- Symbol
- ctbp-1
- Name
- C-terminal-binding protein 1
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- The C. elegans ctbp-1 mutants (ok498), lacking the NAD(H)-binding domain and most of the dehydrogenase catalytic domain, display an increase in mean adult life span (~20%) and maximal life span (~10–20%). Depletion of ctbp-1 by RNA interference results in similar lifespan extension effects, while reintroduction of the ctbp-1 gene rescues the lifespan phenotype. Most probably, CTBP-1 modulates aging through the insulin/IGF-1 signaling pathway and its effect is dependent on existence of DAF-16.
- % change in max lifespan
- Maximum lifespan is up to 20% higher.
- % change in avg or median lifespan
- Mean lifespan is about 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Knockdown mutations (eg613 and tm5512) in CTBP-1 result in a lifespan expansion of up to 5-10% and 5-25%, respectively. Constrastly to previous observations however (Chen et al., 2009), no change in lifespan was observed for the ok498 mutation (which might be due to using independently outcrossed strains derived from RB733 ctbp-1 ok498).
- % change in avg or median lifespan
- Median lifespan is up to 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Danio rerio
- ctbp2a
- Danio rerio
- 678649
- Danio rerio
- ctbp1
- Drosophila melanogaster
- CtBP
- Homo sapiens
- CTBP2
- Homo sapiens
- CTBP1
- Mus musculus
- Ctbp1
- Mus musculus
- Ctbp2
- Rattus norvegicus
- Ctbp1
- Rattus norvegicus
- Ctbp2
- Saccharomyces cerevisiae
- SER33
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (180853)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for ctbp-1 (Caenorhabditis elegans)