- Symbol
- Siglece
- Name
- sialic acid binding Ig-like lectin E
- Organism
- Mus musculus (AnAge)
- Observations
- Siglece-/- mice exhibited reduced survival and showed accelerated ageing as a result of imbalanced ROS metabolism and impaired detoxication of reactive molecules, which lead to increased oxidative stress. Overall survival of Siglece-/- males was 48% compared to 70% for the wildtype. Median survival of Siglece-/- decreased by 17%.
- % change in avg or median lifespan
- Median lifespan is 17% lower in females.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Danio rerio
- si:dkey-24p1.7
- Homo sapiens
- SIGLEC12
- Homo sapiens
- SIGLEC8
- Homo sapiens
- SIGLEC9
- Homo sapiens
- SIGLEC7
- Rattus norvegicus
- Siglec8
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (83382)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Siglece (Mus musculus)