Caenorhabditis elegansGenAge entry for dagl-2 (Caenorhabditis elegans)

Gene information (ID: 1930)

Symbol
dagl-2
Name
DiAcylGlycerol Lipase homolog
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of dagl-2 (an ortholog of the fly inaE) extends mean lifespan by up to 13%. Conversely, RNA interference of dagl-2 results in a lifespan decrease of up to 14%, while loss-of-function mutantions result in a shorten lifespan by up to 20%.
% change in avg or median lifespan
Mean lifespan is up to 13% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    CellAge gene expression
    • A homolog of this gene for Homo sapiens is present as DAGLB

    Homologs in other organisms

    Danio rerio
    daglb
    Homo sapiens
    DAGLB
    Mus musculus
    Daglb
    Rattus norvegicus
    Daglb

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (3565075)
    Homologues
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    UniProt
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    Internet
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