GenAge entry for nnt-1 (Caenorhabditis elegans)
Gene information (ID: 465)
- Symbol
- nnt-1
- Name
- Nicotinamide Nucleotide Transhydrogenase
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Nicotinamide nucleotide transhydrogenase
Potential relevance to longevity and/or ageing
- Observations
- nnt-1 appears to inhibit the growth of gld-1 tumours. RNA interference reduced mean lifespan up to 18% in wild type animals, 20% in daf-2 mutants and 16% in daf-2/gld-1 mutants.
- % change in avg or median lifespan
- Average lifespan is up to 18% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
- Danio rerio
- nnt
- Danio rerio
- si:ch1073-221c23.2
- Danio rerio
- nnt2
- Homo sapiens
- NNT
- Mus musculus
- Nnt
- Rattus norvegicus
- Nnt
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (180884)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar