Drosophila melanogasterGenAge entry for Spargel (Drosophila melanogaster)

Gene information (ID: 1740)

Symbol
Spargel
Aliases
CG; 9809; cg9809; CG9809; Dmel\CG9809; dPGC; dPGC-1; PGC-
Name
Spargel
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Tissue-specific overexpression of dPGC-1 in stem and progenitor cells within the digestive tract of female flies extends lifespan. Flies display a delay in the onset of aging-related changes in the intestine, leading to improved tissue homeostasis in old flies.
% change in max lifespan
Maximum female lifespan is up to 37% higher.
% change in avg or median lifespan
Median female lifespan is up to 33% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression in stem and progenitor cells
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PPARGC1A
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PPARGC1A

    Homologs in other organisms

    Danio rerio
    ppargc1a
    Danio rerio
    ppargc1b
    Danio rerio
    si:dkey-93h22.8
    Danio rerio
    pprc1
    Homo sapiens
    PPRC1
    Homo sapiens
    PPARGC1A
    Homo sapiens
    PPARGC1B
    Mus musculus
    Pprc1
    Mus musculus
    Ppargc1b
    Mus musculus
    Ppargc1a
    Rattus norvegicus
    Pprc1
    Rattus norvegicus
    Ppargc1b
    Rattus norvegicus
    Ppargc1a

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (40562)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar