Caenorhabditis elegansGenAge entry for par-5 (Caenorhabditis elegans)

Gene information (ID: 493)

Symbol
par-5
Name
abnormal embryonic PARtitioning of cytoplasm
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
RNA interference slightly shortens lifespan and suppresses life-extension by sir-2.1 overexpression but not by daf-2 mutants. Overexpression extends lifespan by 30%, but is suppressed by RNA interference of daf-16.
% change in avg or median lifespan
Lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Post developmental RNAi let to a 15% mean lifespan reduction in wild type though no significant changes in maximal lifespan.
    % change in avg or median lifespan
    Average lifespan is 15% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as BMH1
      • A homolog of this gene for Saccharomyces cerevisiae is present as BMH2
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as YWHAZ
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as YWHAG
      CellAge
      • A homolog of this gene for Homo sapiens is present as SFN

      Homologs in other organisms

      Danio rerio
      ywhaqa
      Danio rerio
      ywhabb
      Danio rerio
      ywhaz
      Danio rerio
      ywhaqb
      Danio rerio
      ywhabl
      Danio rerio
      ywhaba
      Danio rerio
      ywhag1
      Danio rerio
      ywhah
      Danio rerio
      ywhag2
      Drosophila melanogaster
      14-3-3zeta
      Homo sapiens
      SFN
      Homo sapiens
      YWHAB
      Homo sapiens
      YWHAH
      Homo sapiens
      YWHAQ
      Homo sapiens
      YWHAZ
      Homo sapiens
      YWHAG
      Mus musculus
      Sfn
      Mus musculus
      Ywhah
      Mus musculus
      Ywhag
      Mus musculus
      Ywhaq
      Mus musculus
      Ywhaz
      Mus musculus
      Ywhab
      Rattus norvegicus
      Ywhaz
      Rattus norvegicus
      Sfn
      Rattus norvegicus
      LOC298795
      Rattus norvegicus
      Ywhag
      Rattus norvegicus
      Ywhab
      Rattus norvegicus
      Ywhaq
      Rattus norvegicus
      Ywhah
      Saccharomyces cerevisiae
      BMH2
      Saccharomyces cerevisiae
      BMH1
      Schizosaccharomyces pombe
      rad25

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (178113)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar