Caenorhabditis elegansGenAge entry for CELE_W09C5.8 (Caenorhabditis elegans)

Gene information (ID: 729)

Symbol
CELE_W09C5.8
Name
Protein W09C5.8
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Cytochrome c oxidase, subunit IV/COX5b

Potential relevance to longevity and/or ageing

Observations
RNA interference extends lifespan about 60%.
% change in avg or median lifespan
Lifespan is about 60% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNAi resulted in lifespan extension.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      60-100% extended mean lifespan when inactivated post developmentally, in different backgrounds.
      % change in avg or median lifespan
      Average lifespan is 60-100% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        RNAi led to a 40% mean lifespan extension.
        % change in avg or median lifespan
        Average lifespan is 40% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference

          Homologs in other organisms

          Danio rerio
          cox4i1
          Danio rerio
          cox4i2
          Danio rerio
          cox4i1l
          Drosophila melanogaster
          CG10396
          Drosophila melanogaster
          CoIV
          Homo sapiens
          COX4I2
          Homo sapiens
          COX4I1
          Mus musculus
          Cox4i2
          Mus musculus
          Cox4i1
          Rattus norvegicus
          Cox4i1
          Rattus norvegicus
          Cox4i2

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (173237)
          Homologues
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          UniProt
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          Internet
          Search Google or Search Google Scholar