Caenorhabditis elegansGenAge entry for daf-7 (Caenorhabditis elegans)

Gene information (ID: 169)

Symbol
daf-7
Name
abnormal DAuer Formation
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Encodes a member of the TGF-beta superfamily that affects dauer larvae

Potential relevance to longevity and/or ageing

Observations
Mutations cause up to 50% mean and maximum life-extension. This effect is dependent upon daf-3 and on daf-16 but independent of daf-2. RNA interference increased mean lifespan by 30% and maximum lifespan by 10%.
% change in max lifespan
Maximum lifespan is up to 50% higher.
% change in avg or median lifespan
Average lifespan is up to 50% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    No homologs found

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (175237)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar