Caenorhabditis elegansGenAge entry for bec-1 (Caenorhabditis elegans)

Gene information (ID: 44)

Symbol
bec-1
Name
BEClin (human autophagy) homolog
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Involved in autophagy

Potential relevance to longevity and/or ageing

Observations
Required for normal dauer morphogenesis and lifespan extension. RNA interference results in a shortened lifespan.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Shortened mean lifespan in eat-2 mutant background (24%) but not in wild-type.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      RNAi resulted in a 10-40% reduction in mean lifespan.
      % change in avg or median lifespan
      Average lifespan is 10-40% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        16% lifespan reduction (compared to wild type) and 25% lifespan reduction (in a daf-2 mutant) for RNAi from beginning of life. For post developmental RNAi maximum lifespan was extended by 10-15% both in wild-type and daf2 mutants.
        % change in avg or median lifespan
        Lifespan is up to 16% higher.
        Lifespan Effect
        Decrease
        Genetic Manipulation
        RNA interference
        Longevity Category
        Pro-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Saccharomyces cerevisiae is present as VPS30
          GenDR gene manipulations
          • This gene is present as bec-1
          • A homolog of this gene for Saccharomyces cerevisiae is present as VPS30
          CellAge
          • A homolog of this gene for Homo sapiens is present as BECN1

          Homologs in other organisms

          Danio rerio
          becn1
          Drosophila melanogaster
          Atg6
          Homo sapiens
          BECN2
          Homo sapiens
          BECN1
          Mus musculus
          Gm38100
          Mus musculus
          Becn1
          Rattus norvegicus
          Becn2
          Rattus norvegicus
          Becn1
          Saccharomyces cerevisiae
          VPS30
          Schizosaccharomyces pombe
          atg6

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (177345)
          Homologues
          Search HomoloGene
          UniProt
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          Internet
          Search Google or Search Google Scholar