Caenorhabditis elegansGenAge entry for ife-2 (Caenorhabditis elegans)

Gene information (ID: 360)

Symbol
ife-2
Name
Initiation Factor 4E (eIF4E) family
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
A scaffold protein for translation initiation factors

Potential relevance to longevity and/or ageing

Observations
Loss-of-function mutation increased maximum lifespan by about 20%. It did not extend the lifespan of daf-16(RNAi) animals. TOR RNA interference further extended lifespan.
% change in max lifespan
Maximum lifespan is about 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Loss of a specific eIF4E isoform (IFE-2) that functions in somatic tissues reduces global protein synthesis, protects from oxidative stress and extends maximum lifespan by 30% in C. elegans. Lifespan extension is independent of the forkhead transcription factor DAF-16, which mediates the effects of the insulin-like signalling pathway on ageing. Furthermore, IFE-2 deficiency further extends the lifespan of long-lived age (30%) and daf (15% maximum lifespan) nematode mutants. Knockdown of ife-2 extends the lifespan (50% maximum lifespan) of glp-4(bn2) mutant animals lacking a germ line. Similarly, lack of IFE-2 enhances the long-lived phenotype of clk (30% maximum lifespan) and dietary-restricted eat mutant animals (30% maximum lifespan). Knockdown of target of rapamycin (TOR), a phosphatidylinositol kinase that controls protein synthesis in response to nutrient cues, further increases the longevity of ife-2 mutants (10-15% maximum lifespan). Depletion of other eIF4E isoforms had no effect on longevity.
    % change in max lifespan
    Maximum lifespan is 30% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      RNAi resulted in a 10% maximum lifespan extension compared to wild-type.
      % change in max lifespan
      Maximum lifespan is 10% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference

        In other databases

        LongevityMap
        • A homolog of this gene for Homo sapiens is present as EIF4E
        CellAge
        • A homolog of this gene for Homo sapiens is present as EIF4E

        Homologs in other organisms

        Danio rerio
        eif4e1b
        Danio rerio
        eif4ea
        Danio rerio
        eif4eb
        Danio rerio
        eif4e1c
        Drosophila melanogaster
        eIF4E-6
        Drosophila melanogaster
        eIF-4E
        Drosophila melanogaster
        eIF4E-3
        Drosophila melanogaster
        eIF4E-7
        Drosophila melanogaster
        eIF4E-5
        Drosophila melanogaster
        eIF4E-4
        Homo sapiens
        EIF4E1B
        Homo sapiens
        EIF4E
        Mus musculus
        Eif4e1b
        Mus musculus
        Eif4e
        Rattus norvegicus
        Eif4e
        Saccharomyces cerevisiae
        CDC33

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (180393)
        Homologues
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        UniProt
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        Internet
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