- Symbol
- Txn1
- Aliases
- ADF; Txn; Trx1; AW550880
- Name
- Thioredoxin 1
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- TXN plays a role in regulating cellular redox status and perhaps oxidative stress
- Observations
- Overexpression in mice resulted in no overall effects on lifespan, although it could be beneficial in the earlier part of life.
- Lifespan Effect
- Noeffect
- Longevity Category
- Not Recorded
- Primary reference
-
- Observations
- Overexpression in transgenic mice resulted in extended median and maximum (35%) lifespan.
- % change in max lifespan
- Maximum lifespan is approximately 35% higher.
- % change in avg or median lifespan
- Median lifespan is approximately 35% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as TRX1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as TXN
- CellAge
- A homolog of this gene for Homo sapiens is present as TXN
- Danio rerio
- txn
- Danio rerio
- zgc:56493
- Homo sapiens
- TXN
- Rattus norvegicus
- Txn1
- Saccharomyces cerevisiae
- TRX1
- Saccharomyces cerevisiae
- TRX2
- Schizosaccharomyces pombe
- trx1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (22166)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Txn1 (Mus musculus)