Caenorhabditis elegansGenAge entry for des-2 (Caenorhabditis elegans)

Gene information (ID: 175)

Symbol
des-2
Name
DEgeneration Suppressor
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Alpha subunit of nicotinic acetylcholine receptor (nAChR)

Potential relevance to longevity and/or ageing

Observations
Mutations in both des(bs29) and des(bs30) increase lifespan by approximately 60%.
% change in avg or median lifespan
Lifespan is approximately 60% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    si:ch211-256e16.6
    Danio rerio
    si:ch211-256e16.4
    Danio rerio
    si:ch211-256e16.10
    Danio rerio
    si:ch211-256e16.7
    Danio rerio
    si:ch211-256e16.8
    Danio rerio
    htr3a
    Danio rerio
    htr3b
    Danio rerio
    si:dkey-49c17.4
    Danio rerio
    FO818743.1
    Danio rerio
    HTR3C
    Danio rerio
    CABZ01038483.1
    Drosophila melanogaster
    nAChRbeta3
    Homo sapiens
    HTR3D
    Homo sapiens
    HTR3A
    Homo sapiens
    ZACN
    Homo sapiens
    HTR3C
    Homo sapiens
    HTR3B
    Homo sapiens
    HTR3E
    Mus musculus
    Htr3b
    Mus musculus
    Htr3a
    Rattus norvegicus
    Htr3a
    Rattus norvegicus
    Htr3b

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (179574)
    Homologues
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    UniProt
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    Internet
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