Drosophila melanogasterGenAge entry for fkh (Drosophila melanogaster)

Gene information (ID: 2241)

Symbol
fkh
Name
fork head
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Moderate adult-specific upregulation of fkh in flies increased median survival up to 14%. However, strong fkh induction led to short-lived flies. Gut specific expression of fkh improves gut barrier function in aged flies and increases the expression of nutrient transporters.
% change in avg or median lifespan
Median lifespan is 14% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as pha-4
    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as pha-4

    Homologs in other organisms

    Caenorhabditis elegans
    pha-4
    Danio rerio
    foxa1
    Danio rerio
    foxa2
    Danio rerio
    foxa
    Danio rerio
    foxa3
    Homo sapiens
    FOXA2
    Homo sapiens
    FOXA3
    Homo sapiens
    FOXA1
    Mus musculus
    Foxa3
    Mus musculus
    Foxa1
    Mus musculus
    Foxa2
    Rattus norvegicus
    Foxa1
    Rattus norvegicus
    Foxa2
    Rattus norvegicus
    Foxa3

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (43383)
    Homologues
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    UniProt
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    Internet
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