- Symbol
- NPT1
- Name
- Nicotinatephosphoribosyltranfserase
- Organism
- Saccharomyces cerevisiae (AnAge)
- Known functions and activities
- Critical for the NAD+ salvage pathway
- Observations
- Increased dosage increases sir2-dependent silencing and extends yeast replicative lifespan by up to 60%.
- % change in avg or median lifespan
- Replicative lifespan is up to 60% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Increased dosage
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Chronological lifespan decreased
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Replicative lifespan decreased by 50%
- % change in avg or median lifespan
- Replicative lifespan is 50% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Necessary for fitness
- Primary reference
-
- GenDR gene manipulations
- This gene is present as NPT1
- Caenorhabditis elegans
- Y54G2A.17
- Danio rerio
- naprt1
- Drosophila melanogaster
- CG3714
- Schizosaccharomyces pombe
- SPAC1486.06
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (854384)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for NPT1 (Saccharomyces cerevisiae)