Caenorhabditis elegansGenAge entry for bcat-1 (Caenorhabditis elegans)

Gene information (ID: 2112)

Symbol
bcat-1
Name
Branched-chain-amino-acid aminotransferase, cytosolic
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Downregulation of bcat-1 in worms increased mean lifespan by 25% and maximum lifespan by 19%. In addition to extending lifespan bcat-1 downregulation also increased health span.
% change in max lifespan
Maximum lifespan is 19% higher.
% change in avg or median lifespan
Mean lifespan is 25% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    bcat2
    Danio rerio
    bcat1
    Drosophila melanogaster
    CG1673
    Homo sapiens
    BCAT1
    Homo sapiens
    BCAT2
    Mus musculus
    Bcat2
    Mus musculus
    Bcat1
    Rattus norvegicus
    Bcat2
    Rattus norvegicus
    Bcat1
    Saccharomyces cerevisiae
    BAT1
    Saccharomyces cerevisiae
    BAT2

    External links

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    Entrez Gene
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    Internet
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