- Symbol
- Sirt7
- Name
- Sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)
- Organism
- Mus musculus (AnAge)
- Observations
- No obvious phenotype was observed in heterozygous mutant Sirt7 animals, whereas homozygous mutants showed various signs of aging-related changes and died prematurely. Mutant mice developed kyphosis and lost subcutaneous fat early in life, and showed a general decrease in stress-resistance mechanisms. Mice develop heart hypertrophy and inflammatory cardiomyopathy. Sirt7 mutant hearts are also characterized by extensive fibrosis, leading to an increase in collagen III accumulation.
- % change in max lifespan
- Maximum lifespan is 55% lower.
- % change in avg or median lifespan
- Average lifespan is 59% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutations
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SIRT7
- Danio rerio
- sirt7
- Drosophila melanogaster
- Sirt7
- Homo sapiens
- SIRT7
- Rattus norvegicus
- Sirt7
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (209011)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Sirt7 (Mus musculus)