Caenorhabditis elegansGenAge entry for hlh-30 (Caenorhabditis elegans)

Gene information (ID: 2145)

Symbol
hlh-30
Name
Helix Loop Helix
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Worms overexpressing hlh-30 demonstrated a 15-20% increase in mean lifespan when compared to the wild type. This lifespan extension was linked to induction of autophagy.
% change in avg or median lifespan
Mean lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    tfe3a
    Danio rerio
    tfec
    Danio rerio
    tfeb
    Danio rerio
    tfe3b
    Danio rerio
    mitfb
    Danio rerio
    mitfa
    Drosophila melanogaster
    Mitf
    Homo sapiens
    TFE3
    Homo sapiens
    MITF
    Homo sapiens
    TFEC
    Homo sapiens
    TFEB
    Mus musculus
    Tfe3
    Mus musculus
    Mitf
    Mus musculus
    Tfeb
    Mus musculus
    Tfec
    Rattus norvegicus
    Mitf
    Rattus norvegicus
    Tfe3
    Rattus norvegicus
    Tfec
    Rattus norvegicus
    Tfeb

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (177157)
    Homologues
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    UniProt
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    Internet
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