- Symbol
- impt-1
- Name
- Protein IMPACT homolog
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Knockdown of impt-1 activated the integrated stress response, involved in helping cells adapt to conditions of nutrient shortage. RNAi treated worms lived 16% longer than the controls. Whole body reduction of impt-1 was required to achieve this effect.
- % change in avg or median lifespan
- Median lifespan is 16% higher
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as YIH1
- Danio rerio
- impact
- Homo sapiens
- IMPACT
- Mus musculus
- Impact
- Rattus norvegicus
- Impact
- Saccharomyces cerevisiae
- YIH1
- Schizosaccharomyces pombe
- yih1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (173001)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for impt-1 (Caenorhabditis elegans)