GenAge entry for Topors (Mus musculus)
Gene information (ID: 828)
- Symbol
- Topors
- Aliases
- LUN; TP53BPL; AW105885; p53BP3/LUN
- Name
- Topoisomerase I binding, arginine/serine-rich
- Organism
- Mus musculus (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Mice exhibited a significant reduction in mean and maximal lifespan for homozygote KO, slight reduction in mean and maximal lifespan for heterozygote KO compared to WT. Several mice showed some signs of premature aging, including kyphosis, and a high incidence of cancer (multiple forms of tumors).
- % change in max lifespan
- Maximum lifespan is 42% lower.
- % change in avg or median lifespan
- Median lifespan is 42% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
- Danio rerio
- TOPORS (1 of many)
- Danio rerio
- toporsa
- Drosophila melanogaster
- Topors
- Homo sapiens
- TOPORS
- Rattus norvegicus
- Topors
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (106021)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar