- Symbol
- bmk-1
- Name
- Kinesin-like protein
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Overexpression of bmk-1 in worms resulted in a 25% increase in lifespan and enhanced heat shock resistance. Downregulation of bmk-1 using RNAi resulted in a 32% decrease in lifespan. Hsp-16 was upregulated in response to bmk-1 overexpression, suggesting bmk-1 may protect cells from stress and inhibit apoptosis.
- % change in avg or median lifespan
- Median lifespan is 25% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge
- A homolog of this gene for Homo sapiens is present as KIF11
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as KIF11
- Danio rerio
- kif11
- Drosophila melanogaster
- Klp61F
- Homo sapiens
- KIF11
- Mus musculus
- Kif11
- Rattus norvegicus
- Kif11
- Saccharomyces cerevisiae
- CIN8
- Saccharomyces cerevisiae
- KIP1
- Schizosaccharomyces pombe
- cut7
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (179948)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for bmk-1 (Caenorhabditis elegans)