- Symbol
- aak-2
- Name
- AMP-Activated Kinase
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Energy sensor and signal transduction
- Observations
- Transgenic animals with a higher aak-2 gene dose live on average 13% longer than controls.
- % change in avg or median lifespan
- Mean lifespan is 13% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Constitutively activated aak-2 increased worm lifespan however induced detrimental pleiotropic side effects including small body size and a reduced reproductive capacity. Worms also showed increased heat resistance, demonstrating a 125% increase in median lifespan at 33 degrees Celsius compared to wild type animals. The lifespan extension effect was dependent on crtc-1 at low temperatures but not high ones.
- Lifespan Effect
- Increases
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Constitutively activated aak-2 increased worm lifespan however induced detrimental pleiotropic side effects including small body size and a reduced reproductive capacity. Worms also showed increased heat resistance, demonstrating a 125% increase in median lifespan at 33 degrees Celsius compared to wild type animals. The lifespan extension effect was dependent on crtc-1 at low temperatures but not high ones.
- Lifespan Effect
- Increases
- Genetic Manipulation
- Overexpression
- Primary reference
-
- Observations
- Constitutively activated aak-2 increased worm lifespan however induced detrimental pleiotropic side effects including small body size and a reduced reproductive capacity. Worms also showed increased heat resistance, demonstrating a 125% increase in median lifespan at 33 degrees Celsius compared to wild type animals. The lifespan extension effect was dependent on crtc-1 at low temperatures but not high ones.
- Lifespan Effect
- Increases
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Constitutively activated aak-2 increased worm lifespan however induced detrimental pleiotropic side effects including small body size and a reduced reproductive capacity. Worms also showed increased heat resistance, demonstrating a 125% increase in median lifespan at 33 degrees Celsius compared to wild type animals. The lifespan extension effect was dependent on crtc-1 at low temperatures but not high ones.
- Lifespan Effect
- Increases
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Could be a sensor that couples energy levels and insulin-like signals to lifespan. Knockout mutants have a 12% shorter lifespan.
- % change in avg or median lifespan
- Lifespan is 12% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- 37% decrease in median lifespna in daf-2 background and 54% decrease in lifespan in a wild-type background
- % change in avg or median lifespan
- Median lifespan is 54% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SNF1
- A homolog of this gene for Drosophila melanogaster is present as SNF1A
- GenDR gene manipulations
- This gene is present as aak-2
- LongevityMap
- A homolog of this gene for Homo sapiens is present as PRKAA1
- CellAge
- A homolog of this gene for Homo sapiens is present as PRKAA2
- Danio rerio
- prkaa2
- Danio rerio
- prkaa1
- Drosophila melanogaster
- AMPKalpha
- Homo sapiens
- PRKAA1
- Homo sapiens
- PRKAA2
- Mus musculus
- Prkaa2
- Mus musculus
- Prkaa1
- Rattus norvegicus
- Prkaa2
- Rattus norvegicus
- Prkaa1
- Saccharomyces cerevisiae
- SNF1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (181727)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar