- Symbol
- Adra1b
- Name
- adrenergic receptor, alpha 1b
- Organism
- Mus musculus (AnAge)
- Observations
- Transgenic mice overexpressing a CAM form of the adrenergic receptor, alpha 1b (Adra1b), display a shorter lifespan (mean 11% shorter) when compared to wild-type mice. When comparing each sex separately, the mean lifespan difference was significant only for female mice. Maximal lifespan of mutant mice was significantly shorter than that of WT mice. Female mutants had a significantly shorter maximal lifespan than female WT animals, however, the maximal lifespan of male mutants was significantly increased when compared with that of male WT mice.
- % change in avg or median lifespan
- Mean lifespan is 11% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Overexpression
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Caenorhabditis elegans
- dop-4
- Danio rerio
- adra1bb
- Danio rerio
- adra1ba
- Drosophila melanogaster
- Dop1R2
- Homo sapiens
- ADRA1B
- Rattus norvegicus
- Adra1b
- Mouse Genome Informatics
- Search
- Ensembl
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- Entrez Gene
- View on Entrez Gene database (11548)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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GenAge entry for Adra1b (Mus musculus)