Caenorhabditis elegansGenAge entry for sod-2 (Caenorhabditis elegans)

Gene information (ID: 985)

Symbol
sod-2
Name
Superoxide dismutase (24.5 kD) (sod-2)
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Treatment of wild-type worms increased their mean LS by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their LS (a 67 percent increase).
% change in avg or median lifespan
Average lifespan is 44% higher.
Lifespan Effect
Increase
Genetic Manipulation
Pharmacological overexpression (Superoxide dismutase/catalase mimetics)
Longevity Category
Pro-Longevity
Primary reference
    Observations
    sod-2 mutants are long-lived (maximum lifespan increased by 30%) despite a significant increase in oxidatively damaged proteins. The lifespan of sod1, sod3, sod4 and sod5 mutants was not affected. Examination of worm lifespan revealed that sod-1; sod-3; sod-5 mutant worms live as long as wild-type worms while both sod-2; sod-3; sod-5 and sod-1; sod-2; sod- 4 mutant worms live significantly longer than wild-type (maximum lifespan increased by 30%).
    % change in max lifespan
    Maximum lifespan is 30% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutations
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
      • A homolog of this gene for Drosophila melanogaster is present as Sod2
      • A homolog of this gene for Mus musculus is present as Sod2
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as SOD2
      GenDR gene manipulations
      • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as SOD2

      Homologs in other organisms

      Danio rerio
      sod2
      Drosophila melanogaster
      Sod2
      Homo sapiens
      SOD2
      Homo sapiens
      SOD2
      Mus musculus
      Sod2
      Rattus norvegicus
      Sod2
      Saccharomyces cerevisiae
      SOD2

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (172632)
      Homologues
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      UniProt
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      Internet
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