Caenorhabditis elegansGenAge entry for lin-40 (Caenorhabditis elegans)

Gene information (ID: 216)

Symbol
lin-40
Name
abnormal cell LINeage
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Histone deacetylation

Potential relevance to longevity and/or ageing

Observations
Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
% change in avg or median lifespan
Average lifespan is 18% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Overexpressing egr-1 extends lifespan (17-25%) and confers resistance to multiple stresses, while decreasing egr-1 levels suppresses the long lifespan of insulin signaling and germline mutants.
    % change in avg or median lifespan
    Lifespan is 17-25% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      RNA interference decreased median lifespan by 24% in wild type animals, 38% in a daf-2 background and 24% in daf-2/daf-16 double mutants.
      % change in avg or median lifespan
      Median lifespan is 24% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        LongevityMap
        • A homolog of this gene for Homo sapiens is present as MTA3

        Homologs in other organisms

        Danio rerio
        mta3
        Danio rerio
        mta1
        Danio rerio
        mta2
        Drosophila melanogaster
        MTA1-like
        Homo sapiens
        MTA1
        Homo sapiens
        MTA2
        Homo sapiens
        MTA3
        Mus musculus
        Mta1
        Mus musculus
        Mta3
        Mus musculus
        Mta2
        Rattus norvegicus
        Mta3
        Rattus norvegicus
        Mta2
        Rattus norvegicus
        Mta1

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (178788)
        Homologues
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        UniProt
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        Internet
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