Caenorhabditis elegansGenAge entry for clk-1 (Caenorhabditis elegans)

Gene information (ID: 130)

Symbol
clk-1
Name
Coenzyme Q7 homolog
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Ubiquinone (coenzyme Q, CoQ) biosynthesis

Potential relevance to longevity and/or ageing

Observations
Mutations slow down development and extend lifespan.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Primary reference
    Observations
    Overexpression of CLK-1 activity in wild-type worms can increase mitochondrial activity, accelerate behavioral rates during aging and shorten lifespan.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Overexpression
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      RNAi resulted in a lifespan extension by 40%.
      % change in avg or median lifespan
      Lifespan is 40% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Clk-1 mutants display lifespan extension compared to wild-type.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Mutation
        Longevity Category
        Anti-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Mus musculus is present as Coq7
          • A homolog of this gene for Saccharomyces cerevisiae is present as CAT5
          GenAge human genes
          • A homolog of this gene for Homo sapiens is present as COQ7
          GenDR gene manipulations
          • This gene is present as clk-1
          LongevityMap
          • A homolog of this gene for Homo sapiens is present as COQ7

          Homologs in other organisms

          Danio rerio
          coq7
          Drosophila melanogaster
          COQ7
          Homo sapiens
          COQ7
          Mus musculus
          Coq7
          Rattus norvegicus
          Coq7
          Saccharomyces cerevisiae
          CAT5
          Schizosaccharomyces pombe
          coq7

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (175729)
          Homologues
          Search HomoloGene
          UniProt
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          Internet
          Search Google or Search Google Scholar