Caenorhabditis elegansGenAge entry for pbs-5 (Caenorhabditis elegans)

Gene information (ID: 1980)

Symbol
pbs-5
Name
Proteasome subunit beta type
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Transgenic overexpression of pbs-5, which leads to increased proteasome content, assembly, and activity in worms, results in extension of animal lifespan (~25%). The lifespan extension was accompanied by lower level of lipofuscin, slightly slower developmental timing and defecation rhythms, and increased capacity to enter the stress-resistant dauer larvae form, but no severe physiologic alterations were observed between mutants and wild type controls. Subsequent knock-down of pbs-5 by RNAi abolished the extended lifespan of pbs-5 overexpressing animals.
% change in avg or median lifespan
Mean lifespan is approximately 25% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Psmb8
    CellAge
    • A homolog of this gene for Homo sapiens is present as PSMB5

    Homologs in other organisms

    Danio rerio
    psmb5
    Danio rerio
    psmb11b
    Danio rerio
    psmb8a
    Drosophila melanogaster
    Prosbeta5R2
    Drosophila melanogaster
    Prosbeta5
    Drosophila melanogaster
    Prosbeta5R1
    Homo sapiens
    PSMB5
    Homo sapiens
    PSMB8
    Homo sapiens
    PSMB11
    Mus musculus
    Psmb11
    Mus musculus
    Psmb5
    Mus musculus
    Psmb8
    Rattus norvegicus
    Psmb8
    Rattus norvegicus
    Psmb5
    Rattus norvegicus
    Psmb11
    Saccharomyces cerevisiae
    PRE2
    Schizosaccharomyces pombe
    pts1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (173334)
    Homologues
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    UniProt
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    Internet
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