The ceh-23 gene and its possible relation to ageing in roundworms

Gene information (ID: 1819)

Symbol: ceh-23
Name: Protein CEH-23
Organism: Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations

Worms transformed with 10 ng/ul of ceh-23 (red curve) rwEx16[ceh-23+mec-7::rfp] showed an increased lifespan (p<0.001, log-rank test) when compared to rwEx18[mec-7::rfp] control worms (black curve). By contrast, worms transformed with 1 ng/ul of ceh-23 (green curve) rwEx17[ceh-23+mec-7::rfp] showed only marginal lifespan increased (p = 0.036, log rank test) when compared to rwEx18[Pmec-7::rfp] control worms (black curve).

% change in max lifespan

Maximum lifespan is 30% higher.

% change in avg or median lifespan

Average lifespan is 25% higher.

Lifespan Effect

Increase

Genetic Manipulation

Overexpression

Longevity Category

Pro-Longevity

Primary reference

Observations

Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.

% change in avg or median lifespan

Average lifespan is 12% higher.