- Symbol
- apl-1
- Name
- Beta-amyloid-like protein
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Apl-1 expression was induced in adult worms via heat shock. A single induction in day one adults mildly increased lifespan (5%) whereas regular apl-1 expression robustly increased lifespan (12-30%). Tissue specific expression had differing effects, neuron specific expression resulted in a decrease in lifespan whereas hypodermis specific expression resulted in lifespan extension.
- % change in avg or median lifespan
- Mean lifespan is 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as APLP1
- Danio rerio
- aplp1
- Drosophila melanogaster
- Appl
- Homo sapiens
- APLP1
- Mus musculus
- Aplp1
- Rattus norvegicus
- Aplp1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (180783)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for apl-1 (Caenorhabditis elegans)