Caenorhabditis elegansGenAge entry for impt-1 (Caenorhabditis elegans)

Gene information (ID: 2087)

Symbol
impt-1
Name
Protein IMPACT homolog
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Knockdown of impt-1 activated the integrated stress response, involved in helping cells adapt to conditions of nutrient shortage. RNAi treated worms lived 16% longer than the controls. Whole body reduction of impt-1 was required to achieve this effect.
% change in avg or median lifespan
Median lifespan is 16% higher
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as YIH1

    Homologs in other organisms

    Danio rerio
    impact
    Homo sapiens
    IMPACT
    Mus musculus
    Impact
    Rattus norvegicus
    Impact
    Saccharomyces cerevisiae
    YIH1
    Schizosaccharomyces pombe
    yih1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (173001)
    Homologues
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    UniProt
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    Internet
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