Caenorhabditis elegansGenAge entry for age-1 (Caenorhabditis elegans)

Gene information (ID: 7)

Symbol
age-1
Name
AGEing alteration AGE-1, abnormal DAuer Formation DAF-23
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Phosphoinositide-3-kinase

Potential relevance to longevity and/or ageing

Observations
65 % increase in mean lifespan and a 110 % increase in maximum lifespan at 25 degrees. age-1 mutant hermaphrodites show a 50% slower rate of mortality acceleration than wild-type.
% change in max lifespan
Maximum lifespan is 110% higher.
% change in avg or median lifespan
Average lifespan is 65% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Mutants presented a double adult lifespan.
    % change in avg or median lifespan
    Lifespan is two-fold higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Knockout mutants have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan.
      % change in max lifespan
      Maximum lifespan is 65-110% higher.
      % change in avg or median lifespan
      Average lifespan is 40-65% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Knockout
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        170% mean lifespan extension
        % change in avg or median lifespan
        Average lifespan is 170% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference
          Observations
          C. elegans strains bearing homozygous nonsense mutations in the age-1 gene, which encodes the class-I phosphatidylinositol 3-kinase catalytic subunit (PI3KCS), produce progeny that were thought to undergo obligatory developmental arrest. After prolonged developmental times at 15 - 20 C, they mature into extremely long-lived adults with near-normal feeding rates and motility. They survive to a median of 145-190 days at 20 C, with nearly 10-fold extension of both median and maximum adult lifespan relative to N2DRM, a long-lived wild-type stock into which the null mutant was outcrossed. PI3K-null adults, although a little less thermotolerant, are considerably more resistant to oxidative and electrophilic stresses than worms bearing normal or less long-lived alleles. Their unprecedented factorial gains in survival, under both normal and toxic environments, are attributed to elimination of residual and maternally-contributed PI3KCS or its products, and consequent modification of kinase signaling cascades.
          % change in max lifespan
          Maximum lifespan is nearly 10-fold greater.
          % change in avg or median lifespan
          Average lifespan is nearly 10-fold greater.
          Lifespan Effect
          Increase
          Genetic Manipulation
          Mutation
          Longevity Category
          Anti-Longevity
          Primary reference

            In other databases

            GenAge model organism genes
            • A homolog of this gene for Saccharomyces cerevisiae is present as VPS34
            GenDR gene manipulations
            • This gene is present as age-1
            LongevityMap
            • A homolog of this gene for Homo sapiens is present as PIK3CG

            Homologs in other organisms

            Danio rerio
            si:rp71-17i16.5
            Danio rerio
            pik3cg
            Homo sapiens
            PIK3CG
            Mus musculus
            Pik3cg
            Rattus norvegicus
            Pik3cg
            Saccharomyces cerevisiae
            VPS34

            External links

            WormBase
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            Ensembl
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            Entrez Gene
            View on Entrez Gene database (174762)
            Homologues
            Search HomoloGene
            UniProt
            Search
            Internet
            Search Google or Search Google Scholar