- Symbol
- Eef1e1
- Aliases
- 1110003A02Rik
- Name
- Eukaryotic translation elongation factor 1 epsilon 1
- Organism
- Mus musculus (AnAge)
- Observations
- Mice that are homozygous null for AIMP3 showed early embryonic death; heterozygous mice are born alive but show highly increased susceptibility to various cancers.
Transgenic mice that express AIMP3 constitutively at higher level than WT controls exhibited a significantly shorter mean lifespan and a phenotype characteristic to mouse progeroid models (mice stopped gaining weight much earlier than their WT littermates, displayed alopecia, wrinkled skin with reduced adipocytes, lordokyphosis, reduced bone mineral deposits in female, and reduced bone thickness).
- % change in avg or median lifespan
- Median lifespan is 50% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Overexpression
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Danio rerio
- eef1e1
- Drosophila melanogaster
- CG30185
- Homo sapiens
- EEF1E1-BLOC1S5
- Rattus norvegicus
- Eef1e1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (66143)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Eef1e1 (Mus musculus)