-23 Caenorhabditis elegans Anti-Longevity 5% Increase nhr-23
181432 nhr-25 Protein NHR-25 Caenorhabditis elegans Pro-Longevity 8% Decrease nhr-25
185603 nhr-265 Protein NHR-265 Caenorhabditis elegans Anti-Longevity 4% Increase nhr-265
172839 nhr-49 Nuclear Hormone Receptor family Caenorhabditis elegans Pro-Longevity 56% Decrease nhr-49
191726 nhr-77 Protein NHR-77 Caenorhabditis elegans Pro-Longevity 7% Decrease nhr-77
177551 nhr-8 Nuclear hormone receptor family member nhr-8 Caenorhabditis elegans Pro-Longevity 35% Decrease nhr-8
174242 nhx-2 Na/H eXchanger Caenorhabditis elegans Anti-Longevity 40% Increase nhx-2
855929 NIP100 Nuclear ImPort Saccharomyces cerevisiae Necessary For Fitness Decrease NIP100
3565648 nkcc-1 Protein NKCC-1 Caenorhabditis elegans Anti-Longevity 23% Increase nkcc-1
33324 NLaz Neural Lazarillo Drosophila melanogaster Pro-Longevity 31% Decrease NLaz
184647 nlp-7 Neuropeptide-like protein genes family Caenorhabditis elegans Pro-Longevity 10% Decrease nlp-7
855600 NMA111 Nuclear Mediator of Apoptosis Saccharomyces cerevisiae Pro-Longevity Increase NMA111
856476 NMD2 Nonsense-mediated MRNA Decay Saccharomyces cerevisiae Necessary For Fitness Decrease NMD2
851077 NMD4 Nonsense-Mediated mRNA Decay Saccharomyces cerevisiae Anti-Longevity Increase and Decrease NMD4
47895 Nmdmc NAD-dependent methylenetetrahydrofolate dehydrogenase Drosophila melanogaster Pro-Longevity 120% Increase Nmdmc
850892 NMT1 N-Myristoyl Transferase Saccharomyces cerevisiae Anti-Longevity 50% Increase NMT1
853683 NNK1 Nitrogen Network Kinase Saccharomyces cerevisiae Anti-Longevity Increase NNK1
180884 nnt-1 Nicotinamide Nucleotide Transhydrogenase Caenorhabditis elegans Pro-Longevity 18% Decrease nnt-1
173437 nol-1 NucleOLar protein Caenorhabditis elegans Anti-Longevity 31% Increase nol-1
171901 nol-5 NucleOLar protein Caenorhabditis elegans Anti-Longevity 15% Increase nol-5
18127 Nos3 nitric oxide synthase 3, endothelial cell Mus musculus Pro-Longevity Decrease Nos3
179095 npa-1 Nematode Polyprotein Allergen related Caenorhabditis elegans Anti-Longevity 32% Increase npa-1
42018 NPF neuropeptide F Drosophila melanogaster Anti-Longevity 25% Decrease NPF
852042 NPL3 Nuclear Protein Localization Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NPL3
172611 npp-2 Nuclear Pore complex Protein Caenorhabditis elegans Pro-Longevity 11% Decrease npp-2
174823 npp-3 Nuclear Pore complex Protein Caenorhabditis elegans Pro-Longevity 14% Decrease npp-3
180752 npr-1 NeuroPeptide Receptor family Caenorhabditis elegans Anti-Longevity 16% Increase npr-1
854384 NPT1 Nicotinatephosphoribosyltranfserase Saccharomyces cerevisiae Pro-Longevity Increase and Decrease NPT1
855594 NRK1 Nicotinamide Riboside Kinase Saccharomyces cerevisiae Necessary For Fitness 20% Decrease NRK1
179503 nrx-1 GLIoTactin (Drosophila neuroligin-like) homolog Caenorhabditis elegans Anti-Longevity Decrease nrx-1
853064 NSR1 Nsr1p Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NSR1
855633 NST1 Negatively affects Salt Tolerance Saccharomyces cerevisiae Anti-Longevity Increase and Decrease NST1
191128 nstp-3 Protein NSTP-3 Caenorhabditis elegans Pro-Longevity 29% Decrease nstp-3
175153 nsun-5 Nop2 (NOP2)/SUN domain family member Caenorhabditis elegans Anti-Longevity 17% Increase nsun-5
851564 NTH1 Neutral TreHalase Saccharomyces cerevisiae Necessary For Fitness 15% Decrease NTH1
176614 ntl-3 NOT-Like (yeast CCR4/NOT complex component) Caenorhabditis elegans Pro-Longevity Decrease ntl-3
181174 nuc-1 abnormal NUClease Caenorhabditis elegans Anti-Longevity Increase nuc-1
4521 NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 Mus musculus Pro-Longevity 16% Increase NUDT1
176048 numr-1 NUclear localized Metal Responsive Caenorhabditis elegans Pro-Longevity Increase numr-1
176049 numr-2 NUclear localized Metal Responsive Caenorhabditis elegans Pro-Longevity Increase numr-2
174696 nuo-1 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity 50% Increase nuo-1
172363 nuo-2 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity Increase nuo-2
178404 nuo-3 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity 77% Increase nuo-3
176001 nuo-4 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity 38% Increase nuo-4
178735 nuo-5 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity Increase nuo-5
172438 nuo-6 Protein NUO-6 Caenorhabditis elegans Anti-Longevity 73% Increase nuo-6
852199 NUP170 NUclear Pore Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NUP170
850782 NYV1 New Yeast V-SNARE Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NYV1
188314 ocr-2 Osm-9 and Capsaicin receptor-Related Caenorhabditis elegans Anti-Longevity Increase ocr-2
179098 odr-2 hypothetical protein Caenorhabditis elegans Anti-Longevity 25% Increase odr-2
179806 odr-3 ODoRant response abnormal Caenorhabditis elegans Anti-Longevity 30% Increase odr-3
181403 odr-7 Nuclear hormone receptor family member odr-7 Caenorhabditis elegans Anti-Longevity 27% Increase odr-7
177235 ogdh-1 Protein OGDH-1 Caenorhabditis elegans Anti-Longevity 79% Increase ogdh-1
191737 old-1 Overexpression Longevity Determinant Caenorhabditis elegans Pro-Longevity 65% Increase old-1
854670 OM45 Outer Membrane Saccharomyces cerevisiae Anti-Longevity Increase OM45
853962 OMA1 Overlapping activity with M-AAA protease Saccharomyces cerevisiae Necessary For Fitness 70% Decrease OMA1
853536 OPI3 OverProducer of Inositol Saccharomyces cerevisiae Necessary For Fitness Decrease OPI3
856324 OPT2 OligoPeptide Transporter 2 Saccharomyces cerevisiae Anti-Longevity 23% Increase OPT2
40650 Orco Odorant receptor co-receptor Drosophila melanogaster Anti-Longevity 56% Increase Orco
851543 OSH2 OxySterol binding protein Homolog Saccharomyces cerevisiae Necessary For Fitness Decrease OSH2
853872 OSH6 oxysterol-binding protein OSH6 Saccharomyces cerevisiae Pro-Longevity 23% Increase OSH6
181715 osm-1 OSMotic avoidance abnormal Caenorhabditis elegans Anti-Longevity 40% Increase osm-1
177141 osm-3 OSMotic avoidance abnormal Caenorhabditis elegans Anti-Longevity Increase osm-3
180585 osm-5 OSMotic avoidance abnormal Caenorhabditis elegans Anti-Longevity 150% Increase osm-5
179631 osm-6 OSMotic avoidance abnormal Caenorhabditis elegans Anti-Longevity 40% Increase osm-6
854252 OST3 dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 Saccharomyces cerevisiae Anti-Longevity 20% Increase OST3
5009 OTC ornithine carbamoyltransferase Drosophila melanogaster Pro-Longevity 21% Increase OTC
31429 ovo CG6824-PA Drosophila melanogaster Anti-Longevity 50% Increase ovo
34780 p38b CG7393-PA Drosophila melanogaster Pro-Longevity 60% Decrease p38b
2768677 p53 CG33336-PA Drosophila melanogaster Anti-Longevity 58% Increase p53
851643 PAA1 PolyAmine Acetyltransferase Saccharomyces cerevisiae Necessary For Fitness Decrease PAA1
172920 pab-1 PolyA Binding protein Caenorhabditis elegans Anti-Longevity 30% Increase pab-1
181473 pab-2 PolyA Binding protein Caenorhabditis elegans Anti-Longevity Increase pab-2
852969 PAC10 Protein required in the Absence of Cin8p Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PAC10
180873 pak-1 Serine/threonine-protein kinase pak-1 Caenorhabditis elegans Unannotated 50% Increase pak-1
18491 Pappa Pregnancy-associated plasma protein A Mus musculus Anti-Longevity 30% Increase Pappa
178113 par-5 abnormal embryonic PARtitioning of cytoplasm Caenorhabditis elegans Pro-Longevity Increase and Decrease par-5
2539379 par1 protein phosphatase regulatory subunit Par1 Schizosaccharomyces pombe Anti-Longevity Increase par1
40336 park parkin Drosophila melanogaster Pro-Longevity 28% Increase park
11545 Parp1 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) Mus musculus Unannotated 25% Decrease Parp1
172950 pash-1 PArtner of DroSHa (DRSH-1 interactor) Caenorhabditis elegans Pro-Longevity 31% Decrease pash-1
172127 pat-10 Paralysed Arrest at Two-fold Caenorhabditis elegans Pro-Longevity 30% Increase pat-10
175504 pat-3 Protein PAT-3 Caenorhabditis elegans Pro-Longevity 28% Decrease pat-3
175175 pat-4 Paralysed Arrest at Two-fold Caenorhabditis elegans Anti-Longevity 24% Increase pat-4
176848 pat-6 Paralysed Arrest at Two-fold Caenorhabditis elegans Anti-Longevity 60% Increase pat-6
856662 PAU2 seriPAUperin family Saccharomyces cerevisiae Necessary For Fitness Decrease PAU2
114774 Pawr PRKC, apoptosis, WT1, regulator Mus musculus Pro-Longevity Increase and Decrease Pawr
173334 pbs-5 Proteasome subunit beta type Caenorhabditis elegans Pro-Longevity 25% Increase pbs-5
852598 PCA1 P-type Cation-transporting ATPase Saccharomyces cerevisiae Necessary For Fitness Decrease PCA1
246008 pcf-11 Protein PCF-11 Caenorhabditis elegans Pro-Longevity 19% Decrease pcf-11
174313 pch-2 Putative pachytene checkpoint protein 2 Caenorhabditis elegans Pro-Longevity 22% Increase pch-2
852484 PCH2 Pachytene CHeckpoint Saccharomyces cerevisiae Anti-Longevity 50% Increase PCH2
172556 pck-2 R11A5.4b Caenorhabditis elegans Anti-Longevity Increase pck-2
18534 Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus Pro-Longevity Increase Pck1
853972 PCK1 Phosphoenolpyruvate CarboxyKinase Saccharomyces cerevisiae Necessary For Fitness Decrease PCK1
856787 PCL6 Pho85 CycLin Saccharomyces cerevisiae Necessary For Fitness Decrease PCL6
854761 PCL7 Pho85 CycLin Saccharomyces cerevisiae Anti-Longevity Increase PCL7
178981 pcm-1 Protein Carboxymethyltransferase Caenorhabditis elegans Pro-Longevity 30% Increase pcm-1
40668 Pcmt Protein-L-isoaspartate (D-aspartate) O-methyltransferase Drosophila melanogaster Pro-Longevity 39% Increase Pcmt
852993 PCP1 Processing of Cytochrome c Peroxidase Saccharomyces cerevisiae Necessary For Fitness Decrease PCP1
856925 PDA1 Pyruvate Dehydrogenase Alpha Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PDA1
850733 PDC1 Pyruvate DeCarboxylase Saccharomyces cerevisiae Necessary For Fitness Decrease PDC1
854542 PDE2 PhosphoDiEsterase Saccharomyces cerevisiae Necessary For Fitness Decrease PDE2
180475 pdk-1 PDK-class protein kinase Caenorhabditis elegans Anti-Longevity 60% Increase pdk-1
172035 pdp-1 Pyruvate Dehydrogenase Phosphatase homolog Caenorhabditis elegans Pro-Longevity 17% Increase pdp-1
855807 PDR18 Pleiotropic Drug Resistance Saccharomyces cerevisiae Anti-Longevity Increase PDR18
852323 PDX3 PyriDoXine auxotrophy Saccharomyces cerevisiae Anti-Longevity 50% Increase PDX3
2539366 pef1 Pho85/PhoA-like cyclin-dependent kinase Pef1 Schizosaccharomyces pombe Anti-Longevity Increase pef1
854201 PEP12 carboxyPEPtidase Y-deficient Saccharomyces cerevisiae Necessary For Fitness 25% Decrease PEP12
2542423 pep7 prevacuole/endosomal FYVE tethering component Pep7 (predicted) Schizosaccharomyces pombe Necessary For Fitness Decrease pep7
180919 pept-1 OligoPeptide Transporter Caenorhabditis elegans Anti-Longevity 40% Increase pept-1
18627 Per2 period circadian clock 2 Mus musculus Anti-Longevity Increase Per2
173025 pes-2.1 Patterned Expression Site Caenorhabditis elegans Anti-Longevity Increase pes-2.1
855299 PET111 PETite colonies Saccharomyces cerevisiae Necessary For Fitness Decrease PET111
852198 PET112 PETite colonies Saccharomyces cerevisiae Necessary For Fitness Decrease PET112
856786 PET117 PETite colonies Saccharomyces cerevisiae Necessary For Fitness Decrease PET117
854182 PET127 Pet127p Saccharomyces cerevisiae Anti-Longevity 35% Increase PET127
850756 PET309 Pet309p Saccharomyces cerevisiae Anti-Longevity 25% Increase PET309
852250 PET9 PETite colonies Saccharomyces cerevisiae Pro-Longevity 30% Decrease PET9
852724 PEX14 PEroXisome related Saccharomyces cerevisiae Necessary For Fitness Decrease PEX14
40293 Pex16 peroxin 16 Drosophila melanogaster Pro-Longevity 75% Decrease Pex16
853219 PEX2 PEroXin Saccharomyces cerevisiae Necessary For Fitness Decrease PEX2
855991 PEX25 PEroXisome related Saccharomyces cerevisiae Anti-Longevity Increase PEX25
851831 PEX5 PEroXin Saccharomyces cerevisiae Necessary For Fitness Decrease PEX5
855387 PEX6 PEroXin Saccharomyces cerevisiae Necessary For Fitness Decrease PEX6
855390 PFA3 Protein Fatty Acyltransferase Saccharomyces cerevisiae Necessary For Fitness 25% Decrease PFA3
852070 PFA5 Protein Fatty Acyltransferase Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PFA5
180808 pfn-2 ProFiliN Caenorhabditis elegans Anti-Longevity Increase pfn-2
854914 PGA3 Processing of Gas1p and ALP Saccharomyces cerevisiae Pro-Longevity 30% Increase PGA3
31143 Pgam5 Phosphoglycerate mutase 5 Drosophila melanogaster Pro-Longevity 9% Decrease Pgam5
171746 pghm-1 Protein PGHM-1 Caenorhabditis elegans Anti-Longevity Increase pghm-1
177461 pgl-1 P GranuLe abnormality Caenorhabditis elegans Anti-Longevity Increase pgl-1
180357 pha-4 defective PHArynx development Caenorhabditis elegans Pro-Longevity 13% Decrease pha-4
171768 phb-1 mitochondrial ProHiBitin complex Caenorhabditis elegans Pro-Longevity Decrease phb-1
174034 phb-2 mitochondrial ProHiBitin complex Caenorhabditis elegans Pro-Longevity Decrease phb-2
853033 PHB1 Phb1p Saccharomyces cerevisiae Pro-Longevity 20% Decrease PHB1
853146 PHB2 Phb2p Saccharomyces cerevisiae Pro-Longevity 30% Decrease PHB2
853823 PHD1 PseudoHyphal Determinant Saccharomyces cerevisiae Anti-Longevity 20% Increase PHD1
851452 PHO2 PHOsphate metabolism Saccharomyces cerevisiae Necessary For Fitness 25% Decrease PHO2
855626 PHO23 PHOsphate metabolism Saccharomyces cerevisiae Necessary For Fitness Decrease PHO23
854916 PHO84 phosphate transporter PHO84 Saccharomyces cerevisiae Pro-Longevity 14% Increase PHO84
856076 PHO85 PHOsphate metabolism Saccharomyces cerevisiae Necessary For Fitness 45% Decrease PHO85
852599 PHO89 PHOsphate metabolism Saccharomyces cerevisiae Anti-Longevity 50% Increase PHO89
2541161 php2 CCAAT-binding factor complex subunit Php2 Schizosaccharomyces pombe Anti-Longevity Increase php2
42446 Pi3K92E CG4141 gene product from transcript CG4141-RA Drosophila melanogaster Pro-Longevity 5% Decrease Pi3K92E
851908 PIB1 PhosphatidylInositol(3)-phosphate Binding Saccharomyces cerevisiae Anti-Longevity 25% Increase PIB1
852259 PIM1 Proteolysis In Mitochondria Saccharomyces cerevisiae Necessary For Fitness 50% Decrease PIM1
856277 PIN3 Psi+ INducibility Saccharomyces cerevisiae Anti-Longevity 15% Increase PIN3
31607 Pink1 PTEN-induced putative kinase 1 Drosophila melanogaster Pro-Longevity 18% Increase Pink1
34284 Pka-C1 cAMP-dependent protein kinase 1 Drosophila melanogaster Pro-Longevity Increase Pka-C1
2539781 pka1 cAMP-dependent protein kinase Schizosaccharomyces pombe Unannotated Increase pka1
176991 pkg-1 EGg Laying defective Caenorhabditis elegans Anti-Longevity 55% Increase pkg-1
852101 PKH1 Pkb-activating Kinase Homolog Saccharomyces cerevisiae Anti-Longevity 15% Increase PKH1
854053 PKH2 Pkb-activating Kinase Homolog Saccharomyces cerevisiae Anti-Longevity 20% Increase PKH2
852077 PKH3 Pkb-activating Kinase Homolog Saccharomyces cerevisiae Anti-Longevity 10% Increase PKH3
18792 Plau Plasminogen activator, urokinase Mus musculus Pro-Longevity 20% Increase Plau
2542497 plb1 phospholipase B homolog Plb1 Schizosaccharomyces pombe Anti-Longevity Increase plb1
266823 pme-1 Protein PME-1 Caenorhabditis elegans Anti-Longevity 29% Increase pme-1
850389 PMP1 Plasma Membrane Proteolipid Saccharomyces cerevisiae Necessary For Fitness Decrease PMP1
851869 PMP3 Plasma Membrane Proteolipid Saccharomyces cerevisiae Necessary For Fitness Decrease PMP3
852709 PMR1 Plasma Membrane ATPase Related Saccharomyces cerevisiae Anti-Longevity 40% Increase PMR1
855642 PMS1 PostMeiotic Segregation Saccharomyces cerevisiae Necessary For Fitness Decrease PMS1
851462 PMT1 Protein O-MannosylTransferase Saccharomyces cerevisiae Necessary For Fitness Decrease PMT1
851464 PMT5 putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 Saccharomyces cerevisiae Anti-Longevity 21% Increase PMT5
851902 PMT7 Pmt7p Saccharomyces cerevisiae Anti-Longevity 30% Increase PMT7
176833 pnc-1 Pyrazinamidase and NiCotinamidase Caenorhabditis elegans Pro-Longevity Decrease pnc-1
852846 PNC1 Pyrazinamidase and NiCotinamidase Saccharomyces cerevisiae Pro-Longevity Increase and Decrease PNC1
172327 pnk-1 PaNtothenate Kinase Caenorhabditis elegans Pro-Longevity Decrease pnk-1
854440 PNT1 PeNTamidine resistance Saccharomyces cerevisiae Necessary For Fitness Decrease PNT1
176784 pod-1 Polarity and Osmotic sensitivity Defect Caenorhabditis elegans Anti-Longevity 45% Increase pod-1
6194500 PODANSg7134 hypothetical protein Podospora anserina Anti-Longevity 18% Increase PODANSg7134
854684 POG1 Promoter Of Growth Saccharomyces cerevisiae Necessary For Fitness Decrease POG1
18975 Polg Polymerase (DNA directed), gamma Mus musculus Pro-Longevity Decrease Polg
179224 pos-1 POsterior Segregation Caenorhabditis elegans Anti-Longevity 20% Increase pos-1
36990 POSH Plenty of SH3s Drosophila melanogaster Pro-Longevity 14% Increase POSH
18736 Pou1f1 POU domain, class 1, transcription factor 1 Mus musculus Anti-Longevity 40% Increase Pou1f1
855309 PPA2 PyroPhosphatAse Saccharomyces cerevisiae Necessary For Fitness Decrease PPA2
19016 Pparg Peroxisome proliferator activated receptor gamma Mus musculus Pro-Longevity Increase and Decrease Pparg
851647 PPH3 Protein PHosphatase Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PPH3
32731 ppk23 pickpocket 23 Drosophila melanogaster Anti-Longevity 4% Decrease ppk23
32671 ppk28 pickpocket 28 Drosophila melanogaster Anti-Longevity 44% Increase ppk28
53892 Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform Mus musculus Pro-Longevity Decrease Ppm1d
2541963 ppr1 L-azetidine-2-carboxylic acid acetyltransferase Schizosaccharomyces pombe Anti-Longevity Increase ppr1
854992 PPZ1 Protein Phosphatase Z Saccharomyces cerevisiae Necessary For Fitness Decrease PPZ1
266858 prdx-2 PeRoxireDoXin Caenorhabditis elegans Pro-Longevity Decrease prdx-2
175573 prdx-3 PeRoxireDoXin Caenorhabditis elegans Pro-Longevity Decrease prdx-3
18477 Prdx1 Peroxiredoxin 1 Mus musculus Pro-Longevity Decrease Prdx1
853036 PRE9 proteasome core particle subunit alpha 3 Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PRE9
854713 PRK1 p53 Regulatory Kinase Saccharomyces cerevisiae Anti-Longevity 30% Increase PRK1
19088 Prkar2b protein kinase, cAMP dependent regulatory, type II beta Mus musculus Anti-Longevity 14% Increase Prkar2b
19127 Prop1 Prophet of Pit1, paired-like homeodomain transcription factor Mus musculus Anti-Longevity Increase Prop1
37123 Prp19 Pre-RNA processing factor 19 Drosophila melanogaster Pro-Longevity 25% Increase Prp19
856375 PRS3 PhosphoRibosylpyrophosphate Synthetase Saccharomyces cerevisiae Anti-Longevity 50% Increase PRS3
174392 prx-5 PeRoXisome assembly factor Caenorhabditis elegans Anti-Longevity 30% Increase prx-5
852215 PRX1 PeroxiRedoXin Saccharomyces cerevisiae Necessary For Fitness Decrease PRX1
3771951 Prx5 Peroxiredoxin 5 Drosophila melanogaster Pro-Longevity 30% Increase Prx5
853366 PRY1 Pathogen Related in Yeast Saccharomyces cerevisiae Necessary For Fitness 50% Decrease PRY1
855552 PSD1 PhosphatidylSerine Decarboxylase Saccharomyces cerevisiae Necessary For Fitness Decrease PSD1
851596 PST2 Pst2p Saccharomyces cerevisiae Anti-Longevity 36% Increase PST2
854257 PTC5 Phosphatase Two C Saccharomyces cerevisiae Necessary For Fitness 50% Decrease PTC5
43991 Pten CG5671 gene product from transcript CG5671-RB Drosophila melanogaster Pro-Longevity 13% Increase Pten
19211 Pten Phosphatase and tensin homolog Mus musculus Pro-Longevity Increase and Decrease Pten
856596 PTH1 Peptidyl-Trna Hydrolase Saccharomyces cerevisiae Necessary For Fitness Decrease PTH1
853522 PTK2 Putative serine/Threonine protein Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease PTK2
173362 ptr-23 PaTched Related family Caenorhabditis elegans Pro-Longevity 13% Decrease ptr-23
855716 PUB1 PolyUridylate Binding Saccharomyces cerevisiae Necessary For Fitness 25% Decrease PUB1
40958 puc puckered Drosophila melanogaster Anti-Longevity Increase puc
851132 PUN1 Plasma membrane protein Upregulated during Nitrogen stress Saccharomyces cerevisiae Necessary For Fitness Decrease PUN1
175708 pup-2 Poly(U) Polymerase Caenorhabditis elegans Anti-Longevity Increase pup-2
853965 PXL1 PaXillin-Like protein Saccharomyces cerevisiae Anti-Longevity Increase PXL1
179616 pyc-1 PYruvate Carboxylase Caenorhabditis elegans Anti-Longevity 5% Increase pyc-1
178415 qars-1 glutaminyl(Q) tRNA Synthetase Caenorhabditis elegans Anti-Longevity 40% Increase qars-1
852142 QCR7 ubiQuinol-cytochrome C oxidoReductase Saccharomyces cerevisiae Necessary For Fitness 30% Decrease QCR7
853273 QCR8 ubiQuinol-cytochrome C oxidoReductase Saccharomyces cerevisiae Necessary For Fitness Decrease QCR8
850901 QRI5 Qri5p Saccharomyces cerevisiae Necessary For Fitness Decrease QRI5
180862 R07E4.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase R07E4.3
180757 R08E3.3 Protein R08E3.3 Caenorhabditis elegans Anti-Longevity Increase R08E3.3
177932 R10H10.7 Protein R10H10.7 Caenorhabditis elegans Anti-Longevity 22% Increase R10H10.7
187837 R12B2.6 Protein R12B2.6 Caenorhabditis elegans Pro-Longevity 22% Decrease R12B2.6
172011 R12E2.2 hypothetical protein Caenorhabditis elegans Anti-Longevity 50% Increase R12E2.2
174554 R53.4 Protein R53.4 Caenorhabditis elegans Anti-Longevity 20% Increase R53.4
266836 rab-10 RAB family Caenorhabditis elegans Anti-Longevity 16% Increase rab-10
172755 rab-5 RAB family Caenorhabditis elegans Pro-Longevity 50% Decrease rab-5
174834 rab-7 RAB family Caenorhabditis elegans Pro-Longevity 32% Decrease rab-7
177895 rack-1 Guanine nucleotide-binding protein subunit beta-2-like 1 Caenorhabditis elegans Anti-Longevity 10% Increase rack-1
854878 RAD10 RADiation sensitive Saccharomyces cerevisiae Necessary For Fitness Decrease RAD10
853747 RAD27 Rad27p Saccharomyces cerevisiae Pro-Longevity 50% Decrease RAD27
851909 RAD34 Homologous to RAD4 Saccharomyces cerevisiae Anti-Longevity 30% Increase RAD34
856909 RAD4 RADiation sensitive Saccharomyces cerevisiae Necessary For Fitness Decrease RAD4
855471 RAD50 Subunit of MRX complex, with Mre11p and Xrs2p Saccharomyces cerevisiae Necessary For Fitness 70% Decrease RAD50
856831 RAD51 Strand exchange protein Saccharomyces cerevisiae Necessary For Fitness 40% Decrease RAD51
854976 RAD52 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) Saccharomyces cerevisiae Necessary For Fitness 70% Decrease RAD52
851648 RAD55 RADiation sensitive Saccharomyces cerevisiae Anti-Longevity Increase and Decrease RAD55
851567 RAD57 Rad57p Saccharomyces cerevisiae Necessary For Fitness 40% Decrease RAD57
851803 RAD9 Rad9p Saccharomyces cerevisiae Necessary For Fitness 50% Decrease RAD9
66679 Rae1 RAE1 RNA export 1 homolog (S. pombe) Mus musculus Pro-Longevity Decrease Rae1
174726 raga-1 RAs-related GTP-binding protein A Caenorhabditis elegans Anti-Longevity 27% Increase raga-1
178084 ragc-1 RAs-related GTP binding protein C homolog Caenorhabditis elegans Anti-Longevity 26% Increase ragc-1
175433 ral-1 RAL (Ras-related GTPase) homolog Caenorhabditis elegans Anti-Longevity 19% Increase ral-1
175659 rars-1 Probable arginine--tRNA ligase, cytoplasmic Caenorhabditis elegans Anti-Longevity 27% Increase rars-1
854268 RAS1 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway Saccharomyces cerevisiae Anti-Longevity 23% Increase RAS1
855625 RAS2 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous gr Saccharomyces cerevisiae Unclear 43% Increase RAS2
853490 RAV1 Regulator of (H+)-ATPase in Vacuolar membrane Saccharomyces cerevisiae Necessary For Fitness Decrease RAV1
31381 rb ruby Drosophila melanogaster Pro-Longevity Decrease rb
56190 Rbm38 RNA binding motif protein 38 Mus musculus Pro-Longevity 22% Decrease Rbm38
33498 Rbp9 RNA-binding protein 9 Drosophila melanogaster Pro-Longevity 33% Decrease Rbp9
177985 rbr-2 RB (Retinoblastoma Binding protein) Related Caenorhabditis elegans Unclear Increase and Decrease rbr-2
175788 rcan-1 Regulator of CAalciNeurin Caenorhabditis elegans Anti-Longevity 38% Increase rcan-1
855709 RCM1 Rcm1p Saccharomyces cerevisiae Anti-Longevity Increase RCM1
175522 rcq-5 ReCQ DNA helicase family Caenorhabditis elegans Pro-Longevity 37% Decrease rcq-5
851566 RCR2 Resistance to Congo Red 2 Saccharomyces cerevisiae Anti-Longevity 18% Increase RCR2
853226 RCY1 Rcy1p Saccharomyces cerevisiae Anti-Longevity Increase RCY1
31826 rdgA retinal degeneration A Drosophila melanogaster Anti-Longevity 44% Increase rdgA
2769007 Rdh CG14975-PA Drosophila melanogaster Pro-Longevity 8% Increase Rdh
2539930 reb1 RNA polymerase I transcription termination factor Reb1 Schizosaccharomyces pombe Anti-Longevity Increase reb1
178295 rec-8 hypothetical protein Caenorhabditis elegans Anti-Longevity 26% Increase rec-8
856115 REC8 Rec8p Saccharomyces cerevisiae Anti-Longevity 20% Increase REC8
851592 REG1 protein phosphatase regulator REG1 Saccharomyces cerevisiae Necessary For Fitness Decrease REG1
852569 REI1 Cytoplasmic pre-60S factor Saccharomyces cerevisiae Anti-Longevity 40% Increase REI1
850873 RFX1 Rfx1p Saccharomyces cerevisiae Anti-Longevity 20% Increase RFX1
854274 RGS2 Regulator of heterotrimeric G protein Signaling Saccharomyces cerevisiae Anti-Longevity 35% Increase RGS2
853828 RGT1 Restores Glucose Transport Saccharomyces cerevisiae Anti-Longevity Increase RGT1
851417 RGT2 Restores Glucose Transport Saccharomyces cerevisiae Anti-Longevity Increase RGT2
176207 rha-2 RNA HelicAse Caenorhabditis elegans Anti-Longevity 32% Increase rha-2
176327 rheb-1 Protein RHEB-1 Caenorhabditis elegans Anti-Longevity 19% Increase rheb-1
180721 rhi-1 RHo GDI Caenorhabditis elegans Pro-Longevity Decrease rhi-1
36281 rho-7 rhomboid-7 Drosophila melanogaster Pro-Longevity Decrease rho-7
2542773 rho2 rho2 Schizosaccharomyces pombe Anti-Longevity Increase rho2
855541 RHO5 Ras HOmolog Saccharomyces cerevisiae Necessary For Fitness Decrease RHO5
179427 ric-4 Resistance to Inhibitors of Cholinesterase Caenorhabditis elegans Anti-Longevity Decrease ric-4
3565035 rict-1 hypothetical protein Caenorhabditis elegans Unannotated 10% Increase rict-1
78757 Rictor RPTOR independent companion of MTOR, complex 2 Mus musculus Pro-Longevity 40% Decrease Rictor
852578 RIF1 RAP1-Interacting Factor Saccharomyces cerevisiae Pro-Longevity 30% Decrease RIF1
179958 ril-1 RNAi-Induced Longevity Caenorhabditis elegans Anti-Longevity 32% Increase ril-1
179725 ril-2 RNAi-Induced Longevity Caenorhabditis elegans Anti-Longevity Increase ril-2
850395 RIM1 Replication In Mitochondria Saccharomyces cerevisiae Anti-Longevity 20% Increase RIM1
855170 RIM11 Regulator of IME2 Saccharomyces cerevisiae Necessary For Fitness Decrease RIM11
850511 RIM15 Regulator of IME2 Saccharomyces cerevisiae Necessary For Fitness Decrease RIM15
852837 RIM8 Regulator of IME2 Saccharomyces cerevisiae Anti-Longevity Increase and Decrease RIM8
856689 RIP1 Rieske Iron-sulfur Protein Saccharomyces cerevisiae Anti-Longevity 15% Increase RIP1
855289 RKR1 RING domain mutant Killed by rtf1 deletion Saccharomyces cerevisiae Necessary For Fitness Decrease RKR1
172943 rla-0 60S acidic ribosomal protein P0 Caenorhabditis elegans Anti-Longevity 7% Increase rla-0
176525 rle-1 Regulation of Longevity by E3 ubiquitin ligase Caenorhabditis elegans Anti-Longevity Increase rle-1
856016 RLM1 Resistance to Lethality of MKK1P386 overexpression Saccharomyces cerevisiae Necessary For Fitness Decrease RLM1
850609 RMD8 Required for Meiotic nuclear Division Saccharomyces cerevisiae Necessary For Fitness Decrease RMD8
852771 RMD9 Required for Meiotic nuclear Division Saccharomyces cerevisiae Necessary For Fitness Decrease RMD9
175532 rnf-5 RiNg Finger protein Caenorhabditis elegans Anti-Longevity Increase rnf-5
855652 RNH201 RNase H Saccharomyces cerevisiae Anti-Longevity 50% Increase RNH201
175525 rnr-2 Protein RNR-2 Caenorhabditis elegans Anti-Longevity 14% Increase rnr-2
854744 RNR3 RiboNucleotide Reductase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease RNR3
851086 ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p Saccharomyces cerevisiae Anti-Longevity 50% Increase ROM2
855300 ROY1 Repressor Of Ypt52 Saccharomyces cerevisiae Necessary For Fitness Decrease ROY1
174238 rpa-1 Protein RPA-1 Caenorhabditis elegans Anti-Longevity 5% Increase rpa-1
175660 rpb-8 Protein RPB-8 Caenorhabditis elegans Anti-Longevity 6% Increase rpb-8
177491 rpc-1 RNA Polymerase, Class III Caenorhabditis elegans Anti-Longevity 36% Increase rpc-1
855386 RPD3 Histone deacetylase Saccharomyces cerevisiae Anti-Longevity 41% Increase RPD3
38565 Rpd3 CG7471-PA Drosophila melanogaster Anti-Longevity 52% Increase Rpd3
246599 Rpi Ribose-5-phosphate isomerase Drosophila melanogaster Anti-Longevity 38% Increase Rpi
40002 RpIIIC53 RNA polymerase III subunit C53 Drosophila melanogaster Anti-Longevity 11% Increase RpIIIC53
171853 rpl-1 60S ribosomal protein L10a Caenorhabditis elegans Anti-Longevity 23% Increase rpl-1
174311 rpl-10 60S ribosomal protein L10 Caenorhabditis elegans Anti-Longevity 20% Increase rpl-10
171692 rpl-17 60S ribosomal protein L17 Caenorhabditis elegans Anti-Longevity 13% Increase rpl-17
172201 rpl-19 Ribosomal Protein, Large subunit Caenorhabditis elegans Anti-Longevity Increase rpl-19
175796 rpl-23 60S ribosomal protein L23 Caenorhabditis elegans Anti-Longevity 18% Increase rpl-23
175501 rpl-3 60S ribosomal protein L3 Caenorhabditis elegans Anti-Longevity 29% Increase rpl-3
172921 rpl-30 Ribosomal Protein, Large subunit Caenorhabditis elegans Anti-Longevity 13% Increase rpl-30
173235 rpl-31 60S ribosomal protein L31 Caenorhabditis elegans Anti-Longevity 16% Increase rpl-31
172074 rpl-4 Ribosomal Protein, Large subunit Caenorhabditis elegans Anti-Longevity Increase rpl-4
171602 rpl-7 60S ribosomal protein L7 Caenorhabditis elegans Anti-Longevity 10% Increase rpl-7
177203 rpl-7A 60S ribosomal protein L7a Caenorhabditis elegans Anti-Longevity 12% Increase rpl-7A
176071 rpl-9 Ribosomal Protein, Large subunit Caenorhabditis elegans Anti-Longevity Increase rpl-9
850764 RPL10 ribosomal 60S subunit protein L10 Saccharomyces cerevisiae Anti-Longevity 24% Increase RPL10
856656 RPL12A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 35% Increase RPL12A
852026 RPL12B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 20% Increase RPL12B
851477 RPL13A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPL13A
855173 RPL13B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 50% Decrease RPL13B
855655 RPL16B ribosomal 60S subunit protein L16B Saccharomyces cerevisiae Anti-Longevity 23% Increase RPL16B
853262 RPL17B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 25% Decrease RPL17B
852379 RPL19A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 50% Increase RPL19A
852254 RPL19B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 20% Increase RPL19B
852742 RPL1B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 20% Increase RPL1B
855283 RPL20A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 40% Decrease RPL20A
854489 RPL20B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 50% Increase RPL20B
852489 RPL21A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPL21A
856026 RPL21B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 50% Increase RPL21B
850750 RPL22A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 90% Increase RPL22A
852191 RPL23A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 40% Increase RPL23A
851058 RPL26A ribosomal 60S subunit protein L26A Saccharomyces cerevisiae Anti-Longevity 22% Increase RPL26A
850592 RPL29 Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 35% Increase RPL29
854794 RPL2B ribosomal 60S subunit protein L2B Saccharomyces cerevisiae Anti-Longevity 38% Increase RPL2B
851484 RPL31A ribosomal 60S subunit protein L31A Saccharomyces cerevisiae Anti-Longevity Increase and Decrease RPL31A
854409 RPL33B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 15% Increase RPL33B
856784 RPL34A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 25% Decrease RPL34A
854759 RPL34B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 60% Increase RPL34B
851336 RPL35A ribosomal 60S subunit protein L35A Saccharomyces cerevisiae Anti-Longevity 41% Increase RPL35A
851419 RPL35B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 25% Increase RPL35B
850882 RPL37A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 50% Decrease RPL37A
852111 RPL37B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 35% Increase RPL37B
853250 RPL39 Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 45% Decrease RPL39
856156 RPL43A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 60% Decrease RPL43A
853557 RPL43B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPL43B
852319 RPL4A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 20% Increase RPL4A
854902 RPL6A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 25% Decrease RPL6A
851169 RPL6B ribosomal 60S subunit protein L6B Saccharomyces cerevisiae Anti-Longevity 40% Increase RPL6B
852804 RPL7A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 40% Increase RPL7A
850682 RPL8B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 25% Increase RPL8B
852730 RPL9A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPL9A
855658 RPL9B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPL9B
173744 rpn-11 Protein RPN-11 Caenorhabditis elegans Pro-Longevity 19% Decrease rpn-11
175972 rpn-6.1 Protein RPN-6.1 Caenorhabditis elegans Pro-Longevity Decrease rpn-6.1
851542 RPN4 Regulatory Particle Non-ATPase Saccharomyces cerevisiae Necessary For Fitness 40% Decrease RPN4
854283 RPO31 RPO31 Saccharomyces cerevisiae Anti-Longevity Increase RPO31
850507 RPO41 Rpo41p Saccharomyces cerevisiae Necessary For Fitness Decrease RPO41
851478 RPP1A Ribosomal Protein P1 Alpha Saccharomyces cerevisiae Necessary For Fitness 30% Decrease RPP1A
851427 RPP1B Ribosomal Protein P1 Beta Saccharomyces cerevisiae Anti-Longevity 40% Increase RPP1B
854118 RPP2A Ribosomal Protein P2 Alpha Saccharomyces cerevisiae Anti-Longevity Increase and Decrease RPP2A
851990 RPP2B Ribosomal Protein P2 Beta Saccharomyces cerevisiae Anti-Longevity 55% Increase RPP2B
175628 rps-0 40S ribosomal protein SA Caenorhabditis elegans Anti-Longevity 15% Increase rps-0
172061 rps-10 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity Increase rps-10
178083 rps-11 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity 30% Increase rps-11
175786 rps-12 Protein RPS-12 Caenorhabditis elegans Anti-Longevity 12% Increase rps-12
176006 rps-14 Protein RPS-14 Caenorhabditis elegans Anti-Longevity 17% Increase rps-14
172693 rps-15 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity 50% Increase rps-15
179998 rps-16 40S ribosomal protein S16 Caenorhabditis elegans Anti-Longevity 8% Increase rps-16
173309 rps-20 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity 24% Increase rps-20
175338 rps-22 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity Increase rps-22
178188 rps-23 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity 126% Increase rps-23
173342 rps-26 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity Increase rps-26
175879 rps-3 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity 32% Increase rps-3
178012 rps-5 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity 75% Increase rps-5
173260 rps-6 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity Increase rps-6
177503 rps-8 Ribosomal Protein, Small subunit Caenorhabditis elegans Anti-Longevity 18% Increase rps-8
850737 RPS0B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Necessary For Fitness 20% Decrease RPS0B
855270 RPS10B ribosomal 40S subunit protein S10B Saccharomyces cerevisiae Anti-Longevity Increase RPS10B
851589 RPS11A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPS11A
854551 RPS12 ribosomal 40S subunit protein S12 Saccharomyces cerevisiae Anti-Longevity 38% Increase RPS12
854984 RPS17A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Necessary For Fitness 15% Decrease RPS17A
852061 RPS18A ribosomal 40S subunit protein S18A Saccharomyces cerevisiae Anti-Longevity 15% Increase RPS18A
854982 RPS18B ribosomal 40S subunit protein S18B Saccharomyces cerevisiae Anti-Longevity 15% Increase RPS18B
854939 RPS1B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Necessary For Fitness 30% Decrease RPS1B
853305 RPS21B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Necessary For Fitness 20% Decrease RPS21B
856805 RPS24A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Anti-Longevity Increase and Decrease RPS24A
854741 RPS24B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Necessary For Fitness 20% Decrease RPS24B
856868 RPS26B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Anti-Longevity 20% Increase RPS26B
853700 RPS27A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Necessary For Fitness 20% Decrease RPS27A
856415 RPS27B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Necessary For Fitness 30% Decrease RPS27B
853610 RPS4A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Necessary For Fitness 15% Decrease RPS4A
856610 RPS4B Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Anti-Longevity Increase and Decrease RPS4B
856015 RPS6A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPS6A
852479 RPS6B ribosomal 40S subunit protein S6B Saccharomyces cerevisiae Anti-Longevity 45% Increase RPS6B
72508 Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 Mus musculus Anti-Longevity 19% Increase Rps6kb1
854263 RPS7A Ribosomal Protein of the Small subunit Saccharomyces cerevisiae Necessary For Fitness 40% Decrease RPS7A
179641 rpt-1 Protein RPT-1 Caenorhabditis elegans Pro-Longevity 28% Decrease rpt-1
853712 RPT1 proteasome regulatory particle base subunit RPT1 Saccharomyces cerevisiae Necessary For Fitness 33% Decrease RPT1
851557 RPT2 proteasome regulatory particle base subunit RPT2 Saccharomyces cerevisiae Necessary For Fitness 68% Decrease RPT2
852003 RPT3 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae Necessary For Fitness 55% Decrease RPT3
854284 RPT5 proteasome regulatory particle base subunit RPT5 Saccharomyces cerevisiae Necessary For Fitness 85% Decrease RPT5
852834 RPT6 proteasome regulatory particle base subunit RPT6 Saccharomyces cerevisiae Necessary For Fitness 63% Decrease RPT6
855951 RRD2 Resistant to Rapamycin Deletion Saccharomyces cerevisiae Necessary For Fitness Decrease RRD2
851637 RRG1 Required for Respiratory Growth Saccharomyces cerevisiae Necessary For Fitness 50% Decrease RRG1
854482 RRG7 Required for Respiratory Growth Saccharomyces cerevisiae Necessary For Fitness Decrease RRG7
856232 RRG8 Required for Respiratory Growth Saccharomyces cerevisiae Necessary For Fitness Decrease RRG8
855508 RRG9 Required for Respiratory Growth Saccharomyces cerevisiae Necessary For Fitness Decrease RRG9
856426 RRM3 rDNA Recombination Mutation Saccharomyces cerevisiae Necessary For Fitness 30% Decrease RRM3
851656 RRP8 25S rRNA (adenine645-N1)-methyltransferase Saccharomyces cerevisiae Unannotated RRP8
850412 RRT12 Regulator of rDNA Transcription Saccharomyces cerevisiae Necessary For Fitness Decrease RRT12
853592 RSF2 ReSpiration Factor Saccharomyces cerevisiae Necessary For Fitness Decrease RSF2
176554 rsks-1 RSK-pSeventy (RSK-p70 kinase) homolog Caenorhabditis elegans Anti-Longevity 47% Increase rsks-1
856776 RSM18 Ribosomal Small subunit of Mitochondria Saccharomyces cerevisiae Necessary For Fitness Decrease RSM18
851755 RSM24 Ribosomal Small subunit of Mitochondria Saccharomyces cerevisiae Necessary For Fitness Decrease RSM24
173013 rsr-1 Protein RSR-1 Caenorhabditis elegans Anti-Longevity 6% Increase rsr-1
174862 rsr-2 SR protein related Caenorhabditis elegans Pro-Longevity Decrease rsr-2
852444 RTC2 Restriction of Telomere Capping Saccharomyces cerevisiae Necessary For Fitness Decrease RTC2
855918 RTC6 Restriction of Telomere Capping Saccharomyces cerevisiae Necessary For Fitness Decrease RTC6
854087 RTG1 ReTroGrade regulation Saccharomyces cerevisiae Necessary For Fitness Decrease RTG1
852640 RTG2 ReTroGrade regulation Saccharomyces cerevisiae Necessary For Fitness Decrease RTG2
852171 RTG3 Rtg3p Saccharomyces cerevisiae Anti-Longevity Increase RTG3
851819 RTN1 ReTiculoN-like Saccharomyces cerevisiae Anti-Longevity Increase and Decrease RTN1
855919 RTT10 Regulator of Ty1 Transposition Saccharomyces cerevisiae Necessary For Fitness Decrease RTT10
856559 RTT107 Regulator of Ty1 Transposition Saccharomyces cerevisiae Necessary For Fitness 30% Decrease RTT107
32406 rut rutabaga Drosophila melanogaster Pro-Longevity Decrease rut
850367 RVS161 Reduced Viability on Starvation Saccharomyces cerevisiae Anti-Longevity Increase and Decrease RVS161
852392 RXT2 Rxt2p Saccharomyces cerevisiae Necessary For Fitness Decrease RXT2
41605 ry rosy Drosophila melanogaster Pro-Longevity Decrease ry
38654 S6k RPS6-p70-protein kinase Drosophila melanogaster Anti-Longevity Increase S6k
172778 sac-1 Protein SAC-1 Caenorhabditis elegans Pro-Longevity 25% Decrease sac-1
853668 SAC1 Suppressor of ACtin Saccharomyces cerevisiae Necessary For Fitness 40% Decrease SAC1
851707 SAC6 Suppressor of ACtin Saccharomyces cerevisiae Necessary For Fitness 40% Decrease SAC6
853460 SAG1 Sexual AGglutination Saccharomyces cerevisiae Necessary For Fitness Decrease SAG1
856866 SAK1 Snf1 Activating Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease SAK1
855641 SAL1 Suppressor of Aac2 Lethality Saccharomyces cerevisiae Necessary For Fitness 20% Decrease SAL1
850877 SAM1 S-AdenosylMethionine requiring Saccharomyces cerevisiae Anti-Longevity 20% Increase SAM1
181370 sams-1 S-Adenosyl Methionine Synthetase Caenorhabditis elegans Anti-Longevity 15% Increase sams-1
178446 sams-2 Caenorhabditis elegans Anti-Longevity 27% Increase sams-2
177355 sams-3 hypothetical protein Caenorhabditis elegans Anti-Longevity 50% Increase sams-3
855305 SAP30 SIT4 protein phosphatase Associated Protein Saccharomyces cerevisiae Necessary For Fitness Decrease SAP30
179592 sas-5 Spindle ASsembly abnormal Caenorhabditis elegans Anti-Longevity 30% Increase sas-5
852228 SAS3 Something About Silencing Saccharomyces cerevisiae Anti-Longevity Increase SAS3
851762 SAS4 Something About Silencing Saccharomyces cerevisiae Anti-Longevity Increase SAS4
175218 sbds-1 Shwachman-Bodian-Diamond Syndrome protein homolog Caenorhabditis elegans Pro-Longevity Decrease sbds-1
180366 sbt-1 Seven B Two (mammalian 7BT prohormone convertase chaperone) homolog Caenorhabditis elegans Pro-Longevity Decrease sbt-1
176512 sca-1 SERCA (Sarco-Endoplasmic Reticulum Calcium ATPase) Caenorhabditis elegans Anti-Longevity 19% Increase sca-1
179054 scd-2 Suppressor of Constitutive Dauer formation Caenorhabditis elegans Pro-Longevity Decrease scd-2
31129 Scgdelta Sarcoglycan delta Drosophila melanogaster Pro-Longevity 30% Decrease Scgdelta
856612 SCH9 Protein kinase that regulates signal transduction activity and G1 progression Saccharomyces cerevisiae Anti-Longevity 300% Increase SCH9
855254 SCJ1 S. Cerevisiae DnaJ Saccharomyces cerevisiae Necessary For Fitness Decrease SCJ1
2541867 sck2 serine/threonine protein kinase Sck2 Schizosaccharomyces pombe Anti-Longevity Increase sck2
186053 scl-1 SCP-Like extracellular protein Caenorhabditis elegans Pro-Longevity Decrease scl-1
191309 scl-20 SCP-Like extracellular protein Caenorhabditis elegans Pro-Longevity 18% Decrease scl-20
183342 scl-4 SCP-Like extracellular protein Caenorhabditis elegans Anti-Longevity Increase scl-4
183345 scl-8 SCP-Like extracellular protein Caenorhabditis elegans Anti-Longevity 18% Increase scl-8
173763 sco-1 Protein SCO-1 Caenorhabditis elegans Anti-Longevity 23% Increase sco-1
854549 SCP1 Scp1p Saccharomyces cerevisiae Anti-Longevity 65% Increase SCP1
853365 SCP160 S. cerevisiae protein involved in the Control of Ploidy Saccharomyces cerevisiae Anti-Longevity Increase and Decrease SCP160
187152 scrm-8 SCRaMblase (phospholipid scramblase) Caenorhabditis elegans Anti-Longevity Increase scrm-8
2541690 sdh1 succinate dehydrogenase Sdh1 (predicted) Schizosaccharomyces pombe Necessary For Fitness Decrease sdh1
853709 SDH1 succinate dehydrogenase flavoprotein subunit SDH1 Saccharomyces cerevisiae Anti-Longevity 25% Increase SDH1
850685 SDH2 succinate dehydrogenase iron-sulfur protein subunit SDH2 Saccharomyces cerevisiae Anti-Longevity 21% Increase SDH2
2541292 sdh4 TIM22 inner membrane protein import complex anchor subunit Tim18 Schizosaccharomyces pombe Anti-Longevity Increase sdh4
854083 SDH5 succinate dehydrogenase assembly factor SDH5 Saccharomyces cerevisiae Anti-Longevity 28% Increase SDH5
35590 SdhB Succinate dehydrogenase B Drosophila melanogaster Pro-Longevity 66% Decrease SdhB
41340 SdhC succinate dehydrogenase, cytochrome b556 subunit Drosophila melanogaster Pro-Longevity 22% Decrease SdhC
854693 SDP1 Stress-inducible Dual specificity Phosphatase Saccharomyces cerevisiae Anti-Longevity 25% Increase SDP1
852824 SDS23 homolog of S. pombe SDS23 Saccharomyces cerevisiae Anti-Longevity Increase SDS23
854725 SDS3 Suppressor of Defective Silencing Saccharomyces cerevisiae Necessary For Fitness Decrease SDS3
854734 SEC28 SECretory Saccharomyces cerevisiae Anti-Longevity 20% Increase SEC28
852469 SEC66 SECretory Saccharomyces cerevisiae Necessary For Fitness Decrease SEC66
853756 SEG2 Stability of Eisosomes Guaranteed Saccharomyces cerevisiae Anti-Longevity 20% Increase SEG2
175599 sel-5 Suppressor/Enhancer of Lin-12 Caenorhabditis elegans Anti-Longevity 29% Increase sel-5
181055 sem-5 SEx Muscle abnormal Caenorhabditis elegans Anti-Longevity 24% Increase sem-5
181716 ser-1 SERotonin/octopamine receptor family Caenorhabditis elegans Anti-Longevity 46% Increase ser-1
175322 ser-4 SERotonin/octopamine receptor family Caenorhabditis elegans Pro-Longevity Decrease ser-4
18787 Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus Anti-Longevity Increase Serpine1
171593 sesn-1 Sestrin homolog Caenorhabditis elegans Pro-Longevity Increase and Decrease sesn-1
187813 set-15 SET (trithorax/polycomb) domain containing Caenorhabditis elegans Anti-Longevity 10% Increase set-15
175662 set-2 SET (trithorax/polycomb) domain containing Caenorhabditis elegans Anti-Longevity 30% Increase set-2
178463 set-26 SET (trithorax/polycomb) domain containing Caenorhabditis elegans Anti-Longevity 22% Increase set-26
174045 set-4 SET (trithorax/polycomb) domain containing Caenorhabditis elegans Anti-Longevity 20% Increase set-4
181371 set-6 SET (trithorax/polycomb) domain containing Caenorhabditis elegans Pro-Longevity 10% Decrease set-6
177196 set-9 SET (trithorax/polycomb) domain containing Caenorhabditis elegans Anti-Longevity 22% Increase set-9
856519 SET1 histone methyltransferase SET1 Saccharomyces cerevisiae Necessary For Fitness 29% Decrease SET1
853271 SET2 SET domain-containing Saccharomyces cerevisiae Anti-Longevity Increase and Decrease SET2
853900 SET3 SET domain-containing Saccharomyces cerevisiae Necessary For Fitness Decrease SET3
2539545 set9 histone lysine H4-K20 methyltransferase Set9 Schizosaccharomyces pombe Anti-Longevity Increase set9
854307 SFL1 Suppressor gene for FLocculation Saccharomyces cerevisiae Anti-Longevity Increase SFL1
856060 SGF11 SAGA histone acetyltransferase complex subunit SGF11 Saccharomyces cerevisiae Anti-Longevity 26% Increase SGF11
850347 SGF29 SaGa associated Factor Saccharomyces cerevisiae Necessary For Fitness Decrease SGF29
852814 SGF73 SaGa associated Factor, 73 kDa Saccharomyces cerevisiae Necessary For Fitness Decrease SGF73
181697 sgk-1 Serum- and Glucocorticoid- inducible kinase homolog Caenorhabditis elegans Anti-Longevity Increase sgk-1
855228 SGS1 Sgs1p Saccharomyces cerevisiae Pro-Longevity 30% Decrease SGS1
854168 SGT2 Small Glutamine-rich Tetratricopeptide repeat-containing protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease SGT2
3565745 shc-1 Src Homology domain C-terminal, adaptor homolog Caenorhabditis elegans Pro-Longevity 38% Decrease shc-1
20416 Shc1 SHC (Src homology 2 domain containing) transforming protein 1 Mus musculus Anti-Longevity 30% Increase Shc1
2542338 shd1 cytoskeletal protein binding protein Sla1 family, Shd1 (predicted) Schizosaccharomyces pombe Anti-Longevity Increase shd1
852561 SHG1 Set1c, Hypothetical G Saccharomyces cerevisiae Necessary For Fitness 25% Decrease SHG1
852565 SHM1 Serine HydroxyMethyltransferase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease SHM1
850747 SHM2 Serine HydroxyMethyltransferase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease SHM2
853009 SHY1 SURF Homolog of Yeast Saccharomyces cerevisiae Necessary For Fitness Decrease SHY1
850768 SIC1 Substrate/Subunit Inhibitor of Cyclin-dependent protein kinase Saccharomyces cerevisiae Necessary For Fitness Decrease SIC1
176805 sid-2 Systemic RNA Interference Defective Caenorhabditis elegans Anti-Longevity Increase sid-2
852399 SIF2 Sir4p-Interacting Factor Saccharomyces cerevisiae Necessary For Fitness Decrease SIF2
83382 Siglece sialic acid binding Ig-like lectin E Mus musculus Pro-Longevity 17% Decrease Siglece
190339 sinh-1 SIN-1 (S. pombe stress activated protein kinase interactor) Homolog Caenorhabditis elegans Anti-Longevity Increase sinh-1
176471 sip-1 Stress-induced protein 1 Caenorhabditis elegans Pro-Longevity 18% Decrease sip-1
852032 SIP1 SNF1-Interacting Protein Saccharomyces cerevisiae Unclear Increase and Decrease SIP1
855213 SIP18 Salt Induced Protein Saccharomyces cerevisiae Necessary For Fitness 30% Decrease SIP18
852664 SIP2 Sip2p Saccharomyces cerevisiae Unclear Increase and Decrease SIP2
855464 SIP3 SNF1-Interacting Protein Saccharomyces cerevisiae Necessary For Fitness Decrease SIP3
177924 sir-2.1 Yeast SIR related (68.8 kD) (sir-2.1) Caenorhabditis elegans Pro-Longevity Increase and Decrease sir-2.1
34708 Sir2 CG5216-PA Drosophila melanogaster Pro-Longevity Increase and Decrease Sir2
851520 SIR2 Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) Saccharomyces cerevisiae Unclear 600% Increase SIR2
851163 SIR3 Silent information regulator Saccharomyces cerevisiae Necessary For Fitness 20% Decrease SIR3
851813 SIR4 Silent information regulator Saccharomyces cerevisiae Anti-Longevity Increase and Decrease SIR4
93759 Sirt1 Sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) Mus musculus Pro-Longevity Increase and Decrease Sirt1
42414 Sirt2 CG5085-PA Drosophila melanogaster Pro-Longevity 20% Decrease Sirt2
31480 Sirt4 Sirtuin 4 Drosophila melanogaster Pro-Longevity 20% Increase Sirt4
50721 Sirt6 sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) Mus musculus Pro-Longevity Increase and Decrease Sirt6
41254 Sirt6 CG6284-PB Drosophila melanogaster Pro-Longevity 20% Decrease Sirt6
209011 Sirt7 Sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) Mus musculus Pro-Longevity 59% Decrease Sirt7
853946 SIS2 SIt4 Suppressor Saccharomyces cerevisiae Anti-Longevity 50% Increase SIS2
852018 SIZ1 SAP and mIZ-finger domain Saccharomyces cerevisiae Necessary For Fitness 50% Decrease SIZ1
854036 SKM1 STE20/PAK homologous Kinase related to Morphogenesis Saccharomyces cerevisiae Necessary For Fitness 25% Decrease SKM1
177343 skn-1 SKiNhead Caenorhabditis elegans Pro-Longevity Increase and Decrease skn-1
853045 SKN1 Suppressor of Kre Null Saccharomyces cerevisiae Anti-Longevity 60% Increase SKN1
856613 SKN7 Suppressor of Kre Null Saccharomyces cerevisiae Necessary For Fitness Decrease SKN7
855554 SKO1 Suppressor of Kinase Overexpression Saccharomyces cerevisiae Necessary For Fitness Decrease SKO1
172775 skr-1 SKp1 Related (ubiquitin ligase complex component) Caenorhabditis elegans Pro-Longevity Decrease skr-1
172773 skr-2 SKp1 Related (ubiquitin ligase complex component) Caenorhabditis elegans Pro-Longevity Decrease skr-2
180148 skr-5 SKp1 Related (ubiquitin ligase complex component) Caenorhabditis elegans Anti-Longevity 10% Increase skr-5
852276 SLA1 Synthetic Lethal with ABP1 Saccharomyces cerevisiae Necessary For Fitness 60% Decrease SLA1
55961 Slc13a1 Solute carrier family 13 (sodium/sulfate symporters), member 1 Mus musculus Anti-Longevity 25% Increase Slc13a1
11739 Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus Pro-Longevity Decrease Slc25a4
186633 slcf-1 hypothetical protein Caenorhabditis elegans Anti-Longevity 40% Increase slcf-1
856852 SLX8 Synthetic Lethal of unknown (X) function Saccharomyces cerevisiae Anti-Longevity Increase and Decrease SLX8
176849 sma-10 hypothetical protein Caenorhabditis elegans Anti-Longevity 30% Increase sma-10
172418 smg-1 Suppressor with Morphological effect on Genitalia Caenorhabditis elegans Anti-Longevity 30% Increase smg-1
853144 SMI1 Suppressor of MAR Inhibitor Saccharomyces cerevisiae Necessary For Fitness Decrease SMI1
179243 smk-1 suppressor of MEK null Caenorhabditis elegans Pro-Longevity 21% Decrease smk-1
172783 smn-1 SMN (human Survival Motor Neuron gene) homolog Caenorhabditis elegans Pro-Longevity 26% Decrease smn-1
31738 Smox Smad on X Drosophila melanogaster Anti-Longevity 10% Increase Smox
853290 SNA3 Sna3p Saccharomyces cerevisiae Anti-Longevity 27% Increase SNA3
179193 snap-1 Protein SNAP-1 Caenorhabditis elegans Pro-Longevity 40% Decrease snap-1
176233 snap-29 Protein SNAP-29 Caenorhabditis elegans Pro-Longevity 49% Decrease snap-29
SNCA synuclein, alpha (non A4 component of amyloid precursor) Caenorhabditis elegans Pro-Longevity 25% Increase SNCA
852088 SNF1 AMP-activated serine/threonine protein kinase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease SNF1
43904 SNF1A SNF1A/AMP-activated protein kinase Drosophila melanogaster Pro-Longevity 20% Increase SNF1A
851333 SNF3 Sucrose NonFermenting Saccharomyces cerevisiae Anti-Longevity Increase SNF3
852763 SNF4 Protein kinase activator found in a complex containing Snf1p and members of the Sip1p/Sip2p/Gal83p f Saccharomyces cerevisiae Anti-Longevity 20% Increase SNF4
42515 SNF4Agamma SNF4/AMP-activated protein kinase gamma subunit Drosophila melanogaster Pro-Longevity 23% Decrease SNF4Agamma
854539 SNX3 Sorting NeXin Saccharomyces cerevisiae Anti-Longevity Increase SNX3
852035 SNX41 Sorting NeXin Saccharomyces cerevisiae Anti-Longevity Increase SNX41
31704 snz snazarus (sorting nexin lazarus) Drosophila melanogaster Anti-Longevity 85% Increase snz
216233 Socs2 Suppressor of cytokine signaling 2 Mus musculus Pro-Longevity 35% Decrease Socs2
39251 Sod Superoxide dismutase Drosophila melanogaster Pro-Longevity Increase and Decrease Sod
174141 sod-1 superoxide dismutase Caenorhabditis elegans Anti-Longevity Increase sod-1
172632 sod-2 Superoxide dismutase (24.5 kD) (sod-2) Caenorhabditis elegans Unclear 44% Increase sod-2
853568 SOD1 Cu, Zn superoxide dismutase Saccharomyces cerevisiae Pro-Longevity Increase and Decrease SOD1
856399 SOD2 Manganese-containing superoxide dismutase Saccharomyces cerevisiae Pro-Longevity Increase and Decrease SOD2
36878 Sod2 Superoxide dismutase 2 (Mn) Drosophila melanogaster Pro-Longevity Increase and Decrease Sod2
20656 Sod2 Superoxide dismutase 2, mitochondrial Mus musculus Pro-Longevity 43% Decrease Sod2
6649 SOD3 superoxide dismutase 3 Mus musculus Pro-Longevity Decrease SOD3
851569 SOK1 Suppressor Of Kinase Saccharomyces cerevisiae Anti-Longevity 50% Increase SOK1
850437 SOL2 Suppressor Of Los1-1 Saccharomyces cerevisiae Necessary For Fitness Decrease SOL2
855088 SOV1 Sov1p Saccharomyces cerevisiae Anti-Longevity 30% Increase SOV1
2542614 SPAC1399.04c uracil phosphoribosyltransferase (predicted) Schizosaccharomyces pombe Anti-Longevity Increase SPAC1399.04c
2542177 SPAC17H9.08 mitochondrial coenzyme A transporter (predicted) Schizosaccharomyces pombe Necessary For Fitness Decrease SPAC17H9.08
2541482 SPAC23D3.03c GTPase activating protein Schizosaccharomyces pombe Anti-Longevity Increase SPAC23D3.03c
2543101 SPAC323.03c sequence orphan Schizosaccharomyces pombe Anti-Longevity Increase SPAC323.03c
2543072 SPAC3A12.09c urease accessory protein UreD (predicted) Schizosaccharomyces pombe Anti-Longevity Increase SPAC3A12.09c
2543375 SPAC3H1.08c DUF1640 family protein Schizosaccharomyces pombe Anti-Longevity Increase SPAC3H1.08c
2542654 SPAC8E11.05c DUF5102 family conserved fungal protein Schizosaccharomyces pombe Anti-Longevity Increase SPAC8E11.05c
40562 Spargel Spargel Drosophila melanogaster Pro-Longevity 33% Increase Spargel
2539836 SPBC1198.07c SPBC1198.07c Schizosaccharomyces pombe Anti-Longevity Increase SPBC1198.07c
2539743 SPBC16A3.08c protein stm1 Schizosaccharomyces pombe Pro-Longevity Increase SPBC16A3.08c
2540026 SPBC16D10.08c heat shock protein Hsp104 (predicted) Schizosaccharomyces pombe Anti-Longevity Increase SPBC16D10.08c
2540834 SPBC18H10.18c SPBC18H10.18c Schizosaccharomyces pombe Anti-Longevity Increase SPBC18H10.18c
2540844 SPBC1921.04c SPBC1921.04c Schizosaccharomyces pombe Anti-Longevity Increase SPBC1921.04c
2540765 SPBC1D7.01 prefoldin subunit 1 (predicted) Schizosaccharomyces pombe Necessary For Fitness Decrease SPBC1D7.01
2540991 SPBC3H7.03c alpha-ketoglutarate dehydrogenase Schizosaccharomyces pombe Anti-Longevity Increase SPBC3H7.03c
2541246 SPBC8E4.02c SPBC8E4.02c Schizosaccharomyces pombe Anti-Longevity Increase SPBC8E4.02c
2541353 SPBP35G2.11c transcription related zf-ZZ type zinc finger protein Schizosaccharomyces pombe Anti-Longevity Increase SPBP35G2.11c
2541358 SPBP4H10.16c phosphatase activator (predicted) Schizosaccharomyces pombe Anti-Longevity Increase SPBP4H10.16c
851250 SPC72 Spindle Pole Component Saccharomyces cerevisiae Necessary For Fitness 80% Decrease SPC72
2539169 SPCC1235.11 hypothetical protein Schizosaccharomyces pombe Necessary For Fitness Decrease SPCC1235.11
2538949 SPCC320.03 SPCC320.03 Schizosaccharomyces pombe Anti-Longevity Increase SPCC320.03
2538708 SPCC594.01 DUF1769 family protein Schizosaccharomyces pombe Anti-Longevity Increase SPCC594.01
2538998 SPCC594.02c SPCC594.02c Schizosaccharomyces pombe Anti-Longevity Increase SPCC594.02c
2538820 SPCC70.05c putative serine/threonine protein kinase Schizosaccharomyces pombe Anti-Longevity Increase SPCC70.05c
2539472 SPCC794.03 SPCC794.03 Schizosaccharomyces pombe Anti-Longevity Increase SPCC794.03
177929 spe-26 Defective SPErmatogenesis Caenorhabditis elegans Anti-Longevity 65% Increase spe-26
172137 spe-5 Temporarily Assigned Gene name Caenorhabditis elegans Anti-Longevity 23% Increase spe-5
854105 SPE2 SPErmidine auxotroph Saccharomyces cerevisiae Necessary For Fitness 50% Decrease SPE2
171915 spg-7 human SPG (spastic paraplegia) Caenorhabditis elegans Anti-Longevity 23% Increase spg-7
176857 spl-1 Sphingosine Phosphate Lyase Caenorhabditis elegans Pro-Longevity 22% Decrease spl-1
854737 SPO22 SPOrulation Saccharomyces cerevisiae Anti-Longevity Increase SPO22
2540745 spo4 serine/threonine protein kinase Spo4 Schizosaccharomyces pombe Anti-Longevity Increase spo4
171681 spp-17 SaPosin-like Protein family Caenorhabditis elegans Anti-Longevity 20% Increase spp-17
855965 SPP1 Spp1p Saccharomyces cerevisiae Unannotated SPP1
180722 spr-3 Suppressor of presenilin protein 3 Caenorhabditis elegans Anti-Longevity 26% Increase spr-3
852135 SPS1 SPorulation Specific Saccharomyces cerevisiae Anti-Longevity 25% Increase SPS1
855518 SPS19 SPorulation Specific transcript Saccharomyces cerevisiae Necessary For Fitness 30% Decrease SPS19
175172 spt-4 SPT transcription factor family Caenorhabditis elegans Anti-Longevity Increase spt-4
853315 SPT10 SuPpressor of Ty Saccharomyces cerevisiae Necessary For Fitness Decrease SPT10
852955 SPT4 SuPpressor of Ty's Saccharomyces cerevisiae Anti-Longevity 40% Increase SPT4
850744 SPT8 SuPpressor of Ty Saccharomyces cerevisiae Necessary For Fitness Decrease SPT8
189783 sptf-3 Specificity Protein) Transcription Factor Caenorhabditis elegans Pro-Longevity 24% Decrease sptf-3
173389 sptl-1 Serine Palmitoyl Transferase famiLy Caenorhabditis elegans Anti-Longevity 33% Increase sptl-1
18412 Sqstm1 sequestosome 1 Mus musculus Pro-Longevity 34% Decrease Sqstm1
852168 SRO77 Suppressor of rho3 Saccharomyces cerevisiae Necessary For Fitness Decrease SRO77
853353 SRS2 Srs2p Saccharomyces cerevisiae Pro-Longevity 30% Decrease SRS2
190663 srt-56 Serpentine Receptor, class T Caenorhabditis elegans Anti-Longevity 30% Increase srt-56
188048 sru-17 Serpentine Receptor, class U Caenorhabditis elegans Anti-Longevity Increase sru-17
189964 srw-100 Serpentine Receptor, class W Caenorhabditis elegans Anti-Longevity Increase srw-100
188136 srw-20 Serpentine Receptor, class W Caenorhabditis elegans Anti-Longevity Increase srw-20
189965 srw-99 Serpentine Receptor, class W Caenorhabditis elegans Anti-Longevity Increase srw-99
852203 SSA3 Stress-Seventy subfamily A Saccharomyces cerevisiae Anti-Longevity 50% Increase SSA3
856840 SSA4 Stress-Seventy subfamily A Saccharomyces cerevisiae Necessary For Fitness Decrease SSA4
853503 SSC1 Hsp70 family ATPase SSC1 Saccharomyces cerevisiae Anti-Longevity 40% Increase SSC1
851887 SSD1 Ssd1p Saccharomyces cerevisiae Unclear Increase and Decrease SSD1
856463 SSF1 Suppressor of ste4 (Four) Saccharomyces cerevisiae Anti-Longevity Increase and Decrease SSF1
850692 SSK1 Suppressor of Sensor Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease SSK1
855765 SSK2 Suppressor of Sensor Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease SSK2
856065 SSN3 Suppressor of SNf1 Saccharomyces cerevisiae Necessary For Fitness 50% Decrease SSN3
855844 SSO1 Sso1p Saccharomyces cerevisiae Necessary For Fitness 50% Decrease SSO1
855221 SSO2 Sso2p Saccharomyces cerevisiae Necessary For Fitness Decrease SSO2
850952 SSP120 Ssp120p Saccharomyces cerevisiae Necessary For Fitness Decrease SSP120
42428 Stat92E Signal-transducer and activator of transcription protein at 92E Drosophila melanogaster Pro-Longevity 33% Decrease Stat92E
851076 STE11 STErile Saccharomyces cerevisiae Necessary For Fitness 25% Decrease STE11
851426 STF1 Stf1p Saccharomyces cerevisiae Necessary For Fitness Decrease STF1
56424 Stub1 STIP1 homology and U-Box containing protein 1 Mus musculus Pro-Longevity Decrease Stub1
34119 Su(var)205 Suppressor of variegation 205 Drosophila melanogaster Pro-Longevity Increase and Decrease Su(var)205
36424 sug sugarbabe Drosophila melanogaster Pro-Longevity 9% Increase sug
44046 sun Stunted Drosophila melanogaster Anti-Longevity Increase sun
856050 SUR1 SUppressor of Rvs161 and rvs167 mutations Saccharomyces cerevisiae Necessary For Fitness Decrease SUR1
44498 Surf1 surfeit gene 1 Drosophila melanogaster Anti-Longevity Increase Surf1
20930 Surf1 surfeit gene 1 Mus musculus Anti-Longevity 20% Increase Surf1
856078 SUV3 Suv3p Saccharomyces cerevisiae Anti-Longevity 25% Increase SUV3
851222 SWC3 SWr Complex Saccharomyces cerevisiae Anti-Longevity Increase and Decrease SWC3
852532 SWC5 SWr Complex Saccharomyces cerevisiae Necessary For Fitness 50% Decrease SWC5
851265 SWD1 Set1c, WD40 repeat protein Saccharomyces cerevisiae Necessary For Fitness 20% Decrease SWD1
852472 SWD3 Set1c, WD40 repeat protein Saccharomyces cerevisiae Necessary For Fitness 15% Decrease SWD3
853252 SWE1 Saccharomyces WEe1 Saccharomyces cerevisiae Necessary For Fitness Decrease SWE1
851704 SWF1 Spore Wall Formation Saccharomyces cerevisiae Necessary For Fitness 30% Decrease SWF1
851724 SWI5 SWItching deficient Saccharomyces cerevisiae Anti-Longevity 20% Increase SWI5
850879 SWI6 SWItching deficient Saccharomyces cerevisiae Necessary For Fitness Decrease SWI6
855643 SWS2 Sick Without Securin Saccharomyces cerevisiae Necessary For Fitness Decrease SWS2
852004 SXM1 Suppressor of mRNA eXport Mutant Saccharomyces cerevisiae Necessary For Fitness Decrease SXM1
854351 SYC1 Similar to Ysh1 C-terminal Saccharomyces cerevisiae Necessary For Fitness Decrease SYC1
181255 syd-2 SYnapse Defective Caenorhabditis elegans Pro-Longevity Decrease syd-2
855999 SYH1 SmY2 Homolog Saccharomyces cerevisiae Necessary For Fitness 20% Decrease SYH1
850953 SYM1 Stress-inducible Yeast Mpv17 Saccharomyces cerevisiae Necessary For Fitness 50% Decrease SYM1
182490 symk-1 Protein SYMK-1 Caenorhabditis elegans Anti-Longevity 24% Increase symk-1
853453 SYS1 Sys1p Saccharomyces cerevisiae Necessary For Fitness Decrease SYS1
173459 T02H6.11 Protein T02H6.11 Caenorhabditis elegans Anti-Longevity 60% Increase T02H6.11
188077 T05A1.5 T05A1.5b Caenorhabditis elegans Anti-Longevity 20% Increase T05A1.5
176864 T07A9.8 Protein T07A9.8 Caenorhabditis elegans Anti-Longevity 24% Increase T07A9.8
177339 T12E12.1 hypothetical protein Caenorhabditis elegans Anti-Longevity 30% Increase T12E12.1
188527 T15B12.1 INSulin related Caenorhabditis elegans Anti-Longevity 40% Increase T15B12.1
179551 T19B10.2 Protein T19B10.2 Caenorhabditis elegans Pro-Longevity 34% Decrease T19B10.2
176023 T20H4.5 Protein T20H4.5 Caenorhabditis elegans Anti-Longevity 51% Increase T20H4.5
172857 T23D8.3 Protein T23D8.3 Caenorhabditis elegans Anti-Longevity 26% Increase T23D8.3
177968 T25B9.1 hypothetical protein Caenorhabditis elegans Anti-Longevity Increase T25B9.1
176772 T27E9.2 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase T27E9.2
173863 T27F7.1 Protein T27F7.1 Caenorhabditis elegans Pro-Longevity 34% Decrease T27F7.1
176780 T28A8.6 Protein T28A8.6 Caenorhabditis elegans Anti-Longevity 28% Increase T28A8.6
176566 T28D6.4 Protein T28D6.4 Caenorhabditis elegans Anti-Longevity 33% Increase T28D6.4
856098 TAE2 Translation Associated Element Saccharomyces cerevisiae Necessary For Fitness 30% Decrease TAE2
855974 TAF14 TATA binding protein-Associated Factor Saccharomyces cerevisiae Anti-Longevity Increase and Decrease TAF14
175693 tag-174 Temporarily Assigned Gene name Caenorhabditis elegans Anti-Longevity 25% Increase tag-174
851068 TAL1 TransALdolase Saccharomyces cerevisiae Anti-Longevity 20% Increase TAL1
177202 tald-1 Transaldolase Caenorhabditis elegans Anti-Longevity 14% Increase tald-1
852619 TAN1 Trna AcetylatioN Saccharomyces cerevisiae Necessary For Fitness Decrease TAN1
174790 tars-1 Threonyl Amino-acyl tRNA Synthetase Caenorhabditis elegans Anti-Longevity 12% Increase tars-1
854139 TAT2 aromatic amino acid transmembrane transporter TAT2 Saccharomyces cerevisiae Anti-Longevity 23% Increase TAT2
181574 tatn-1 Tyrosine AminoTraNsferase Caenorhabditis elegans Anti-Longevity 10% Increase tatn-1
176297 tax-4 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 100% Increase tax-4
177943 tax-6 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 27% Increase tax-6
174680 tba-4 Tubulin alpha chain Caenorhabditis elegans Anti-Longevity Increase tba-4
176568 tba-7 TuBulin, Alpha Caenorhabditis elegans Anti-Longevity 13% Increase tba-7
175519 tbb-2 Tubulin beta-2 chain Caenorhabditis elegans Anti-Longevity 5% Increase tbb-2
180784 tbc-7 TBC (Tre-2/Bub2/Cdc16) domain family Caenorhabditis elegans Pro-Longevity Decrease tbc-7
176054 tbp-1 TATA-Binding Protein Caenorhabditis elegans Pro-Longevity 21% Decrease tbp-1
854903 TCB3 Tcb3p Saccharomyces cerevisiae Anti-Longevity 18% Increase TCB3
174150 tcer-1 TransCription Elongation Regulator homolog Caenorhabditis elegans Pro-Longevity 15% Increase tcer-1
852332 TCM62 TriCarboxylic acid cycle Mutant Saccharomyces cerevisiae Necessary For Fitness Decrease TCM62
851146 TDA5 Topoisomerase I Damage Affected Saccharomyces cerevisiae Necessary For Fitness 30% Decrease TDA5
853465 TDH2 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 Saccharomyces cerevisiae Anti-Longevity 29% Increase TDH2
174436 tdp-1 Protein TDP-1 Caenorhabditis elegans Anti-Longevity 20% Increase tdp-1
854772 TED1 Trafficking of Emp24p/Erv25p-dependent cargo Disrupted Saccharomyces cerevisiae Necessary For Fitness Decrease TED1
39048 teq Tequila Drosophila melanogaster Anti-Longevity 31% Increase teq
21750 Terf2 telomeric repeat binding factor 2 Mus musculus Anti-Longevity Decrease Terf2
21752 Tert Telomerase reverse transcriptase Mus musculus Pro-Longevity Increase Tert
796551 tert telomerase reverse transcriptase Danio rerio Pro-Longevity 60% Decrease tert
177515 tes-1 Temporarily Assigned Gene name Caenorhabditis elegans Anti-Longevity 60% Increase tes-1
2541941 tfs1 transcription elongation factor TFIIS Schizosaccharomyces pombe Anti-Longevity Increase tfs1
855361 TGL3 TriacylGlycerol Lipase Saccharomyces cerevisiae Anti-Longevity Increase TGL3
33569 Thor CG8846 gene product from transcript CG8846-RA Drosophila melanogaster Pro-Longevity 22% Increase Thor
850420 THR4 THReonine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease THR4
853933 TIF1 Translation Initiation Factor Saccharomyces cerevisiae Anti-Longevity Increase and Decrease TIF1
853303 TIF2 Translation Initiation Factor Saccharomyces cerevisiae Anti-Longevity Increase and Decrease TIF2
2539738 tif213 putative translation initiation factor eIF2 gamma subunit tif213 Schizosaccharomyces pombe Anti-Longevity Increase tif213
853071 TIF4631 Translation Initiation Factor Saccharomyces cerevisiae Anti-Longevity 20% Increase TIF4631
852833 TIF4632 Translation Initiation Factor Saccharomyces cerevisiae Anti-Longevity 20% Increase TIF4632
173041 timm-23 Translocase, Inner Mitochondrial Membrane Caenorhabditis elegans Pro-Longevity 7% Decrease timm-23
172302 tin-44 Probable mitochondrial import inner membrane translocase subunit tim-44 Caenorhabditis elegans Pro-Longevity 11% Decrease tin-44
850827 TIS11 similar to the mammalian TPA Induced Sequence gene family Saccharomyces cerevisiae Anti-Longevity 30% Increase TIS11
177906 tkt-1 Protein TKT-1 Caenorhabditis elegans Anti-Longevity 25% Increase tkt-1
9164870 TLC1 telomerase_RNA Saccharomyces cerevisiae Pro-Longevity Increase and Decrease TLC1
172676 tlf-1 TBP-Like Factor Caenorhabditis elegans Pro-Longevity 33% Decrease tlf-1
853809 TMA19 Translation Machinery Associated Saccharomyces cerevisiae Anti-Longevity 30% Increase TMA19
180740 tmem-135 K02G10.3 Caenorhabditis elegans Unannotated Decrease tmem-135
43036 to takeout Drosophila melanogaster Pro-Longevity 26% Increase to
172209 tom-1 TOMosyn synaptic protein Caenorhabditis elegans Pro-Longevity 33% Decrease tom-1
852068 TOM1 Temperature dependent Organization in Mitotic nucleus Saccharomyces cerevisiae Anti-Longevity 30% Increase TOM1
856517 TOM71 Translocase of the Outer Mitochondrial membrane Saccharomyces cerevisiae Necessary For Fitness Decrease TOM71
173436 tomm-22 Translocase of Outer Mitochondrial Membrane Caenorhabditis elegans Pro-Longevity 14% Decrease tomm-22
266847 top-1 TOPoisomerase Caenorhabditis elegans Pro-Longevity 19% Decrease top-1
854156 TOP1 TOPoisomerase Saccharomyces cerevisiae Necessary For Fitness 60% Decrease TOP1
35236 Top3alpha Topoisomerase 3alpha Drosophila melanogaster Pro-Longevity 20% Decrease Top3alpha
21976 Top3b Topoisomerase (DNA) III beta Mus musculus Pro-Longevity Decrease Top3b
106021 Topors Topoisomerase I binding, arginine/serine-rich Mus musculus Pro-Longevity 42% Decrease Topors
47396 Tor Target of rapamycin Drosophila melanogaster Anti-Longevity Increase Tor
853529 TOR1 PIK-related protein kinase and rapamycin target Saccharomyces cerevisiae Anti-Longevity 30% Increase TOR1
852696 TOS3 Target Of Sbf Saccharomyces cerevisiae Anti-Longevity Increase and Decrease TOS3
852783 TOS8 Target Of Sbf Saccharomyces cerevisiae Anti-Longevity Increase and Decrease TOS8
176825 tpa-1 TPA (tetradecanoyl phorbol acetate) resistant Caenorhabditis elegans Anti-Longevity 28% Increase tpa-1
852988 TPC1 Thiamine Pyrophosphate Carrier Saccharomyces cerevisiae Necessary For Fitness 20% Decrease TPC1
853275 TPK1 Takashi's Protein Kinase Saccharomyces cerevisiae Necessary For Fitness 40% Decrease TPK1
855898 TPK2 Tpk2p Saccharomyces cerevisiae Anti-Longevity 25% Increase TPK2
853688 TPK3 Takashi's Protein Kinase Saccharomyces cerevisiae Necessary For Fitness 15% Decrease TPK3
855645 TPM1 TroPoMyosin Saccharomyces cerevisiae Necessary For Fitness 40% Decrease TPM1
850631 TPO1 Transporter of POlyamines Saccharomyces cerevisiae Pro-Longevity Increase and Decrease TPO1
22019 Tpp2 Tripeptidyl peptidase II Mus musculus Pro-Longevity Decrease Tpp2
2542498 tps3 alpha,alpha-trehalose-phosphate synthase Schizosaccharomyces pombe Anti-Longevity Increase tps3
38065 trh trachealess Drosophila melanogaster Anti-Longevity 90% Increase trh
178619 trim-9 Protein TRIM-9 Caenorhabditis elegans Anti-Longevity Increase trim-9
856077 TRM44 TRna Methyltransferase Saccharomyces cerevisiae Necessary For Fitness Decrease TRM44
854994 TRM9 TRna Methyltransferase Saccharomyces cerevisiae Anti-Longevity Increase TRM9
22059 Trp53 Transformation related protein 53 Mus musculus Pro-Longevity 23% Decrease Trp53
27223 Trp53bp1 Transformation related protein 53 binding protein 1 Mus musculus Anti-Longevity Increase Trp53bp1
22061 Trp63 Transformation related protein 63 Mus musculus Pro-Longevity 70% Decrease Trp63
22062 Trp73 transformation related protein 73 Mus musculus Pro-Longevity 31% Decrease Trp73
178118 trpa-1 Protein TRPA-1 Caenorhabditis elegans Pro-Longevity 34% Increase trpa-1
193034 Trpv1 transient receptor potential cation channel, subfamily V, member 1 Mus musculus Anti-Longevity 16% Increase Trpv1
851686 TRS85 TRapp Subunit Saccharomyces cerevisiae Necessary For Fitness Decrease TRS85
181863 trx-1 ThioRedoXin Caenorhabditis elegans Pro-Longevity Decrease trx-1
34281 Trx-2 thioredoxin-2 Drosophila melanogaster Pro-Longevity Decrease Trx-2
850732 TRX1 ThioRedoXin Saccharomyces cerevisiae Necessary For Fitness 50% Decrease TRX1
31760 Trxr-1 Thioredoxin reductase-1 Drosophila melanogaster Pro-Longevity Increase Trxr-1
31443 TrxT Thioredoxin T Drosophila melanogaster Pro-Longevity 15% Increase TrxT
173856 try-1 TRYpsin-like protease Caenorhabditis elegans Anti-Longevity Increase try-1
854980 TSA1 thioredoxin peroxidase TSA1 Saccharomyces cerevisiae Pro-Longevity Increase TSA1
42862 Tsc1 CG6147-PA Tuberous sclerosis complex genes 1 Drosophila melanogaster Pro-Longevity Increase Tsc1
192059 tsp-3 TetraSPanin 3 Caenorhabditis elegans Anti-Longevity 41% Increase tsp-3
35615 Tsp42Ef Tetraspanin 42Ef Drosophila melanogaster Anti-Longevity 18% Increase Tsp42Ef
173327 ttm-5 Putative sphingolipid delta(4)-desaturase/C4-hydroxylase Caenorhabditis elegans Anti-Longevity 40% Increase ttm-5
186958 ttr-1 TransThyretin-Related family domain Caenorhabditis elegans Anti-Longevity 19% Increase ttr-1
176312 ttr-5 TransThyretin-Related family domain Caenorhabditis elegans Anti-Longevity 14% Increase ttr-5
180313 ttx-1 Protein TTX-1 Caenorhabditis elegans Pro-Longevity 25% Decrease ttx-1
181357 ttx-3 abnormal ThermoTaXis Caenorhabditis elegans Pro-Longevity 10% Decrease ttx-3
174312 tub-1 TUBby-related Caenorhabditis elegans Anti-Longevity Increase tub-1
175398 tufm-1 TU elongation Factor (EF-Tu), Mitochondrial Caenorhabditis elegans Anti-Longevity 89% Increase tufm-1
851677 TVP15 Tlg2-Vesicle Protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease TVP15
851657 TVP23 Tlg2-Vesicle Protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease TVP23
852971 TWF1 TWinFilin Saccharomyces cerevisiae Necessary For Fitness 50% Decrease TWF1
22166 Txn1 Thioredoxin 1 Mus musculus Pro-Longevity 35% Increase Txn1
854470 UAF30 Upstream Activation Factor subunit Saccharomyces cerevisiae Anti-Longevity Increase UAF30
177073 ubc-13 UBiquitin Conjugating enzyme Caenorhabditis elegans Pro-Longevity Decrease ubc-13
851015 UBC12 UBiquitin-Conjugating Saccharomyces cerevisiae Anti-Longevity 50% Increase UBC12
856704 UBC8 UBiquitin-Conjugating Saccharomyces cerevisiae Necessary For Fitness 50% Decrease UBC8
24108 Ubd ubiquitin D Mus musculus Anti-Longevity 20% Increase Ubd
179039 ubh-1 UBiquitin C-terminal Hydrolase (family 1) Caenorhabditis elegans Pro-Longevity Decrease ubh-1
259626 ubh-3 UBiquitin C-terminal Hydrolase (family 1) Caenorhabditis elegans Pro-Longevity Decrease ubh-3
174289 ubh-4 UBiquitin C-terminal Hydrolase Caenorhabditis elegans Anti-Longevity Increase ubh-4
850620 UBI4 Ubiquitin Saccharomyces cerevisiae Necessary For Fitness Decrease UBI4
852349 UBP14 Ubp14p Saccharomyces cerevisiae Necessary For Fitness Decrease UBP14
850562 UBP6 Ubp6p Saccharomyces cerevisiae Necessary For Fitness 32% Decrease UBP6
855263 UBP8 UBiquitin-specific processing Protease Saccharomyces cerevisiae Necessary For Fitness Decrease UBP8
850711 UBR2 putative ubiquitin-protein ligase UBR2 Saccharomyces cerevisiae Anti-Longevity 67% Increase UBR2
854995 UBX2 Ubx2p Saccharomyces cerevisiae Anti-Longevity 24% Increase UBX2
855089 UBX4 UBiquitin regulatory X Saccharomyces cerevisiae Necessary For Fitness Decrease UBX4
7351 UCP2 uncoupling protein 2 (mitochondrial, proton carrier) Drosophila melanogaster Pro-Longevity 30% Increase UCP2
22228 Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus Pro-Longevity 20% Increase Ucp2
175772 ucr-1 Ubiquinol-Cytochrome c oxidoReductase complex Caenorhabditis elegans Anti-Longevity 110% Increase ucr-1
175248 ucr-2.3 Ubiquinol-Cytochrome c oxidoReductase complex Caenorhabditis elegans Anti-Longevity 15% Increase ucr-2.3
3565860 ufd-1 Ubiquitin Fusion Degradation (yeast UFD homolog) Caenorhabditis elegans Pro-Longevity 64% Decrease ufd-1
851337 UFD2 Ubiquitin Fusion Degradation Saccharomyces cerevisiae Necessary For Fitness Decrease UFD2
852902 UGA1 Utilization of GAba Saccharomyces cerevisiae Anti-Longevity 50% Increase UGA1
851384 UGA3 Utilization of GAba Saccharomyces cerevisiae Anti-Longevity 75% Increase UGA3
171778 ule-1 Uterine Lumin Expressed/locailized Caenorhabditis elegans Anti-Longevity 24% Decrease ule-1
4927009 ule-2 Uterine Lumin Expressed/locailized Caenorhabditis elegans Anti-Longevity 26% Decrease ule-2
179497 ule-3 Uterine Lumin Expressed/locailized Caenorhabditis elegans Anti-Longevity 27% Decrease ule-3
178331 ule-4 UPF0375 protein C08F11.11 Caenorhabditis elegans Anti-Longevity 26% Decrease ule-4
181365 ule-5 Uterine Lumin Expressed/locailized Caenorhabditis elegans Anti-Longevity 27% Decrease ule-5
175704 ulp-1 Ubiquitin-Like Protease Caenorhabditis elegans Pro-Longevity 22% Decrease ulp-1
851788 UME6 Unscheduled Meiotic gene Expression Saccharomyces cerevisiae Necessary For Fitness 40% Decrease UME6
852471 UMP1 Ump1p Saccharomyces cerevisiae Pro-Longevity Increase and Decrease UMP1
180990 unc-10 UNCoordinated Caenorhabditis elegans Anti-Longevity Decrease unc-10
172497 unc-13 UNCoordinated Caenorhabditis elegans Anti-Longevity 150% Increase unc-13
178284 unc-26 UNCoordinated Caenorhabditis elegans Anti-Longevity 50% Increase unc-26
178233 unc-31 UNCoordinated Caenorhabditis elegans Anti-Longevity 150% Increase unc-31
176257 unc-32 UNCoordinated Caenorhabditis elegans Anti-Longevity Increase unc-32
176155 unc-36 unc-36 Caenorhabditis elegans Anti-Longevity 34% Increase unc-36
174544 unc-4 UNCoordinated Caenorhabditis elegans Unannotated 100% Increase unc-4
180311 unc-51 UNCoordinated Caenorhabditis elegans Unclear Increase and Decrease unc-51
175126 unc-52 UNCoordinated Caenorhabditis elegans Anti-Longevity 11% Increase unc-52
178640 unc-60 UNCoordinated Caenorhabditis elegans Pro-Longevity Decrease unc-60
178845 unc-62 UNCoordinated Caenorhabditis elegans Anti-Longevity 38% Increase unc-62
176743 unc-64 UNCoordinated Caenorhabditis elegans Unannotated Increase unc-64
180014 unc-76 UNCoordinated Caenorhabditis elegans Unannotated 50% Increase unc-76
179033 unc-83 UNCoordinated Caenorhabditis elegans Anti-Longevity Increase unc-83
852963 UPF3 UP Frameshift Saccharomyces cerevisiae Necessary For Fitness Decrease UPF3
850865 UPS2 UnProceSsed Saccharomyces cerevisiae Necessary For Fitness Decrease UPS2
855492 URE2 Ure2p Saccharomyces cerevisiae Anti-Longevity 20% Increase URE2
852009 URH1 URidine Hydrolase Saccharomyces cerevisiae Anti-Longevity 24% Increase URH1
172782 usp-48 Protein USP-48 Caenorhabditis elegans Pro-Longevity Decrease usp-48
855871 USV1 Up in StarVation Saccharomyces cerevisiae Anti-Longevity Increase USV1
853916 UTH1 Uth1p Saccharomyces cerevisiae Anti-Longevity 15% Increase UTH1
181110 utx-1 Protein UTX-1 Caenorhabditis elegans Anti-Longevity 30% Increase utx-1
173794 vab-1 Variable ABnormal morphology Caenorhabditis elegans Pro-Longevity 20% Increase vab-1
856713 VAB2 VAc8p Binding Saccharomyces cerevisiae Necessary For Fitness Decrease VAB2
850296 VAC17 VACuole related Saccharomyces cerevisiae Necessary For Fitness Decrease VAC17
856702 VAC8 VACuole related Saccharomyces cerevisiae Necessary For Fitness Decrease VAC8
854234 VAM10 VAcuolar Morphogenesis Saccharomyces cerevisiae Necessary For Fitness Decrease VAM10
854273 VAM3 VAcuolar Morphogenesis Saccharomyces cerevisiae Necessary For Fitness 60% Decrease VAM3
852660 VAM7 VAcuolar Morphogenesis Saccharomyces cerevisiae Necessary For Fitness 70% Decrease VAM7
180579 vang-1 Protein VANG-1 Caenorhabditis elegans Anti-Longevity 40% Increase vang-1
853980 VBA5 Vacuolar Basic Amino acid transporter Saccharomyces cerevisiae Anti-Longevity Increase VBA5
174743 vha-6 Vacuolar H ATPase Caenorhabditis elegans Anti-Longevity 24% Increase vha-6
34997 VhaSFD Vacuolar H+-ATPase SFD subunit Drosophila melanogaster Pro-Longevity 10% Increase VhaSFD
181321 vhl-1 von Hippel-Lindau tumor suppressor homolog Caenorhabditis elegans Anti-Longevity 30% Increase vhl-1
851834 VHS1 Viable in a Hal3 Sit4 background Saccharomyces cerevisiae Anti-Longevity Increase and Decrease VHS1
854220 VHS3 Viable in a Hal3 Sit4 background Saccharomyces cerevisiae Necessary For Fitness Decrease VHS3
851088 VID22 Vacuolar Import and Degradation Saccharomyces cerevisiae Necessary For Fitness 50% Decrease VID22
852624 VID30 Vacuolar Import and Degradation Saccharomyces cerevisiae Anti-Longevity Increase and Decrease VID30
31201 Vinc Vinculin Drosophila melanogaster Pro-Longevity 150% Increase Vinc
181034 vit-1 Vitellogenin-1 Caenorhabditis elegans Anti-Longevity 40% Increase vit-1
180781 vit-2 VITellogenin structural genes (yolk protein genes) Caenorhabditis elegans Anti-Longevity Increase vit-2
180630 vit-5 VITellogenin structural genes (yolk protein genes) Caenorhabditis elegans Anti-Longevity Increase vit-5
851342 VMA1 Vacuolar Membrane Atpase Saccharomyces cerevisiae Necessary For Fitness 30% Decrease VMA1
852424 VMA2 Vacuolar Membrane Atpase Saccharomyces cerevisiae Necessary For Fitness 80% Decrease VMA2
852997 VMA21 Vma21p Saccharomyces cerevisiae Necessary For Fitness 60% Decrease VMA21
851168 VMA6 Vma6p Saccharomyces cerevisiae Necessary For Fitness 60% Decrease VMA6
851618 VMS1 VCP/Cdc48-associated Mitochondrial Stress-responsive Saccharomyces cerevisiae Necessary For Fitness 25% Decrease VMS1
854444 VPH1 Vacuolar pH Saccharomyces cerevisiae Anti-Longevity Increase and Decrease VPH1
175913 vps-16 related to yeast Vacuolar Protein Sorting factor Caenorhabditis elegans Pro-Longevity 21% Decrease vps-16
171654 vps-20 Protein VPS-20 Caenorhabditis elegans Pro-Longevity Decrease vps-20
175672 vps-22 Protein VPS-22 Caenorhabditis elegans Pro-Longevity 43% Decrease vps-22
176221 vps-33.1 Vacuolar sorting protein Caenorhabditis elegans Pro-Longevity 15% Decrease vps-33.1
179520 vps-36 VPS-36 Caenorhabditis elegans Pro-Longevity 27% Decrease vps-36
178944 vps-37 related to yeast Vacuolar Protein Sorting factor Caenorhabditis elegans Pro-Longevity 44% Decrease vps-37
855101 VPS20 Vacuolar Protein Sorting 20 Saccharomyces cerevisiae Necessary For Fitness 16% Decrease VPS20
854256 VPS21 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness Decrease VPS21
853825 VPS24 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness Decrease VPS24
853566 VPS25 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness Decrease VPS25
855739 VPS27 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness Decrease VPS27
855983 VPS30 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness Decrease VPS30
850941 VPS34 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness 60% Decrease VPS34
851074 VPS38 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness Decrease VPS38
851653 VPS41 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness 40% Decrease VPS41
854235 VPS5 Vacuolar Protein Sorting Saccharomyces cerevisiae Anti-Longevity Increase VPS5
853042 VPS62 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness Decrease VPS62
2542362 vps66 vps66 Schizosaccharomyces pombe Anti-Longevity Increase vps66
853590 VPS70 Vacuolar Protein Sorting Saccharomyces cerevisiae Anti-Longevity Increase VPS70
855475 VPS75 Vacuolar Protein Sorting Saccharomyces cerevisiae Anti-Longevity Increase VPS75
851261 VPS8 Vacuolar Protein Sorting Saccharomyces cerevisiae Necessary For Fitness Decrease VPS8
174004 vrk-1 Vaccinia Related Kinase Caenorhabditis elegans Pro-Longevity 36% Decrease vrk-1
851051 VRP1 VeRProlin Saccharomyces cerevisiae Necessary For Fitness 50% Decrease VRP1
850878 VTA1 VpsTwenty Associated Saccharomyces cerevisiae Necessary For Fitness Decrease VTA1
189167 W03G1.5 Protein W03G1.5 Caenorhabditis elegans Anti-Longevity 54% Increase W03G1.5
189168 W03G1.8 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase W03G1.8
176635 wah-1 Worm AIF (apoptosis inducing factor) Homolog Caenorhabditis elegans Anti-Longevity 13% Increase wah-1
172518 wdr-23 WD Repeat protein Caenorhabditis elegans Anti-Longevity 24% Increase wdr-23
175474 wdr-5.1 Temporarily Assigned Gene name Caenorhabditis elegans Anti-Longevity 30% Increase wdr-5.1
854208 WHI2 WHIskey Saccharomyces cerevisiae Necessary For Fitness 40% Decrease WHI2
855524 WHI3 WHIskey Saccharomyces cerevisiae Necessary For Fitness 25% Decrease WHI3
175681 wip-1 Wiskott-Aldrich syndrome protein (WASP)-Interacting Protein and gene assignment Caenorhabditis elegans Pro-Longevity Decrease wip-1
856357 WSC4 cell Wall integrity and Stress response Component Saccharomyces cerevisiae Necessary For Fitness 30% Decrease WSC4
172896 wts-1 WarTS (Drosophila) protein kinase homolog Caenorhabditis elegans Anti-Longevity 21% Increase wts-1
171647 wwp-1 WW domain Protein (E3 ubiquitin ligase) Caenorhabditis elegans Pro-Longevity Increase and Decrease wwp-1
175541 xbp-1 Protein XBP-1 Caenorhabditis elegans Unannotated xbp-1
22590 Xpa Xeroderma pigmentosum, complementation group A Mus musculus Pro-Longevity Decrease Xpa
22596 Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 Mus musculus Pro-Longevity 40% Decrease Xrcc5
14375 Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 Mus musculus Pro-Longevity Decrease Xrcc6
177202 Y24D9A.8 Transaldolase Caenorhabditis elegans Anti-Longevity 26% Increase Y24D9A.8
176705 Y37D8A.12 Protein Y37D8A.12 Caenorhabditis elegans Anti-Longevity Increase Y37D8A.12
178791 Y39H10A.6 Protein Y39H10A.6 Caenorhabditis elegans Anti-Longevity Increase Y39H10A.6
189848 Y43C5A.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase Y43C5A.3
259544 Y43F4B.7 Protein Y43F4B.7 Caenorhabditis elegans Anti-Longevity 11% Increase Y43F4B.7
3565323 Y43H11AL.2 Protein Y43H11AL.2 Caenorhabditis elegans Anti-Longevity Increase Y43H11AL.2
189958 Y46G5A.6 Caenorhabditis elegans Pro-Longevity Decrease Y46G5A.6
189968 Y46H3C.6 Protein Y46H3C.6 Caenorhabditis elegans Anti-Longevity Increase Y46H3C.6
176544 Y47D3A.29 hypothetical protein Caenorhabditis elegans Pro-Longevity 22% Decrease Y47D3A.29
171622 Y48G1A.4 Protein Y48G1A.4 Caenorhabditis elegans Anti-Longevity 21% Increase Y48G1A.4
173332 Y54E5A.7 Protein Y54E5A.7 Caenorhabditis elegans Anti-Longevity Increase Y54E5A.7
175017 Y54G9A.7 hypothetical protein Caenorhabditis elegans Anti-Longevity 12% Increase Y54G9A.7
176922 Y55F3AM.3 Protein Y55F3AM.3 Caenorhabditis elegans Pro-Longevity 9% Decrease Y55F3AM.3
176622 Y56A3A.19 Protein Y56A3A.19 Caenorhabditis elegans Anti-Longevity 37% Increase Y56A3A.19
190326 Y56A3A.9 Y56A3A.9 Caenorhabditis elegans Anti-Longevity Increase Y56A3A.9
171646 Y65B4BR.5 Protein Y65B4BR.5 Caenorhabditis elegans Anti-Longevity 17% Increase Y65B4BR.5
3565081 Y71H2AM.5 hypothetical protein Caenorhabditis elegans Anti-Longevity 40% Increase Y71H2AM.5
190615 Y71H2AR.2 Protein Y71H2AR.2 Caenorhabditis elegans Anti-Longevity Increase Y71H2AR.2
176951 Y77E11A.7 Y77E11A.7b Caenorhabditis elegans Pro-Longevity 24% Decrease Y77E11A.7
853300 YAK1 serine/threonine protein kinase YAK1 Saccharomyces cerevisiae Unannotated YAK1
177237 yars-1 YARS-1 Caenorhabditis elegans Anti-Longevity 55% Increase yars-1
43508 yata CG1973 gene product from transcript CG1973-RA Drosophila melanogaster Pro-Longevity Decrease yata
852346 YBR056W 17-beta-hydroxysteroid dehydrogenase-like protein Saccharomyces cerevisiae Necessary For Fitness Decrease YBR056W
852526 YBR225W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness 40% Decrease YBR225W
852540 YBR238C hypothetical protein Saccharomyces cerevisiae Anti-Longevity 30% Increase YBR238C
852587 YBR284W metallo-dependent hydrolase superfamily protein Saccharomyces cerevisiae Necessary For Fitness Decrease YBR284W
850360 YCP4 Ycp4p Saccharomyces cerevisiae Necessary For Fitness Decrease YCP4
850410 YCR043C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YCR043C
850417 YCR050C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YCR050C
856018 YDC1 Yeast DihydroCeramidase Saccharomyces cerevisiae Anti-Longevity Increase and Decrease YDC1
851502 YDL057W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YDL057W
851663 YDR089W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness 30% Decrease YDR089W
851702 YDR124W hypothetical protein Saccharomyces cerevisiae Anti-Longevity Increase and Decrease YDR124W
851710 YDR132C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness 35% Decrease YDR132C
851835 YDR248C gluconokinase Saccharomyces cerevisiae Anti-Longevity 20% Increase YDR248C
851855 YDR262W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness 30% Decrease YDR262W
856935 YER186C hypothetical protein Saccharomyces cerevisiae Anti-Longevity 30% Increase YER186C
856937 YER187W hypothetical protein Saccharomyces cerevisiae Anti-Longevity 30% Increase YER187W
851437 YFH1 Yeast Frataxin Homolog Saccharomyces cerevisiae Pro-Longevity 50% Decrease YFH1
852874 YGL010W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YGL010W
852615 YGL235W hypothetical protein Saccharomyces cerevisiae Anti-Longevity Increase and Decrease YGL235W
852944 YGR053C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YGR053C
853031 YGR130C hypothetical protein Saccharomyces cerevisiae Anti-Longevity 30% Increase YGR130C
853165 YGR250C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YGR250C
853387 YHC3 Yeast Homolog of human Cln3 Saccharomyces cerevisiae Necessary For Fitness 20% Decrease YHC3
856381 YHL008C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YHL008C
854811 YIA6 Yia6p Saccharomyces cerevisiae Necessary For Fitness 30% Decrease YIA6
850423 YIH1 Yeast Impact Homolog Saccharomyces cerevisiae Necessary For Fitness Decrease YIH1
854733 YIL077C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YIL077C
853294 YJL147C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YJL147C
853845 YKL023W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YKL023W
853794 YKL069W hypothetical protein Saccharomyces cerevisiae Pro-Longevity Decrease YKL069W
855328 YKU70 Subunit of the telomeric Ku complex (Yku70p-Yku80p) Saccharomyces cerevisiae Necessary For Fitness Decrease YKU70
855132 YKU80 Subunit of the telomeric Ku complex (Yku70p-Yku80p) Saccharomyces cerevisiae Necessary For Fitness Decrease YKU80
851021 YLR312C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YLR312C
851141 YLR422W hypothetical protein Saccharomyces cerevisiae Anti-Longevity 25% Increase YLR422W
851182 YLR460C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness 30% Decrease YLR460C
856135 YME1 Yeast Mitochondrial Escape Saccharomyces cerevisiae Necessary For Fitness 50% Decrease YME1
855022 YMR010W hypothetical protein Saccharomyces cerevisiae Anti-Longevity 30% Increase YMR010W
855032 YMR018W hypothetical protein Saccharomyces cerevisiae Anti-Longevity 35% Increase YMR018W
855108 YMR084W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YMR084W
855125 YMR099C glucose-6-phosphate 1-epimerase Saccharomyces cerevisiae Necessary For Fitness Decrease YMR099C
855202 YMR166C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness 20% Decrease YMR166C
855531 YNL190W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YNL190W
855803 YNR066C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease YNR066C
854177 YOR012W hypothetical protein Saccharomyces cerevisiae Anti-Longevity Increase YOR012W
854217 YOR052C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YOR052C
853198 YOR1 Yeast Oligomycin Resistance Saccharomyces cerevisiae Pro-Longevity Increase and Decrease YOR1
851627 YOS9 Yeast OS-9 homolog Saccharomyces cerevisiae Necessary For Fitness 10% Decrease YOS9
852481 YPC1 Yeast Phyto-Ceramidase Saccharomyces cerevisiae Necessary For Fitness 15% Decrease YPC1
853733 YPK1 Yeast Protein Kinase Saccharomyces cerevisiae Necessary For Fitness 20% Decrease YPK1
855953 YPL150W non-specific serine/threonine protein kinase Saccharomyces cerevisiae Necessary For Fitness Decrease YPL150W
855876 YPL225W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YPL225W
854061 YPQ1 Ypq1p Saccharomyces cerevisiae Necessary For Fitness 36% Decrease YPQ1
856121 YPR011C hypothetical protein Saccharomyces cerevisiae Necessary For Fitness 20% Decrease YPR011C
856276 YPR153W hypothetical protein Saccharomyces cerevisiae Necessary For Fitness Decrease YPR153W
850966 YPT6 Yeast Protein Two Saccharomyces cerevisiae Anti-Longevity 30% Increase YPT6
855012 YPT7 Yeast Protein Two Saccharomyces cerevisiae Necessary For Fitness 40% Decrease YPT7
856409 YSC84 Ysc84p Saccharomyces cerevisiae Anti-Longevity 25% Increase YSC84
853186 YTA7 Yeast Tat-binding Analog Saccharomyces cerevisiae Anti-Longevity 50% Increase YTA7
853562 YUH1 Yeast Ubiquitin Hydrolase Saccharomyces cerevisiae Necessary For Fitness 30% Decrease YUH1
853302 YUR1 mannosyltransferase YUR1 Saccharomyces cerevisiae Anti-Longevity 19% Increase YUR1
854844 YVH1 Yeast vaccinia virus VH1 Homolog Saccharomyces cerevisiae Anti-Longevity 50% Increase YVH1
178827 ZC132.3 Protein ZC132.3 Caenorhabditis elegans Anti-Longevity 26% Increase ZC132.3
175727 ZC395.10 Co-chaperone protein daf-41 Caenorhabditis elegans Unannotated ZC395.10
855316 ZDS1 Zds1p Saccharomyces cerevisiae Anti-Longevity 37% Increase ZDS1
854931 ZDS2 Zillion Different Screens Saccharomyces cerevisiae Pro-Longevity 20% Decrease ZDS2
171670 zfh-2 Protein ZFH-2 Caenorhabditis elegans Pro-Longevity 45% Decrease zfh-2
176237 zfp-1 Zinc Finger Protein Caenorhabditis elegans Pro-Longevity Decrease zfp-1
851879 ZIP1 molecular ZIPper Saccharomyces cerevisiae Necessary For Fitness 30% Decrease ZIP1
174151 ZK1127.5 Protein ZK1127.5 Caenorhabditis elegans Anti-Longevity 24% Increase ZK1127.5
176088 ZK686.2 Protein ZK686.2 Caenorhabditis elegans Anti-Longevity 24% Increase ZK686.2
178096 ZK809.3 Protein ZK809.3 Caenorhabditis elegans Anti-Longevity 100% Increase ZK809.3
230709 Zmpste24 zinc metallopeptidase, STE24 homolog (S. cerevisiae) Mus musculus Pro-Longevity Decrease Zmpste24
2540150 zrg17 cation diffusion family zinc membrane transporter Zrg17 Schizosaccharomyces pombe Anti-Longevity Increase zrg17
852335 ZTA1 ZeTA-crystallin Saccharomyces cerevisiae Anti-Longevity Increase and Decrease ZTA1
179257 ztf-12 Zinc finger Transcription Factor family Caenorhabditis elegans Pro-Longevity Decrease ztf-12
32974 Zw Zwischenferment Drosophila melanogaster Pro-Longevity 38% Increase Zw
855480 ZWF1 ZWischenFerment Saccharomyces cerevisiae Anti-Longevity Increase ZWF1