Caenorhabditis elegansGenAge entry for kat-1 (Caenorhabditis elegans)

Gene information (ID: 950)

Symbol
kat-1
Name
3-Ketoacyl-coA Thiolase
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Increased accumulation of the lipofuscin-like fluorescent aging pigment, shortened median lifespan (30% reduction compared to WT). Early behavioral decline, and other abnormalities characteristic of premature aging were observed.
% change in avg or median lifespan
Median lifespan is 53% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutations
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    acat1
    Drosophila melanogaster
    CG10932
    Homo sapiens
    ACAT1
    Mus musculus
    Acat1
    Rattus norvegicus
    Acat1
    Saccharomyces cerevisiae
    ERG10

    External links

    WormBase
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    Entrez Gene
    View on Entrez Gene database (174161)
    Homologues
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    UniProt
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    Internet
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