- Symbol
- alh-6
- Name
- ALdehyde deHydrogenase
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- RNA interference or mutations in ALH-6 results in a shortened lifespan by up to 40%. This effect is however diet-specific and can be observed when animals are raised on the standard laboratory E. coli OP50 diet or when fed BL21, but not when fed HT115 or HMS174 (with an intermediate effect on a HB101 diet). The observed progeroid phenotype does not seem to be due to general sickness or developmental defects, and other signs of premature ageing are observed (reproductive decline, smaller total brood, lipofuscin accumulation, pharyngeal muscle degeneration, decrease in pharyngeal pumping and movement).
- % change in avg or median lifespan
- Mean lifespan is approximately 40% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Transgenic overexpression of ALH-6 extends lifespan in worms fed a standard E. coli OP50 diet, but not when fed HT115. A diet-dependent effect can also be seen when ALH-6 is inpaired through mutations, suggesting that ALH-6 offers an adaptive response promoting survival on particular diets.
- % change in max lifespan
- Maximum lifespan is approximately 20% higher.
- % change in avg or median lifespan
- Mean lifespan is approximately 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenDR gene manipulations
- This gene is present as alh-6
- Danio rerio
- aldh4a1
- Drosophila melanogaster
- P5CDh1
- Drosophila melanogaster
- P5CDh2
- Homo sapiens
- ALDH4A1
- Mus musculus
- Aldh4a1
- Saccharomyces cerevisiae
- PUT2
- Schizosaccharomyces pombe
- SPBC24C6.04
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (173510)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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GenAge entry for alh-6 (Caenorhabditis elegans)