Caenorhabditis elegansGenAge entry for atp-2 (Caenorhabditis elegans)

Gene information (ID: 25)

Symbol
atp-2
Name
ATP synthase F1 subunit gamma
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase

Potential relevance to longevity and/or ageing

Observations
RNA interference of atp-2 results in an increased lifespan.
% change in avg or median lifespan
Mean lifespan is 14.8% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    atp-2 mutation significantly lengthen (by 20%) the lifespan of the arrested animals.
    % change in avg or median lifespan
    Average lifespan is 20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      RNA interference results in extended lifespan.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Post developmental RNAi resulted in a 43% increase in mean lifespan.
        % change in avg or median lifespan
        Average lifespan is 43% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Saccharomyces cerevisiae is present as ATP2
          GenAge microarray genes
          • A homolog of this gene for Homo sapiens is present as ATP5F1B

          Homologs in other organisms

          Danio rerio
          atp5b
          Drosophila melanogaster
          ATPsyn-beta
          Homo sapiens
          ATP5B
          Mus musculus
          Atp5b
          Rattus norvegicus
          Atp5b
          Saccharomyces cerevisiae
          ATP2
          Schizosaccharomyces pombe
          atp2

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (175716)
          Homologues
          Search HomoloGene
          UniProt
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          Internet
          Search Google or Search Google Scholar