Mus musculusGenAge entry for SOD3 (Mus musculus)

Gene information (ID: 2163)

Symbol
SOD3
Name
superoxide dismutase 3
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mice overexpressing a mutant variant of human SOD3 (R213G) had a shortened lifespan (11 months). Mice expressing the SOD3 transgene (SOD3-Tg) displayed features of accelerated ageing such as hair greying and abnormal gait. The mice also had systemic inflammation and organ degeneration.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SOD3

    Homologs in other organisms

    Homo sapiens
    SOD3
    Homo sapiens
    SOD3
    Homo sapiens
    SOD3
    Homo sapiens
    SOD3
    Homo sapiens
    SOD3

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (6649)
    Homologues
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    UniProt
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    Internet
    Search Google or Search Google Scholar