- Symbol
- NAT4
- Name
- Nat4p
- Organism
- Saccharomyces cerevisiae (AnAge)
- Observations
- Under normal conditions downregulation of NAT4 in yeast increased mean replicative lifespan by 21%. When yeast cells lacking NAT4 were subjected to calorie restriction (0.1% glucose versus 2% glucose) no further lifespan extension was displayed, lifespan was comparable to wild type cells under calorie restriction and yeast cells lacking NAT4 under normal conditions.
- % change in avg or median lifespan
- Mean replicative lifespan is 21% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenDR gene manipulations
- This gene is present as NAT4
- Schizosaccharomyces pombe
- SPCC825.04c
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (855091)
- Homologues
- Search HomoloGene
- UniProt
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GenAge entry for NAT4 (Saccharomyces cerevisiae)