Mus musculusGenAge entry for Col1a1 (Mus musculus)

Gene information (ID: 2009)

Symbol
Col1a1
Name
collagen, type I, alpha 1
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mice with a mutation in the Col1a1 gene, that yields collagenase-resistant type I collagen, display a shortened lifespan, when compared with wild-type littermates, and develop features of premature aging (including kyphosis, weight loss, decreased bone mineral density, and hypertension).
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge microarray genes
    • A homolog of this gene for Homo sapiens is present as COL1A1

    Homologs in other organisms

    Danio rerio
    col1a1a
    Danio rerio
    col1a1b
    Homo sapiens
    COL1A1
    Rattus norvegicus
    Col1a1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (12842)
    Homologues
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    UniProt
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    Internet
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