- Symbol
- gpa-11
- Name
- G Protein, Alpha subunit
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- G Protein, Alpha subunit
- Observations
- Increase in mean lifespan by up to 25% when gpa-11 is overexpressed and a slight (5%) but non-significant decrease in lifespan in knockouts. Lifespan extension was dependent on daf-16. Loss-of-function of odr-3 and extra copies of gpa-11 synergistically extended lifespan. Extra copies of gpa-11 shortened the lifespan of daf-2 mutants. Loss-of-function of gpa-11 in daf-2 mutants further extended lifespan.
- % change in avg or median lifespan
- Average lifespan is up to 25% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Saccharomyces cerevisiae
- GPA1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (173759)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for gpa-11 (Caenorhabditis elegans)