Caenorhabditis elegansGenAge entry for dot-1.1 (Caenorhabditis elegans)

Gene information (ID: 2233)

Symbol
dot-1.1
Name
DOT1 histone methyltransferase
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Downregulation of dot-1.1 in post-reproductive rrf-3 worms (9 days) increased mean lifespan by 15%.
% change in avg or median lifespan
Mean lifespan is 15% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as DOT1

    Homologs in other organisms

    Danio rerio
    dot1l
    Drosophila melanogaster
    gpp
    Homo sapiens
    DOT1L
    Mus musculus
    Dot1l
    Rattus norvegicus
    Dot1l
    Saccharomyces cerevisiae
    DOT1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (171797)
    Homologues
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    UniProt
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    Internet
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