Caenorhabditis elegansGenAge entry for pha-4 (Caenorhabditis elegans)

Gene information (ID: 503)

Symbol
pha-4
Name
defective PHArynx development
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Pharynx development

Potential relevance to longevity and/or ageing

Observations
PHA-4 may play a role in the life-extending effects of dietary restriction. RNA interference decreased lifespan of wild-type worms, but not of daf-2 mutants or of animals with defective electron transport chains. Overexpression slightly increased longevity.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    RNAi of pha-4 in adult animals led to a slightly shortened mean lifespan (13%).
    % change in avg or median lifespan
    Average lifespan is 13% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Drosophila melanogaster is present as fkh
      GenDR gene manipulations
      • This gene is present as pha-4

      Homologs in other organisms

      Drosophila melanogaster
      fkh
      Homo sapiens
      FOXA3
      Homo sapiens
      FOXA1
      Mus musculus
      Foxa3
      Mus musculus
      Foxa1
      Rattus norvegicus
      Foxa3
      Rattus norvegicus
      Foxa1

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (180357)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar