Saccharomyces cerevisiaeGenAge entry for MCA1 (Saccharomyces cerevisiae)

Gene information (ID: 1916)

Symbol
MCA1
Aliases
YCA1
Name
Ca(2+)-dependent cysteine protease MCA1
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Lack of Mca1 has little effect on replicative life span in wild type yeast cells, and an accelerated aging effect in cells also lacking Ydj1. Overexpression of Mca1 extends lifespan by 46-56% in a Ydj1 dependent manner.
% change in avg or median lifespan
Median lifespan is 46-56% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Schizosaccharomyces pombe
    pca1

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (854372)
    Homologues
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    UniProt
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    Internet
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