- Symbol
- Pappa
- Aliases
- PAG1; PAPP-A; IGFBP-4ase; 8430414N03Rik
- Name
- Pregnancy-associated plasma protein A
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Could be involved in local cell proliferative processes
- Observations
- Genetic deletion of PAPPA extended mean and maximum lifespan by 30-40% and reduced cancer incidence with no reduction in food intake or secondary endocrine abnormalities.
- % change in max lifespan
- Maximum lifespan is 30-40% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Knockout mice had an approximately 30% increase in lifespan.
- % change in avg or median lifespan
- Average lifespan is 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockout
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PAPPA
- Danio rerio
- pappab
- Danio rerio
- pappaa
- Homo sapiens
- PAPPA
- Rattus norvegicus
- Pappa
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (18491)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Pappa (Mus musculus)