- Symbol
- hsp-6
- Name
- Heat shock 70kDa protein 9B (mortalin-2)
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Stress-induced chaperone
- Observations
- Overexpression in transgenic worms extended lifespan by 43% for mean and 45% for maximum lifespan.
- % change in max lifespan
- Maximum lifespan is 45% higher.
- % change in avg or median lifespan
- Average lifespan is 43% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Knockdown of HSP-6 by RNAi in young adult nematodes caused a reduction in the levels of ATP-2, HSP-60 and CLK-1, leading to abnormal mitochondrial morphology and lower ATP level. As a result, RNAi-treated worms had lower motility, defects in oogenesis, earlier accumulation of autofluorescent material and a shorter lifespan (15% reduction).
- % change in avg or median lifespan
- Lifespan is 15% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SSC1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as HSPA9
- CellAge
- A homolog of this gene for Homo sapiens is present as HSPA9
- Danio rerio
- hspa9
- Drosophila melanogaster
- Hsc70-5
- Homo sapiens
- HSPA9
- Mus musculus
- Hspa9
- Rattus norvegicus
- Hspa9
- Saccharomyces cerevisiae
- SSC1
- Schizosaccharomyces pombe
- ssp1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (178873)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for hsp-6 (Caenorhabditis elegans)