- Symbol
- cul-1
- Name
- CULlin
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Scaffolding protein
- Observations
- RNAi decreased lifespan of daf-2 mutant, but not of WT or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signalling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Saccharomyces cerevisiae
- CDC53
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (176466)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for cul-1 (Caenorhabditis elegans)