- Symbol
- Serpine1
- Name
- serine (or cysteine) peptidase inhibitor, clade E, member 1
- Organism
- Mus musculus (AnAge)
- Observations
- The KLOTHO-deficient mice exhibit an accelerated aging phenotype including reduced lifespan, arteriosclerosis, and emphysema. PAI-1 (SERPINE1) deficiency retards the development of senescence and protects organ structure and function while prolonging the lifespan of the mutant mice. Median lifespan of KLOTHO/PAI-1 deficient mice is 2.8-fold and 4.2-fold higher (for PAI-1+/- and PAI-1-/- respectively) than the lifespan of KLOTHO deficient mice. Similar lifespan prolongation was obtained pharmacologically with a PAI-1 antagonist. Both males and females appear to benefit from complete PAI-1 deficiency, whil pai-1+/- deficiency had a smaller effect on females than on males. Maximum lifespan is also increased. The lifespan extension was also accompanied by increased overall vigor and health, the mutant mice exhibiting near-normal weight gain over time and spontaneous physical activity.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion in the Klotho mutant background
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SERPINE1
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as SERPINE1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SERPINE1
- CellAge
- A homolog of this gene for Homo sapiens is present as SERPINE1
- Caenorhabditis elegans
- srp-3
- Caenorhabditis elegans
- srp-2
- Caenorhabditis elegans
- srp-1
- Caenorhabditis elegans
- srp-7
- Caenorhabditis elegans
- srp-6
- Caenorhabditis elegans
- srp-8
- Danio rerio
- serpine1
- Drosophila melanogaster
- Spn38F
- Drosophila melanogaster
- Spn28F
- Drosophila melanogaster
- Spn42Dd
- Drosophila melanogaster
- Spn42Da
- Drosophila melanogaster
- Spn28Db
- Drosophila melanogaster
- Spn55B
- Drosophila melanogaster
- Spn42Db
- Drosophila melanogaster
- Spn28Da
- Drosophila melanogaster
- Spn28B
- Drosophila melanogaster
- Spn42Dc
- Drosophila melanogaster
- Spn42De
- Drosophila melanogaster
- nec
- Drosophila melanogaster
- Spn43Aa
- Drosophila melanogaster
- Spn43Ab
- Drosophila melanogaster
- Spn47C
- Homo sapiens
- SERPINE1
- Rattus norvegicus
- Serpine1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (18787)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar