Caenorhabditis elegansGenAge entry for miro-1 (Caenorhabditis elegans)

Gene information (ID: 2095)

Symbol
miro-1
Name
Mitochondrial Rho GTPase 1
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Downregulation of miro-1 simultaneously in multiple tissues resulted in an increase in lifespan. In addition the amount of mitochondria in miro-1 mutants was approximately 50% of the wild type.
% change in avg or median lifespan
Median lifespan is 50% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    rhot1b
    Danio rerio
    rhot2
    Danio rerio
    rhot1a
    Drosophila melanogaster
    Miro
    Homo sapiens
    RHOT2
    Homo sapiens
    RHOT1
    Mus musculus
    Rhot2
    Mus musculus
    Rhot1
    Mus musculus
    Gm20683
    Rattus norvegicus
    Rhot1
    Rattus norvegicus
    Rhot2
    Saccharomyces cerevisiae
    GEM1

    External links

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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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