- Symbol
- HSP104
- Name
- chaperone ATPase HSP104
- Organism
- Saccharomyces cerevisiae (AnAge)
- Known functions and activities
- Heat shock protein
- Observations
- A 40% reduction in replicative lifespan was observed in knockouts. Overexpression had no effect on replicative lifespan but suppressed the reduced lifespan of Sir2-deficient cells.
- % change in avg or median lifespan
- Replicative lifespan is 40% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Necessary for fitness
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Schizosaccharomyces pombe is present as SPBC16D10.08c
- GenDR gene manipulations
- This gene is present as HSP104
- Danio rerio
- FO904873.1
- Danio rerio
- clpb
- Homo sapiens
- CLPB
- Mus musculus
- Clpb
- Rattus norvegicus
- Clpb
- Schizosaccharomyces pombe
- hsp104
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (850633)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for HSP104 (Saccharomyces cerevisiae)