Caenorhabditis elegansGenAge entry for glp-1 (Caenorhabditis elegans)

Gene information (ID: 308)

Symbol
glp-1
Name
abnormal Germ Line Proliferation
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Receptor for a germ-line proliferation signal

Potential relevance to longevity and/or ageing

Observations
Mutations result in defects in germ-line proliferation and extension of lifespan by about 30%.
% change in avg or median lifespan
Lifespan is about 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Post developmental RNAi resulted in a 33% mean lifespan extension.
    % change in avg or median lifespan
    Average lifespan is 33% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      dld
      Danio rerio
      dla
      Danio rerio
      dlc
      Danio rerio
      JAG2 (1 of many)
      Danio rerio
      dlb
      Danio rerio
      jag1a
      Danio rerio
      dll4
      Danio rerio
      jag1b
      Danio rerio
      jag2b
      Danio rerio
      CABZ01041002.1
      Homo sapiens
      DLL4
      Homo sapiens
      JAG2
      Homo sapiens
      DLL1
      Homo sapiens
      JAG1
      Mus musculus
      Dll1
      Mus musculus
      Jag2
      Mus musculus
      Jag1
      Mus musculus
      Dll4
      Rattus norvegicus
      Dll4
      Rattus norvegicus
      Dll1
      Rattus norvegicus
      Jag1
      Rattus norvegicus
      Jag2

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (176286)
      Homologues
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      UniProt
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      Internet
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