- Symbol
- isp-1
- Name
- Iron-Sulfur Protein
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Iron sulfur protein of mitochondrial complex III
- Observations
- A missense mutation leads to low oxygen consumption, decreased sensitivity to reactive oxygen species, and increased mean (60%) and maximum (100%) lifespan.
- % change in max lifespan
- Maximum lifespan is 100% higher.
- % change in avg or median lifespan
- Average lifespan is 60% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Primary reference
-
- Observations
- Treating the respiratory mutant isp-1(qm150) with rps-15 or S6K/rsks-1 RNAi further extended its lifespan by 25-30%.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RIP1
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as UQCRFS1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as UQCRFS1
- Danio rerio
- uqcrfs1
- Drosophila melanogaster
- RFeSP
- Homo sapiens
- UQCRFS1
- Mus musculus
- Uqcrfs1
- Rattus norvegicus
- Uqcrfs1
- Saccharomyces cerevisiae
- RIP1
- Schizosaccharomyces pombe
- rip1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (177609)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for isp-1 (Caenorhabditis elegans)