- Symbol
- Rbm38
- Aliases
- Seb4; Rnpc1; Seb4l
- Name
- RNA binding motif protein 38
- Organism
- Mus musculus (AnAge)
- Observations
- Rbm38-null mice exhibit signs of accelerated ageing and live shorter than wild-type. While during their first year of life, mutants are indistinguishable from wild type mice, by 18 month, most of the mutant mice exhibit weight loss (mostly due to smaller adipocytes), reduced ratio of gonadal fat vs. body weight, lordokyphosis (displaying a hunchback) and ulcerated skin lesions. They are also more prone to hematopoietic defects and spontaneous tumors. Median and maximum survival time for tumor-free mice was reduced compared to wild type mice by 22% and 11%, respectively.
- % change in max lifespan
- Maximum tumor-free survival is 11% lower.
- % change in avg or median lifespan
- Median tumor-free survival is 11% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Caenorhabditis elegans
- sup-12
- Danio rerio
- rbm38
- Homo sapiens
- RBM38
- Rattus norvegicus
- Rbm38
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (56190)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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GenAge entry for Rbm38 (Mus musculus)